Gene Symbol: pou5f3
Description: POU domain, class 5, transcription factor 3
Alias: POU-2, cb197, chunp6868, etID49452.21, gp-9, gp9, oct4, pou2, pou5f1, spg, spg/pou2, wu:fd18d06, POU domain, class 5, transcription factor 1, POU domain gene 2, POU domain protein 2, spiel-ohne-grenzen, spiel-ohne-grenzen/pou2
Species: zebrafish
Products:     pou5f3

Top Publications

  1. Morrison G, Brickman J. Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development. Development. 2006;133:2011-22 pubmed
    ..ES cells are derived from mammalian inner cell mass (ICM) tissue that express the Class V POU domain (PouV) protein Oct4. Loss of Oct4 in mice results in a failure to maintain ICM and consequently an inability to derive ES cells...
  2. Rhinn M, Lun K, Amores A, Yan Y, Postlethwait J, Brand M. Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling. Mech Dev. 2003;120:919-36 pubmed
    ..Analysis of gbx1 and gbx2 expression during formation of the MHB in mutant embryos for pax2.1, fgf8 and pou2 (noi, ace, spg), as well as Fgf-inhibition experiments, show that gbx1 acts upstream of these genes in MHB ..
  3. Reim G, Mizoguchi T, Stainier D, Kikuchi Y, Brand M. The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Dev Cell. 2004;6:91-101 pubmed
    ..Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation...
  4. Lindeman L, Winata C, Aanes H, Mathavan S, Alestrom P, Collas P. Chromatin states of developmentally-regulated genes revealed by DNA and histone methylation patterns in zebrafish embryos. Int J Dev Biol. 2010;54:803-13 pubmed publisher
    ..We report here DNA methylation and histone modification profiles of promoters of developmentally-regulated genes (pou5f1, sox2, sox3, klf4, nnr, otx1b, nes, vasa), as well as tert and bactin2, in zebrafish embryos at the mid-late ..
  5. Rodriguez Mari A, Wilson C, Titus T, Canestro C, Bremiller R, Yan Y, et al. Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish. PLoS Genet. 2011;7:e1001357 pubmed publisher
    ..Oocytes in double-mutant females showed normal localization of brca2 and pou5f1 transcripts to the animal pole and vasa transcripts to the vegetal pole, but had a polarized rather than ..
  6. Marlow F, Mullins M. Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish. Dev Biol. 2008;321:40-50 pubmed publisher
    ..Finally, the expansion of animal identity in oocytes and somatic follicle cells suggests that somatic cell fate and oocyte polarity are interdependent. ..
  7. Lachnit M, Kur E, Driever W. Alterations of the cytoskeleton in all three embryonic lineages contribute to the epiboly defect of Pou5f1/Oct4 deficient MZspg zebrafish embryos. Dev Biol. 2008;315:1-17 pubmed publisher
    ..Zebrafish pou5f1 deficient maternal and zygotic spiel ohne grenzen (MZspg) mutant embryos develop severe gastrulation defects, are dorsalized, and defective in endoderm ..
  8. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..It is unknown whether a similar regulation exists in other animals. We found that zebrafish Pou5f1, a homolog of the mammalian pluripotency transcription factor Oct4, occupies SOX-POU binding sites before the ..
  9. Fukuda K, Kikuchi Y. Endoderm development in vertebrates: fate mapping, induction and regional specification. Dev Growth Differ. 2005;47:343-55 pubmed
    ..We discuss the classical fate mapping of the endoderm and the more recent progress in characterizing its induction, segregation and regional specification. ..

More Information


  1. Vesterlund L, Jiao H, Unneberg P, Hovatta O, Kere J. The zebrafish transcriptome during early development. BMC Dev Biol. 2011;11:30 pubmed publisher
    ..Taken together, these observations indicate a major transition in gene regulation and transcriptional activity taking place between the 512-cell and 50% epiboly stages, in accordance with previous studies. ..
  2. Howley C, Ho R. mRNA localization patterns in zebrafish oocytes. Mech Dev. 2000;92:305-9 pubmed
    ..Unique patterns of localization are seen in mature eggs as well. Some mRNAs maintain their oocyte localization patterns, while others localize upon egg activation (fertilization). ..
