Gene Symbol: pth1a
Description: parathyroid hormone 1a
Alias: PTH, pth1, parathyroid hormone 1a, parathyroid hormone 1, parathyroid hormone ligand type-1
Species: zebrafish

Top Publications

  1. Huitema L, Renn J, Logister I, Gray J, Waltz S, Flik G, et al. Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB J. 2012;26:4092-101 pubmed publisher
    ..Consistent with a role for Msp/Ron in calcium homeostasis, calcium-regulating factors, such as pth1, pth2, stc1l, and trpv5/6 were significantly affected in msp mutant larvae...
  2. Suarez Bregua P, Cal L, Canestro C, Rotllant J. PTH Reloaded: A New Evolutionary Perspective. Front Physiol. 2017;8:776 pubmed publisher fishes, and based on the evolutionary history of PTH paralogs, we propose a new and simple nomenclature from PTH1 to PTH4...
  3. Hogan B, Danks J, Layton J, Hall N, Heath J, Lieschke G. Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis. Endocrinology. 2005;146:547-51 pubmed
    ..We report the expression patterns of duplicate zebrafish pth genes during embryogenesis. Both zebrafish pth1 and pth2 transcripts are expressed along the lateral line before the migration of the lateral line primordium and ..
  4. Papasani M, Gensure R, Yan Y, Gunes Y, Postlethwait J, Ponugoti B, et al. Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39. Endocrinology. 2004;145:5294-304 pubmed
    Although the PTH type 2 receptor (PTH2R) has been isolated from mammals and zebrafish, only its mammalian agonist, tuberoinfundibular peptide 39 (TIP39), has been characterized thus far...
  5. Hoshijima K, Hirose S. Expression of endocrine genes in zebrafish larvae in response to environmental salinity. J Endocrinol. 2007;193:481-91 pubmed
    ..endocrine genes, including atrial natriuretic peptide (anp), renin, prolactin, growth hormone ( gh) and parathyroid hormone 1 (pth1), respond at the transcription level to changes in environmental salinity and that the responses are ..
  6. Bhattacharya P, Yan Y, Postlethwait J, Rubin D. Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. J Endocrinol. 2011;211:187-200 pubmed publisher
    In mammals, parathyroid hormone (PTH), secreted by parathyroid glands, increases calcium levels in the blood from reservoirs in bone...
  7. Gensure R, Ponugoti B, Gunes Y, Papasani M, Lanske B, Bastepe M, et al. Identification and characterization of two parathyroid hormone-like molecules in zebrafish. Endocrinology. 2004;145:1634-9 pubmed
    Zebrafish (Danio rerio) have receptors homologous to the human PTH (hPTH)/PTHrP receptor (PTH1R) and PTH-2 receptor (PTH2R) and an additional receptor (PTH3R) with high homology to the PTH1R...
  8. Kumai Y, Kwong R, Perry S. A role for transcription factor glial cell missing 2 in Ca2+ homeostasis in zebrafish, Danio rerio. Pflugers Arch. 2015;467:753-65 pubmed publisher
    ..Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac-expressing ionocytes and Ca(2+) uptake. These observations reveal a critical role for gcm2 in Ca(2+) homeostasis in zebrafish larvae. ..
  9. Faria M, Prats E, PadrĂ³s F, Soares A, Raldua D. Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication. Arch Toxicol. 2017;91:1891-1901 pubmed publisher
    ..Our results demonstrated that the zebrafish model for severe acute OP intoxication has a high predictive value and can be used to identify new compounds that provide neuroprotection against severe acute OP intoxication. ..

More Information


  1. Okabe M, Graham A. The origin of the parathyroid gland. Proc Natl Acad Sci U S A. 2004;101:17716-9 pubmed publisher
    ..We also have identified parathyroid hormone 1/2-encoding genes in fish and show that these genes are expressed by the gills...
  2. Yan Y, Bhattacharya P, He X, Ponugoti B, Marquardt B, Layman J, et al. Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. J Endocrinol. 2012;214:421-35 pubmed publisher
    In mammals, parathyroid hormone-related peptide (PTHrP, alias PTH-like hormone (Pthlh)) acts as a paracrine hormone that regulates the patterning of cartilage, bone, teeth, pancreas, and thymus...
  3. Lin C, Su C, Hwang P. Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 2014;155:56-67 pubmed publisher investigate whether CaSR contributes to body fluid Ca(2+) homeostasis by regulating synthesis of hypercalcemic (PTH1 and PTH2) and hypocalcemic (stanniocalcin [STC]) hormones...
  4. Kwong R, Auprix D, Perry S. Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. Am J Physiol Regul Integr Comp Physiol. 2014;306:R211-21 pubmed publisher
    ..Overall, the results suggest that the CaSR is critical for Ca(2+) homeostasis in larval zebrafish exposed to low environmental Ca(2+) levels, possibly owing to its modulation of stanniocalcin mRNA expression. ..
  5. Xu T, Zhao J, Yin D, Zhao Q, Dong B. High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 2015;16:23 pubmed publisher
    ..Other altered genes such as pth1a and collaborative cathepsin family exhibited disrupted bone development, which was consistent with the body ..
  6. Kwong R, Perry S. An Essential Role for Parathyroid Hormone in Gill Formation and Differentiation of Ion-Transporting Cells in Developing Zebrafish. Endocrinology. 2015;156:2384-94 pubmed publisher
    ..Using larval zebrafish as an in vivo model system, we determined that PTH1 regulates the differentiation of epithelial cells and the development of craniofacial cartilage...
  7. Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, et al. A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Hum Genet. 2017;136:835-845 pubmed publisher an extremely rare disorder, which to date has been linked to several loci including mutations in CASR, GCM2, and PTH, as well as a rare condition defined as X-linked recessive hypoparathyroidism, previously associated with a 1...
  8. Renn J, Winkler C, Schartl M, Fischer R, Goerlich R. Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma. 2006;229:209-14 pubmed
    ..Furthermore, it will help to identify novel genes and regulatory pathways of bone homeostasis and skeletal disorders also in higher vertebrates, including disorders caused by altered gravity. ..
  9. Catchen J, Conery J, Postlethwait J. Automated identification of conserved synteny after whole-genome duplication. Genome Res. 2009;19:1497-505 pubmed publisher
    ..To demonstrate the utility of the system, we present a case study of gene family evolution, investigating the ARNTL gene family in the genomes of Ciona intestinalis, amphioxus, zebrafish, and human. ..