Gene Symbol: ppiaa
Description: peptidylprolyl isomerase Aa (cyclophilin A)
Alias: Cyp1, PPIA-2, fa93g09, ppia, wu:fa93g09, wu:fb05e11, wu:fb13h02, wu:fb15a05, peptidyl-prolyl cis-trans isomerase A, peptidylprolyl isomerase A (cyclophilin A)
Species: zebrafish

Top Publications

  1. Faria M, Prats E, Padrós F, Soares A, Raldua D. Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication. Arch Toxicol. 2017;91:1891-1901 pubmed publisher
    ..Our results demonstrated that the zebrafish model for severe acute OP intoxication has a high predictive value and can be used to identify new compounds that provide neuroprotection against severe acute OP intoxication. ..
  2. Oliveira E, Casado M, Raldua D, Soares A, Barata C, Pina B. Retinoic acid receptors' expression and function during zebrafish early development. J Steroid Biochem Mol Biol. 2013;138:143-51 pubmed publisher
    ..We conclude that zebrafish embryos are particularly sensitive to potential disruptors of the RAR/RXR regulatory system. ..
  3. Tingaud Sequeira A, Raldúa D, Lavie J, Mathieu G, Bordier M, Knoll Gellida A, et al. Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiol Dis. 2017;98:36-51 pubmed publisher
    ..Zebrafish may provide a suitable vertebrate model for ABHD12 insufficiency and the study of functional impairment and potential therapeutic rescue of this rare, neurodegenerative disease. ..
  4. Mesquita S, van Drooge B, Oliveira E, Grimalt J, Barata C, Vieira N, et al. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environ Pollut. 2015;206:535-42 pubmed publisher
    ..The observed effects can be directly related to air pollution-related human disorders, suggesting different potential adverse outcomes for human populations exposed to air pollution from specific sources. ..
  5. Biava P, Canaider S, Facchin F, Bianconi E, Ljungberg L, Rotilio D, et al. Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. Curr Pharm Biotechnol. 2015;16:782-92 pubmed
    ..In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration. ..
  6. Oliveira I, Groh K, Schönenberger R, Barroso C, Thomas K, Suter M. Toxicity of emerging antifouling biocides to non-target freshwater organisms from three trophic levels. Aquat Toxicol. 2017;191:164-174 pubmed publisher
    ..Noneless, more studies on the characterization of the toxicity, behaviour and fate of these AF biocides in the environment are necessary since this information directly affects the outcome of the risk assessment. ..
  7. Eb Levadoux Y, Frelon S, Simon O, Arnaudguilhem C, Lobinski R, Mounicou S. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Metallomics. 2017;9:525-534 pubmed publisher
    ..Potential U targets were mainly involved in three biological processes: oxidative stress regulation (SOD, GST), cytoskeleton structure (actin) and embryo early development (vtg, initiation factor). ..
  8. Esteves A, Knoll Gellida A, Canclini L, Silvarrey M, André M, Babin P. Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei. J Lipid Res. 2016;57:219-32 pubmed publisher
    ..These data suggest that dietary FAs complexed with FABPs are able to reach the enterocyte nucleus with the potential to modulate nuclear activity. ..
  9. Hasumura T, Shimada Y, Kuroyanagi J, Nishimura Y, Meguro S, Takema Y, et al. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutr Metab (Lond). 2012;9:73 pubmed publisher
    ..Our results suggest that GTE exerts beneficial effects on adiposity, possibly by altering the expression of lipid catabolism genes and SOCS3. ..

More Information


  1. Jones K, Alimov A, Rilo H, Jandacek R, Woollett L, Penberthy W. A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development. Nutr Metab (Lond). 2008;5:23 pubmed publisher
    ..Furthermore data supports future studies focused on determining whether there is a high concentration window for resveratrol that is effective and non-toxic in high fat obesity murine models. ..
  2. Olivares A, van Drooge B, Casado M, Prats E, Serra M, van der Ven L, et al. Developmental effects of aerosols and coal burning particles in zebrafish embryos. Environ Pollut. 2013;178:72-9 pubmed publisher
    ..This sample induced deformities in zebrafish embryos. We concluded that the combination of morphological and molecular assays may detect embryonic toxic effects that cannot be predicted from chemical analyses or single-cell bioassays. ..
  3. Pelayo S, Oliveira E, Thienpont B, Babin P, Raldua D, André M, et al. Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: implications for bisphenol A developmental toxicity. Aquat Toxicol. 2012;110-111:114-22 pubmed publisher
  4. Wang H, Zhou Q, Kesinger J, Norris C, Valdez C. Heme regulates exocrine peptidase precursor genes in zebrafish. Exp Biol Med (Maywood). 2007;232:1170-80 pubmed
    ..Our findings provide a better understanding of heme deficiency pathogenesis and enhance our ability to diagnose and treat patients with porphyria or pancreatic diseases. ..
  5. Morais S, Knoll Gellida A, André M, Barthe C, Babin P. Conserved expression of alternative splicing variants of peroxisomal acyl-CoA oxidase 1 in vertebrates and developmental and nutritional regulation in fish. Physiol Genomics. 2007;28:239-52 pubmed
    ..Taken together, these data indicate that ACOX1 alternative splicing isoforms play a key conserved role in the vertebrate fatty acid metabolism. ..
  6. Sato A, Takeda H. Neuronal subtypes are specified by the level of neurod expression in the zebrafish lateral line. J Neurosci. 2013;33:556-62 pubmed publisher
    ..These results suggest that the quantity, rather than quality (i.e., the ON/OFF states), of neurod expression directly or indirectly determines the two subtypes of PLL neurons. ..
  7. Tingaud Sequeira A, Knoll Gellida A, André M, Babin P. Vitellogenin expression in white adipose tissue in female teleost fish. Biol Reprod. 2012;86:38 pubmed publisher
    ..These findings suggest that WAT Vtg is implicated in providing components to the ovary during the early stages of vitellogenesis. ..
  8. Mazzeo D, Casado M, Piña B, Marin Morales M. Detoxification of sewage sludge by natural attenuation and implications for its use as a fertilizer on agricultural soils. Sci Total Environ. 2016;572:978-985 pubmed publisher
    ..It also shows that this potential impact may be significantly mitigated by attenuation protocols, as the one presented here. ..
  9. Schuck J, Sun H, Penberthy W, Cooper N, Li X, Smith M. Transcriptomic analysis of the zebrafish inner ear points to growth hormone mediated regeneration following acoustic trauma. BMC Neurosci. 2011;12:88 pubmed publisher
    ..GH injection increased cell proliferation in the inner ear of non-sound-exposed zebrafish, suggesting that GH could play an important role in sensory hair cell regeneration in the teleost ear. ..