  3. Song S, Eckerle S, Onichtchouk D, Marrs J, Nitschke R, Driever W. Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Dev Cell. 2013;24:486-501 pubmed publisher
    ..We show that, in zebrafish maternal and zygotic (MZ)spg embryos mutant for the stem cell transcription factor Pou5f1/Oct4, which are severely delayed in the epiboly gastrulation movement, all blastomeres are defective in E-cadherin ..
  4. Belting H, Wendik B, Lunde K, Leichsenring M, Mössner R, Driever W, et al. Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression. Dev Biol. 2011;356:323-36 pubmed publisher
    ..Zebrafish pou5f1 maternal-zygotic mutant embryos (spiel ohne grenzen; MZspg) lack endoderm and have gastrulation and dorsoventral patterning defects...
  5. Lunde K, Belting H, Driever W. Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade. Curr Biol. 2004;14:48-55 pubmed
    ..In zebrafish, the zygotic pou5f1/pou2 mutant spiel ohne grenzen (spg) shows neural plate patterning defects and reduced endoderm at the tailbud stage...
  6. Chan T, Chao C, Wang H, Yu Y, Yuh C. Functional analysis of the evolutionarily conserved cis-regulatory elements on the sox17 gene in zebrafish. Dev Biol. 2009;326:456-70 pubmed publisher
    ..experiments and literature search, the sox17 gene is engaged with two other regulatory genes, sox32 and pou5f1. Nodal signaling operated on several endoderm-specific transcription factors to determine the endoderm ..
  7. Onichtchouk D, Geier F, Polok B, Messerschmidt D, Mössner R, Wendik B, et al. Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development. Mol Syst Biol. 2010;6:354 pubmed publisher
    The transcription factor POU5f1/OCT4 controls pluripotency in mammalian ES cells, but little is known about its functions in the early embryo...
  8. Zhao J, Lambert G, Meijer A, Rosa F. The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2. Development. 2013;140:1090-9 pubmed publisher
    ..acts downstream of the Nodal signal, is essential for endoderm development and requires the co-factor Pou2 (Pou5f1, Oct3, Oct4) in this process...
  9. Almeida R, Loose M, Sottile V, Matsa E, Denning C, Young L, et al. 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics. 2012;7:383-9 pubmed publisher
    ..Our findings show that 5-hmC enrichment of non-committed cells is not a universal feature of vertebrate development and give insights both into evolution of embryonic pluripotency and the potential role of 5-hmC in its regulation. ..
  10. Arulmozhivarman G, Kräter M, Wobus M, Friedrichs J, Bejestani E, Muller K, et al. Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells. Sci Rep. 2017;7:12084 pubmed publisher
  11. Wu S, Zhang H, Cairns B. Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res. 2011;21:578-89 pubmed publisher
    ..Taken together, gene sets with particular functions in the embryo are packaged by distinctive types of complex and often atypical chromatin in sperm. ..
  12. Kato H, Abe K, Yokota S, Matsuno R, Mikekado T, Yokoi H, et al. Establishment of oct4:gfp transgenic zebrafish line for monitoring cellular multipotency by GFP fluorescence. In Vitro Cell Dev Biol Anim. 2015;51:42-9 pubmed publisher
    ..In order to apply iPS cell technology to fish, we established a transgenic zebrafish line, Tg(Tru.oct4:EGFP), using green fluorescent protein (GFP) expression under the control of the oct4 gene promoter as a marker to ..
  13. Hui S, Nag T, Ghosh S. Characterization of Proliferating Neural Progenitors after Spinal Cord Injury in Adult Zebrafish. PLoS ONE. 2015;10:e0143595 pubmed publisher
    ..Among the several key factors related to pluripotency, pou5f1 and sox2 are upregulated during regeneration and associated with activation of neural progenitor cells...
  14. Liu X, Cai X, Hu B, Mei Z, Zhang D, Ouyang G, et al. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). J Biol Chem. 2016;291:25692-25705 pubmed
    ..In conclusion, our findings suggest that, by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress. ..
  15. Spaniol P, Bornmann C, Hauptmann G, Gerster T. Class III POU genes of zebrafish are predominantly expressed in the central nervous system. Nucleic Acids Res. 1996;24:4874-81 pubmed
    ..Analysis of the expression of the class III genes shows that they are predominantly expressed in the central nervous system and that they may play important roles in patterning the embryonic brain. ..
