Gene Symbol: prickle1a
Description: prickle homolog 1a
Alias: fk71b09, pk1, prickle1, wu:fk71b09, prickle homolog 1a, pk1a, prickle-like 1 a
Species: zebrafish
Products:     prickle1a

Top Publications

  1. Veeman M, Slusarski D, Kaykas A, Louie S, Moon R. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol. 2003;13:680-5 pubmed
    ..Both gain and loss of pk1 function cause defects in convergent extension...
  2. Carreira Barbosa F, Concha M, Takeuchi M, Ueno N, Wilson S, Tada M. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development. 2003;130:4037-46 pubmed
    ..Zebrafish pk1 is expressed maternally and in moving mesodermal precursors...
  3. Ciruna B, Jenny A, Lee D, Mlodzik M, Schier A. Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature. 2006;439:220-4 pubmed
    ..These results reveal a function for PCP signalling in coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mechanism that might underlie NTDs. ..
  4. Rohrschneider M, Elsen G, Prince V. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007;309:358-72 pubmed
    ..Using morpholino knock-down and cell transplantation, we demonstrate that the Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity. ..
  5. Mapp O, Wanner S, Rohrschneider M, Prince V. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Dev Dyn. 2010;239:1596-608 pubmed publisher
    ..Together, our data suggest that Pk1b function may be required to integrate the multiple migratory cues received by the neurons into polarization instructions for proper posterior movement. ..
  6. Bosoi C, Capra V, Allache R, Trinh V, De Marco P, Merello E, et al. Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects. Hum Mutat. 2011;32:1371-5 pubmed publisher
    ..Arg682Cys, antagonized the CE phenotype induced by the wild-type zebrafish prickle1a (zpk1a) in a dominant fashion...
  7. Bassuk A, Wallace R, Buhr A, Buller A, Afawi Z, Shimojo M, et al. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet. 2008;83:572-81 pubmed publisher
    ..This report identifies a mutation in PRICKLE1 (also known as RILP for REST/NRSF interacting LIM domain protein) in all three of these pedigrees...
  8. Dutta S, Sriskanda S, Boobalan E, Alur R, Elkahloun A, Brooks B. nlz1 is required for cilia formation in zebrafish embryogenesis. Dev Biol. 2015;406:203-11 pubmed publisher
    ..Furthermore, Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt signaling. Together, our data suggest a novel role of nlz1 in ciliogenesis and the morphogenesis of multiple tissues. ..
  9. Kishimoto N, Cao Y, Park A, Sun Z. Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev Cell. 2008;14:954-61 pubmed publisher
    ..Finally, we show that seahorse constrains the canonical Wnt pathway and promotes the noncanonical Wnt pathway during gastrulation. Together, these data suggest that Seahorse may provide a link between ciliary signals and Wnt pathways. ..

More Information


  1. Dohn M, Mundell N, Sawyer L, Dunlap J, Jessen J. Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev Biol. 2013;383:39-51 pubmed publisher
    ..Here we report that similar to vangl2, loss of zebrafish prickle1a decreases fibronectin protein levels in gastrula embryos...
  2. Walsh G, Grant P, Morgan J, Moens C. Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration. Development. 2011;138:3033-42 pubmed publisher
    ..These results define a role for Nhsl1b as a neuronal effector of PCP signaling and indicate that proper FBM neuron migration is directly controlled by PCP signaling between the epithelium and the migrating neurons. ..
  3. Reeves W, Wu Y, Harder M, Veeman M. Functional and evolutionary insights from the Ciona notochord transcriptome. Development. 2017;144:3375-3387 pubmed publisher
  4. Mei X, Wu S, Bassuk A, Slusarski D. Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. Dis Model Mech. 2013;6:679-88 pubmed publisher
    ..However, a recent screening in human epilepsy patients identified mutations in the PRICKLE1 (PK1) locus, highlighting a potentially novel mechanism underlying seizures...
  5. Liu X, Ning G, Meng A, Wang Q. MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation. Mol Cell Biol. 2012;32:2934-42 pubmed publisher
    ..Mechanistically, mir206 targets prickle1a (pk1a) mRNA and as a result regulates c-Jun N-terminal protein kinase 2 (JNK2) phosphorylation...
  6. Cui S, Capecci L, Matthews R. Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol. 2011;351:229-41 pubmed publisher
    ..that in zebrafish, morpholino antisense oligonucleotide-mediated knockdown of PCP genes including prickle-1a (pk1a) led to developmental biliary abnormalities, as well as localization defects of the liver and other digestive ..
  7. Oteiza P, Köppen M, Krieg M, Pulgar E, Farias C, Melo C, et al. Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development. 2010;137:3459-68 pubmed publisher
    ..Here, we show that Wnt11- and Prickle1a-mediated planar cell polarity (PCP) signalling coordinates the formation of the zebrafish ciliated laterality ..
  8. Cao Y, Park A, Sun Z. Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity. J Am Soc Nephrol. 2010;21:1326-33 pubmed publisher
    ..Depletion of pk1, a core PCP component, similarly led to kidney cyst formation and basal body disorganization...
  9. Tawk M, Araya C, Lyons D, Reugels A, Girdler G, Bayley P, et al. A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature. 2007;446:797-800 pubmed
  10. Dingwell K, Smith J. Tes regulates neural crest migration and axial elongation in Xenopus. Dev Biol. 2006;293:252-67 pubmed
  11. Panàkovà D, Werdich A, Macrae C. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 2010;466:874-8 pubmed publisher
    ..The regulation of cellular coupling through such mechanisms may be a general property of non-canonical Wnt signals. ..
  12. Sarras M, Leontovich A, Olsen A, Intine R. Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish. Wound Repair Regen. 2013;21:320-8 pubmed publisher
    ..The aberrant expression of key regulatory genes in the DM state that persist into the MM state provides a plausible explanation on how hyperglycemia induced impaired fin regeneration in the adult zebrafish DM/MM model. ..
  13. Jerber J, Baas D, Soulavie F, Chhin B, Cortier E, Vesque C, et al. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Hum Mol Genet. 2014;23:563-77 pubmed publisher
    ..ccdc151 is involved in proper orientation of cell divisions in the pronephros and genetically interacts with prickle1 in this process...
  14. Yang T, Bassuk A, Stricker S, Fritzsch B. Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons. Cell Tissue Res. 2014;357:549-61 pubmed publisher
    ..In zebrafish and mouse, mutations in certain PCP genes disrupt normal caudal migration of FBMs. Zebrafish prickle1a (prickle-like 1a) and prickle1b, two orthologs of Prickle1, act non-cell-autonomously and cell-autonomously, ..