Gene Symbol: prkcz
Description: protein kinase C, zeta
Alias: pkcz, si:ch211-150o23.4, protein kinase C zeta type, atypical protein kinase C zeta
Species: zebrafish
Products:     prkcz

Top Publications

  1. Cui S, Otten C, Rohr S, Abdelilah Seyfried S, Link B. Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. Mol Cell Neurosci. 2007;34:431-44 pubmed
  2. Patten S, Sihra R, Dhami K, Coutts C, Ali D. Differential expression of PKC isoforms in developing zebrafish. Int J Dev Neurosci. 2007;25:155-64 pubmed
    ..Overall, our findings indicate that several different PKC isoforms are expressed in zebrafish, and that Rohon-Beard, Mauthner cells and muscle fibers preferentially express some isoforms over others. ..
  3. Krock B, Perkins B. The Par-PrkC polarity complex is required for cilia growth in zebrafish photoreceptors. PLoS ONE. 2014;9:e104661 pubmed publisher
    ..Thus, the Par-PrkC complex functions in cilia formation in vivo and this likely reflects a general role in specifying non-ciliary and ciliary compartments of the apical domain. ..
  4. Gerlach G, Wingert R. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. Dev Biol. 2014;396:183-200 pubmed publisher
    ..These studies provide a valuable foundation for further analysis of MET during nephrogenesis, and have implications for understanding the pathways that affect nephron epithelial cells during kidney disease and regeneration. ..
  5. Henke K, Daane J, Hawkins M, Dooley C, Busch Nentwich E, Stemple D, et al. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Genetics. 2017;207:609-623 pubmed publisher
    ..Taken together, these results show that dominant screens are a feasible and productive means to identify mutations that can further our understanding of gene function during postembryonic development and in disease. ..
  6. Baye L, Link B. Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. J Neurosci. 2007;27:10143-52 pubmed
  7. Hava D, Forster U, Matsuda M, Cui S, Link B, Eichhorst J, et al. Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. J Cell Sci. 2009;122:687-95 pubmed publisher
  8. Dodd M, Hatzold J, Mathias J, Walters K, Bennin D, Rhodes J, et al. The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development. 2009;136:2591-600 pubmed publisher
  9. Zigman M, Trinh L, Fraser S, Moens C. Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions. Curr Biol. 2011;21:79-86 pubmed publisher

More Information


  1. Wu Y, Liu C, Chen Y, Chen R, Huang C, Wang I. Blood vessel epicardial substance (Bves) regulates epidermal tight junction integrity through atypical protein kinase C. J Biol Chem. 2012;287:39887-97 pubmed publisher
    ..These results indicate that a loss of zBves affects the proteins involved in the pathway of the PAR junctional complex, especially aPKC, and both aPKC and Bves are indispensable to claudin expression. ..
  2. Jung J, Inamdar S, Tiwari A, Ye D, Lin F, Choudhury A. Syntaxin 16 regulates lumen formation during epithelial morphogenesis. PLoS ONE. 2013;8:e61857 pubmed publisher
    ..Taken together, our in vitro and in vivo studies establish a role for Stx16 in maintaining the integrity of cell-cell junctions, and thereby in morphogenesis of the kidney epithelial lumen. ..
  3. Oubaha M, Lin M, Margaron Y, Filion D, Price E, Zon L, et al. Formation of a PKC?/?-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 2012;120:3371-81 pubmed publisher
    ..These results reveal that PKC? and ?-catenin function in a complex at adherens junctions and at the leading edge of migrating endothelial cells to modulate collective and directional migration during angiogenesis. ..
  4. Fitzpatrick P, Shattil S, Ablooglu A. C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. J Biol Chem. 2014;289:11183-93 pubmed publisher
    ..Thus, by employing zebrafish as an in situ physiological tool to correlate protein structure and function, we have discovered an unexpected association chemistry between an integrin and a key adapter involved in integrin signaling. ..