  16. Albuixech Crespo B, López Blanch L, Burguera D, Maeso I, Sánchez Arrones L, Moreno Bravo J, et al. Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biol. 2017;15:e2001573 pubmed publisher
    ..This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice. ..
  17. Mohapatra C, Patra S, Panda R, Mohanta R, Saha A, Saha J, et al. Gene structure and identification of minimal promoter of Pou2 expressed in spermatogonial cells of rohu carp, Labeo rohita. Mol Biol Rep. 2014;41:4123-32 pubmed publisher
    Mammalian Pou5f1 is a known transcriptional regulator involving maintenance of embryonic and spermatogonial stem cells. Little is known about teleost Pou2, an ortholog of mammalian Pou5f1...
  18. Sun D, Zhang Y, Wang C, Hua X, Zhang X, Yan J. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death Dis. 2013;4:e930 pubmed publisher
  19. Ye H, Du H, Chen X, Cao H, Liu T, Li C. Identification of a pou2 ortholog in Chinese sturgeon, Acipenser sinensis and its expression patterns in tissues, immature individuals and during embryogenesis. Fish Physiol Biochem. 2012;38:929-942 pubmed publisher
    The class V POU family genes, including pou5f1 and pou2, encode transcription factors critical for the maintenance of pluripotency in embryonic stem cells (ESC) and germ line cells in vertebrates...
  20. Xiao Y, Gao M, Gao L, Zhao Y, Hong Q, Li Z, et al. Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016;7:370-382 pubmed publisher
    ..The technology provides a new platform for the study of heart development and regeneration, in addition to drug discovery, disease modeling, and assessment of cardiotoxic agents. ..
  21. Schuff M, Siegel D, Philipp M, Bundschu K, Heymann N, Donow C, et al. Characterization of Danio rerio Nanog and functional comparison to Xenopus Vents. Stem Cells Dev. 2012;21:1225-38 pubmed publisher
    ..Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog...
  22. Du S, Draper B, Mione M, Moens C, Bruce A. Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A. Dev Biol. 2012;362:11-23 pubmed publisher
    ..We also show that Eomesa is required for normal expression of the endoderm markers sox32, bon and og9x; however it is not essential for endoderm formation. ..
  23. Riesco M, Robles V. Cryopreservation Causes Genetic and Epigenetic Changes in Zebrafish Genital Ridges. PLoS ONE. 2013;8:e67614 pubmed publisher
    ..results indicated that cryopreservation produced a decrease in most of the zebrafish studied transcripts (cxcr4b, pou5f1, vasa and sox2) and upregulation of heat shock proteins (hsp70, hsp90)...
  24. Riley B, Chiang M, Storch E, Heck R, Buckles G, Lekven A. Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev Dyn. 2004;231:278-91 pubmed
    ..Similar patterning defects are observed in segmentation mutants spiel-ohne-grenzen (spg) and valentino (val), which fail to form rhombomere boundaries due to faulty interactions between adjacent ..
  25. Frankenberg S, Frank D, Harland R, Johnson A, Nichols J, Niwa H, et al. The POU-er of gene nomenclature. Development. 2014;141:2921-3 pubmed publisher
    ..of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks ..
  26. Rossell R, Chen C, Dai R, Howard J, Hochgeschwender U, Jarvis E. Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. elife. 2013;2:e00036 pubmed publisher
    ..We suggest that the stem-cell state may be highly conserved across a wide phylogenetic range. DOI:http://dx.doi.org/10.7554/eLife.00036.001...
  27. Iwafuchi Doi M, Yoshida Y, Onichtchouk D, Leichsenring M, Driever W, Takemoto T, et al. The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates. Dev Biol. 2011;352:354-66 pubmed publisher
    ..The major POU factor expressed at the epiblastic stage is Pou5f1 (Oct3/4), while those in the anterior neural plate are Pou3f factors (Oct6, Brn2 etc.)...
  28. Hartung O, Forbes M, Marlow F. Zebrafish vasa is required for germ-cell differentiation and maintenance. Mol Reprod Dev. 2014;81:946-61 pubmed publisher
    ..Our studies provide insight into the function of zebrafish vasa during female meiosis, differentiation, and maintenance of germ-line stem cells. ..
  29. Kotkamp K, Kur E, Wendik B, Polok B, Ben Dor S, Onichtchouk D, et al. Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PLoS ONE. 2014;9:e92356 pubmed publisher
    ..Here we investigated the control of myc gene expression by the Pou5f1/Oct4 pluripotency factor in the early zebrafish embryo...
