Gene Symbol: pth1b
Description: parathyroid hormone 1b
Alias: pth2, parathyroid hormone, parathyroid hormone 2, parathyroid hormone ligand type-2
Species: zebrafish

Top Publications

  1. Okabe M, Graham A. The origin of the parathyroid gland. Proc Natl Acad Sci U S A. 2004;101:17716-9 pubmed publisher
    It has long been held that the parathyroid glands and parathyroid hormone evolved with the emergence of the tetrapods, reflecting a need for new controls on calcium homeostasis in terrestrial, rather than aquatic, environments...
  2. Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, et al. A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Hum Genet. 2017;136:835-845 pubmed publisher
    ..Altogether, our data suggest that FHL1 is a novel regulator of calcium homeostasis and implicate it as the causative gene for X-linked recessive hypoparathyroidism. ..
  3. Suarez Bregua P, Cal L, Canestro C, Rotllant J. PTH Reloaded: A New Evolutionary Perspective. Front Physiol. 2017;8:776 pubmed publisher
    The parathyroid hormone (PTH) family is a group of structurally-related secreted peptides involved in bone mineral homeostasis and multitude of developmental processes in vertebrates...
  4. Gensure R, Ponugoti B, Gunes Y, Papasani M, Lanske B, Bastepe M, et al. Identification and characterization of two parathyroid hormone-like molecules in zebrafish. Endocrinology. 2004;145:1634-9 pubmed
    ..The availability of multiple forms of fish PTH and their receptors provide additional tools for PTH ligand/receptor structure-function studies. ..
  5. Papasani M, Gensure R, Yan Y, Gunes Y, Postlethwait J, Ponugoti B, et al. Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39. Endocrinology. 2004;145:5294-304 pubmed
    ..Because the mammalian PTH2R was also most abundantly expressed in these tissues, the TIP39-PTH2R system may serve conserved physiological roles in mammals and fishes. ..
  6. Hogan B, Danks J, Layton J, Hall N, Heath J, Lieschke G. Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis. Endocrinology. 2005;146:547-51 pubmed
    ..We report the expression patterns of duplicate zebrafish pth genes during embryogenesis. Both zebrafish pth1 and pth2 transcripts are expressed along the lateral line before the migration of the lateral line primordium and later in ..
  7. Catchen J, Conery J, Postlethwait J. Automated identification of conserved synteny after whole-genome duplication. Genome Res. 2009;19:1497-505 pubmed publisher
    ..To demonstrate the utility of the system, we present a case study of gene family evolution, investigating the ARNTL gene family in the genomes of Ciona intestinalis, amphioxus, zebrafish, and human. ..
  8. Renn J, Winkler C, Schartl M, Fischer R, Goerlich R. Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma. 2006;229:209-14 pubmed
    ..Furthermore, it will help to identify novel genes and regulatory pathways of bone homeostasis and skeletal disorders also in higher vertebrates, including disorders caused by altered gravity. ..
  9. Bhattacharya P, Yan Y, Postlethwait J, Rubin D. Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. J Endocrinol. 2011;211:187-200 pubmed publisher
    In mammals, parathyroid hormone (PTH), secreted by parathyroid glands, increases calcium levels in the blood from reservoirs in bone...

More Information


  1. Yan Y, Bhattacharya P, He X, Ponugoti B, Marquardt B, Layman J, et al. Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. J Endocrinol. 2012;214:421-35 pubmed publisher
    In mammals, parathyroid hormone-related peptide (PTHrP, alias PTH-like hormone (Pthlh)) acts as a paracrine hormone that regulates the patterning of cartilage, bone, teeth, pancreas, and thymus...
  2. Lin C, Su C, Hwang P. Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 2014;155:56-67 pubmed publisher
    ..whether CaSR contributes to body fluid Ca(2+) homeostasis by regulating synthesis of hypercalcemic (PTH1 and PTH2) and hypocalcemic (stanniocalcin [STC]) hormones...
  3. Kwong R, Perry S. An Essential Role for Parathyroid Hormone in Gill Formation and Differentiation of Ion-Transporting Cells in Developing Zebrafish. Endocrinology. 2015;156:2384-94 pubmed publisher
    In vertebrates, parathyroid hormone (PTH) is important for skeletogenesis and Ca(2+) homeostasis...