ppiab

Summary

Gene Symbol: ppiab
Description: peptidylprolyl isomerase Ab (cyclophilin A)
Alias: ppial, wu:fj18g05, zgc:73102, zgc:86688, peptidyl-prolyl cis-trans isomerase A, cyclophilin, peptidylprolyl isomerase A, like
Species: zebrafish

Top Publications

  1. Zakrzewska A, Cui C, Stockhammer O, Benard E, Spaink H, Meijer A. Macrophage-specific gene functions in Spi1-directed innate immunity. Blood. 2010;116:e1-11 pubmed publisher
    ..Therefore, based on our combined transcriptome analyses, we discovered novel early macrophage-specific marker genes, including a signal transducer pivotal for macrophage migration in the innate immune response. ..
  2. van der Vaart M, van Soest J, Spaink H, Meijer A. Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Dis Model Mech. 2013;6:841-54 pubmed publisher
    ..This zebrafish myd88 mutant will be a valuable tool for further study of the role of IL1R and TLR signaling in the innate immunity processes underlying infectious diseases, inflammatory disorders and cancer...
  3. Stockhammer O, Zakrzewska A, Hegedus Z, Spaink H, Meijer A. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. J Immunol. 2009;182:5641-53 pubmed publisher
    ..Finally, we showed that induction of il1b, mmp9, and irak3 requires Myd88-dependent signaling, while ifn1 and il8 were induced Myd88 independently during Salmonella infection. ..
  4. Torraca V, Cui C, Boland R, Bebelman J, van der Sar A, Smit M, et al. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Dis Model Mech. 2015;8:253-69 pubmed publisher
    ..The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system. ..
  5. van der Vaart M, Korbee C, Lamers G, Tengeler A, Hosseini R, Haks M, et al. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]. Cell Host Microbe. 2014;15:753-67 pubmed publisher
    ..We propose that DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide. ..
  6. Mesureur J, Feliciano J, Wagner N, Gomes M, Zhang L, Blanco Gonzalez M, et al. Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS Pathog. 2017;13:e1006437 pubmed publisher
    ..We suggest that paradigm-changing approaches are needed for development of novel antimicrobials to efficiently disarm intracellular bacteria of this group of highly persistent, opportunistic pathogens. ..
  7. Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
    ..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism. ..
  8. Yang S, Marín Juez R, Meijer A, Spaink H. Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. BMC Genomics. 2015;16:547 pubmed publisher
    ..Our studies show that Pam3CSK4 and flagellin can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system. ..
  9. Fink I, Benard E, Hermsen T, Meijer A, Forlenza M, Wiegertjes G. Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. Mol Immunol. 2015;63:381-93 pubmed publisher
    ..We discuss the putative role for Cd36 in immune responses of fish in the context of other members of the scavenger receptor class B family. ..

More Information

Publications19

  1. Marín Juez R, Jong Raadsen S, Yang S, Spaink H. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. J Endocrinol. 2014;222:229-41 pubmed publisher
    ..In addition, our data will be very useful in further studies of the function of immunological determinants in a non-obese model system. ..
  2. Ordas A, Kanwal Z, Lindenberg V, Rougeot J, Mink M, Spaink H, et al. MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection. BMC Genomics. 2013;14:696 pubmed publisher
    ..In contrast, apolipoprotein-mediated lipid transport emerged as an infection-inducible pathway under miR-146 knockdown conditions, suggesting a possible function of miR-146 in regulating lipid metabolism during inflammation...
  3. Gebriel M, Prabhudesai S, Uleberg K, Larssen E, Piston D, Bjørnstad A, et al. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. J Neurosci Res. 2014;92:104-15 pubmed publisher
  4. Jiménez Amilburu V, Jong Raadsen S, Bakkers J, Spaink H, Marín Juez R. GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish. J Endocrinol. 2015;224:1-15 pubmed publisher
    ..In addition, the diabetic phenotype displayed by these larvae after glut12 abrogation highlights the importance of this GLUT during early developmental stages. ..
  5. Muto A, Taylor M, Suzawa M, Korenbrot J, Baier H. Glucocorticoid receptor activity regulates light adaptation in the zebrafish retina. Front Neural Circuits. 2013;7:145 pubmed publisher
    ..We suggest that GR controls a gene network required for visual adaptation in the zebrafish retina and potentially integrates neuroendocrine and sensory responses to environmental changes. ..
  6. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
  7. Biava P, Canaider S, Facchin F, Bianconi E, Ljungberg L, Rotilio D, et al. Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. Curr Pharm Biotechnol. 2015;16:782-92 pubmed
    ..In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration. ..
  8. Eb Levadoux Y, Frelon S, Simon O, Arnaudguilhem C, Lobinski R, Mounicou S. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Metallomics. 2017;9:525-534 pubmed publisher
    ..Potential U targets were mainly involved in three biological processes: oxidative stress regulation (SOD, GST), cytoskeleton structure (actin) and embryo early development (vtg, initiation factor). ..
  9. Torraca V, Tulotta C, Snaar Jagalska B, Meijer A. The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Sci Rep. 2017;7:45061 pubmed publisher
    ..Expression of vegfaa was upregulated to a similar extent in cxcr4b mutants and wildtypes, suggesting that the granuloma vascularisation phenotype of cxcr4b mutants is independent of vascular endothelial growth factor. ..
  10. Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
    ..Globin X mRNA level was highest in oocytes, but low in later stages. Together, these data suggest a specific role for each globin, which are also associated with certain events in fish development. ..