Genomes and Genes
Gene Symbol: prkcz
Description: protein kinase C, zeta
Alias: pkcz, si:ch211-150o23.4, protein kinase C zeta type, atypical protein kinase C zeta
- Wu Y, Liu C, Chen Y, Chen R, Huang C, Wang I. Blood vessel epicardial substance (Bves) regulates epidermal tight junction integrity through atypical protein kinase C. J Biol Chem. 2012;287:39887-97 pubmed publisher..These results indicate that a loss of zBves affects the proteins involved in the pathway of the PAR junctional complex, especially aPKC, and both aPKC and Bves are indispensable to claudin expression. ..
- Jung J, Inamdar S, Tiwari A, Ye D, Lin F, Choudhury A. Syntaxin 16 regulates lumen formation during epithelial morphogenesis. PLoS ONE. 2013;8:e61857 pubmed publisher..Taken together, our in vitro and in vivo studies establish a role for Stx16 in maintaining the integrity of cell-cell junctions, and thereby in morphogenesis of the kidney epithelial lumen. ..
- Oubaha M, Lin M, Margaron Y, Filion D, Price E, Zon L, et al. Formation of a PKC?/?-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 2012;120:3371-81 pubmed publisher..These results reveal that PKC? and ?-catenin function in a complex at adherens junctions and at the leading edge of migrating endothelial cells to modulate collective and directional migration during angiogenesis. ..
- Fitzpatrick P, Shattil S, Ablooglu A. C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. J Biol Chem. 2014;289:11183-93 pubmed publisher..Thus, by employing zebrafish as an in situ physiological tool to correlate protein structure and function, we have discovered an unexpected association chemistry between an integrin and a key adapter involved in integrin signaling. ..