Gene Symbol: prdx1
Description: peroxiredoxin 1
Alias: hm:zehl0637, zgc:110343, peroxiredoxin-1
Species: zebrafish
Products:     prdx1

Top Publications

  1. Song Y, Wu B, Chiu C, Chen C, Zhou J, Liang S, et al. Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, exogenous N-acetyl-cysteine (NAC) treatment rescued the vascular defects in GB9 treated embryos. Our results showed that GB9 exposure causes vascular defects likely mediated by the imbalance of redox homeostasis. ..
  2. Mukaigasa K, Nguyen L, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mol Cell Biol. 2012;32:4455-61 pubmed publisher
  3. Wang L, Gallagher E. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicol Appl Pharmacol. 2013;266:177-86 pubmed publisher
    ..S-transferase pi (gst pi), glutamate-cysteine ligase catalytic subunit (gclc), heme oxygenase 1 (hmox1) and peroxiredoxin 1 (prdx1) mRNA levels indicative of Nrf2 activation, and which were blocked by morpholino-mediated Nrf2 ..
  4. Jeon H, Lee Y, Kim M, Choi S, Park B, Lee S. Integrated biomarkers induced by chlorpyrifos in two different life stages of zebrafish (Danio rerio) for environmental risk assessment. Environ Toxicol Pharmacol. 2016;43:166-74 pubmed publisher
    ..Our results suggest that the up-regulation of metabolic enzymes including CYP450 and MDR1 may be involved in CHL resistance in zebrafish. ..
  5. Huang P, Chiu C, Chang H, Wang Y, Syue H, Song Y, et al. Prdx1-encoded peroxiredoxin is important for vascular development in zebrafish. FEBS Lett. 2017;591:889-902 pubmed publisher
    ..Here, we report a novel function of peroxiredoxin1 (Prdx1) in vascular development in zebrafish...
  6. Yang L, Kemadjou J, Zinsmeister C, Bauer M, Legradi J, Muller F, et al. Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biol. 2007;8:R227 pubmed
    ..Our work provides proof-of-principle for the use of the zebrafish embryo as a toxicogenomic model and highlights its potential for systematic, large-scale analysis of the effects of chemicals on the developing vertebrate embryo. ..
  7. Liu Q, Basu N, Goetz G, Jiang N, Hutz R, Tonellato P, et al. Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology. 2013;22:740-51 pubmed publisher
    ..Our conclusion is that biomarker analysis for aquatic toxicant assessment using fish needs to be based on tissue-, sex- and species-specific consideration. ..
  8. Fuse Y, Nakajima H, Nakajima Takagi Y, Nakajima O, Kobayashi M. Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes Cells. 2015;20:590-600 pubmed publisher
    ..Our results suggested that Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue. ..
  9. Newman T, Carleton C, Leeke B, Hampton M, Horsfield J. Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biol. 2015;6:648-55 pubmed publisher
    ..Auranofin at low doses triggered upregulation of the antioxidant genes gstp1 and prdx1. As the dose was increased, acute developmental abnormalities, including cerebral hemorrhaging and jaw ..

More Information


  1. Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher
    ..Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury. ..
  2. Leyk J, Daly C, Janssen Bienhold U, Kennedy B, Richter Landsberg C. HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness. Cell Death Dis. 2017;8:e3028 pubmed publisher
    ..Furthermore, in response to oxidative stress the redox regulatory protein peroxiredoxin 1 (Prx1) was modulated in 661W cells by HDAC6 inhibition...
  3. Henry T, Menn F, Fleming J, Wilgus J, Compton R, Sayler G. Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Environ Health Perspect. 2007;115:1059-65 pubmed
    ..Previous research has indicated toxicity from C(60) aggregate; however, effects could be because of tetrahydrofuran (THF) vehicle used to prepare aggregates...
  4. Cox A, Saunders D, Kelsey P, Conway A, Tesmenitsky Y, Marchini J, et al. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014;6:56-69 pubmed publisher
    ..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury...
  5. Rainieri S, Conlledo N, Langerholc T, Madorran E, Sala M, Barranco A. Toxic effects of perfluorinated compounds at human cellular level and on a model vertebrate. Food Chem Toxicol. 2017;104:14-25 pubmed publisher
    ..This study highlights the importance of studying PFCs in realistic conditions on various biological models. ..
  6. Yang L, Ho N, Muller F, Strahle U. Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Toxicol Sci. 2010;115:379-90 pubmed publisher
    ..Our data suggest that MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13. ..