Gene Symbol: ptger2a
Description: prostaglandin E receptor 2a (subtype EP2)
Alias: ptger2, ptger2l, zgc:63974, prostaglandin E receptor 2a (subtype EP2), PRS2, ep2
Cha Y, Kim S, Sepich D, Buchanan F, Solnica Krezel L, DuBois R. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 2006;20:77-86 pubmed
..This work demonstrates a critical requirement of PGE(2) signaling in promoting cell motility through the COX-1-Ptges-EP4 pathway, a previously unrecognized role for this biologically active lipid in early animal development. ..
Villablanca E, Pistocchi A, Court F, Cotelli F, Bordignon C, Allende M, et al
. Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos. J Immunol. 2007;179:357-64 pubmed
..These results identify ep4a as the earliest thymus marker and define a novel role for the PGE(2)/EP4 pathway in controlling T cell precursor development in zebrafish. ..
North T, Goessling W, Walkley C, Lengerke C, Kopani K, Lord A, et al
. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007;447:1007-11 pubmed
..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes. ..
Kwok A, Wang Y, Wang C, Leung F. Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4). Gen Comp Endocrinol. 2008;157:99-106 pubmed publisher
..Together, our study establishes a molecular basis to understand the physiological roles of PGE(2) in target tissues of chicken. ..
Tsuge K, Iwasaki R, Morimoto K, Inazumi T, Kawahara O, Kawahara A, et al
. Molecular and pharmacological characterization of zebrafish 'relaxant' prostanoid receptors. Biochem Biophys Res Commun. 2013;436:685-90 pubmed publisher
..Gs-coupled) prostanoid receptors in zebrafish; one PGI2 receptor IP and five PGE2 receptors comprising two EP2 (EP2a and EP2b), and three EP4 receptors (EP4a, EP4b and EP4c)...
Nissim S, Sherwood R, Wucherpfennig J, Saunders D, Harris J, Esain V, et al
. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Dev Cell. 2014;28:423-37 pubmed publisher
..This work provides in vivo evidence that PGE2 may act as a morphogen to regulate cell-fate decisions and outgrowth of the embryonic endodermal anlagen. ..
Poureetezadi S, Cheng C, Chambers J, Drummond B, Wingert R. Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development. elife. 2016;5: pubmed publisher
..Disruption of the PGE2 receptors Ptger2a and Ptger4a similarly affected the distal segments...
Morais R, Crespo D, Nóbrega R, Lemos M, van de Kant H, De Franca L, et al
. Antagonistic regulation of spermatogonial differentiation in zebrafish (Danio rerio) by Igf3 and Amh. Mol Cell Endocrinol. 2017;454:112-124 pubmed publisher
..Our data suggest that an important aspect of Fsh bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3. ..