Gene Symbol: ptger4a
Description: prostaglandin E receptor 4 (subtype EP4) a
Alias: ptger4, ptger4l, prostaglandin E receptor 4 (subtype EP4) a, PRS4, ep4, ep4a
Species: zebrafish

Top Publications

  1. Cha Y, Kim S, Sepich D, Buchanan F, Solnica Krezel L, DuBois R. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 2006;20:77-86 pubmed
    ..movements of convergence and extension as well as epiboly through the G-protein-coupled PGE(2) receptor (EP4) via phosphatidylinositol 3-kinase (PI3K)/Akt...
  2. North T, Goessling W, Walkley C, Lengerke C, Kopani K, Lord A, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007;447:1007-11 pubmed
    ..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes. ..
  3. Kwok A, Wang Y, Wang C, Leung F. Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4). Gen Comp Endocrinol. 2008;157:99-106 pubmed publisher
    ..Together, our study establishes a molecular basis to understand the physiological roles of PGE(2) in target tissues of chicken. ..
  4. Tsuge K, Iwasaki R, Morimoto K, Inazumi T, Kawahara O, Kawahara A, et al. Molecular and pharmacological characterization of zebrafish 'relaxant' prostanoid receptors. Biochem Biophys Res Commun. 2013;436:685-90 pubmed publisher PGI2 receptor IP and five PGE2 receptors comprising two EP2 (EP2a and EP2b), and three EP4 receptors (EP4a, EP4b and EP4c)...
  5. Poureetezadi S, Cheng C, Chambers J, Drummond B, Wingert R. Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development. elife. 2016;5: pubmed publisher
    ..Disruption of the PGE2 receptors Ptger2a and Ptger4a similarly affected the distal segments...
  6. Nissim S, Sherwood R, Wucherpfennig J, Saunders D, Harris J, Esain V, et al. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Dev Cell. 2014;28:423-37 pubmed publisher
    ..At later stages of development, PGE2 acting via the ep4a receptor promotes outgrowth of both the liver and pancreas...
  7. Iwanami N. Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency. Exp Hematol. 2014;42:697-706 pubmed publisher
    ..Thus, I propose that genetic approaches using the zebrafish hold great potential for a better understanding of molecular mechanisms of human primary immunodeficiencies and the evolution of vertebrate immune systems. ..
  8. Jin D, Ni T, Sun J, Wan H, Amack J, Yu G, et al. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol. 2014;16:841-51 pubmed publisher
    ..PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium ..
  9. Guo T, Gamil A, Koenig M, Evensen Ã. Sequence analysis and identification of new isoform of EP4 receptors in different atlantic salmon tissues (Salmo salar L.) and its role in PGE2 induced immunomodulation in vitro. PLoS ONE. 2015;10:e0120483 pubmed publisher
    ..Orthologous EP receptors have also been identified in other non-mammalian species, such as chicken and zebrafish. EP4 is the only identified PGE2 receptor to date in Atlantic salmon but its tissue distribution and function have not ..

More Information


  1. Villablanca E, Pistocchi A, Court F, Cotelli F, Bordignon C, Allende M, et al. Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos. J Immunol. 2007;179:357-64 pubmed
    ..In this study, we show that zebrafish ep4a, a PGE(2) receptor isoform of EP4, is expressed at 26 h postfertilization in the dorsal aorta-posterior cardinal ..