  30. Sambrook J, Figueroa F, Beck S. A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish. BMC Genomics. 2005;6:152 pubmed
    ..Although based on a draft genome assembly, this survey demonstrates an essentially fragmented MHC in zebrafish. ..
  31. Guo Y, Ma L, Cristofanilli M, Hart R, Hao A, Schachner M. Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish. Neuroscience. 2011;172:329-41 pubmed publisher
    ..Enhancing Sox11b expression to promote proliferation and neurogenic determination of endogenous neural stem cells after injury may be a promising strategy in restorative therapy after spinal cord injury in mammals. ..
  32. Ramachandran R, Fausett B, Goldman D. Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol. 2010;12:1101-7 pubmed publisher
    ..we demonstrate that let-7 represses expression of regeneration-associated genes such as, ascl1a, hspd1, lin-28, oct4, pax6b and c-myc...
  33. Edel M, Boue S, Menchon C, Sánchez Danés A, Izpisua Belmonte J. Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. Cell Cycle. 2010;9:3414-22 pubmed
    ..We propose a model in which Rem2 GTPase is a key regulator maintaining pluripotency during early stages of embryogenesis and survival of neurons during later embryonic development. ..
  34. Wang X, Ren J, Wang Z, Yao J, Fei J. NRSF/REST is required for gastrulation and neurogenesis during zebrafish development. Acta Biochim Biophys Sin (Shanghai). 2012;44:385-93 pubmed publisher
    ..Our results showed that REST (especially maternal supplied REST) was required for gastrulation and neurogenesis during zebrafish early embryogenesis. ..
  35. Khan A, Nakamoto A, Okamoto S, Tai M, Nakayama Y, Kobayashi K, et al. Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. Mech Dev. 2012;129:219-35 pubmed publisher
    Zebrafish pou2, which encodes a class V POU transcription factor considered to be an orthologue of mouse Oct-3/4, has been implicated by mutant analysis in dorsoventral (DV) patterning, gastrulation, and endoderm formation in early ..
  36. Ho S, Goh C, Gan J, Lee Y, Lam M, Hong N, et al. Derivation and long-term culture of an embryonic stem cell-like line from zebrafish blastomeres under feeder-free condition. Zebrafish. 2014;11:407-20 pubmed publisher
    ..In conclusion, ZES1 cells possess both in vitro and in vivo pluripotency characteristics, indicating that nonmammalian ES cells can be readily derived and maintained for a long term under feeder-free culture conditions. ..
  37. Barresi M, Burton S, Dipietrantonio K, Amsterdam A, Hopkins N, Karlstrom R. Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn. 2010;239:2603-18 pubmed publisher
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS. ..
  38. Christen B, Robles V, Raya M, Paramonov I, Izpisua Belmonte J. Regeneration and reprogramming compared. BMC Biol. 2010;8:5 pubmed publisher
    ..We found that some of the pluripotency associated factors (oct4/pou5f1, sox2, c-myc, klf4, tert, sall4, zic3, dppa2/4 and fut1, a homologue of ssea1) were expressed before and during ..
  39. Dong X, Li J, He L, Gu C, Jia W, Yue Y, et al. Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes. J Biol Chem. 2017;292:13045-13055 pubmed publisher
    ..Further analyses reveal that diminishing znfl1s produces the decreased expressions of pou5f3, whereas overexpression of pou5f3 effectively rescues the reduced expression of hoxb1b in the ..
  40. Khan A, Nakamoto A, Tai M, Saito S, Nakayama Y, Kawamura A, et al. Mesendoderm specification depends on the function of Pou2, the class V POU-type transcription factor, during zebrafish embryogenesis. Dev Growth Differ. 2012;54:686-701 pubmed publisher
    Zebrafish pou2, encoding the class V POU transcription factor orthologous to mouse Oct-3/4, has been implicated in different aspects of development, such as dorsoventral patterning, endoderm formation, and brain regionalization, by ..
  41. Aanes H, Østrup O, Andersen I, Moen L, Mathavan S, Collas P, et al. Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. BMC Genomics. 2013;14:331 pubmed publisher
    ..New isoforms are identified even for well-characterized genes such as pou5f1, sall4 and dnmt1...
  42. Parvin M, Okuyama N, Inoue F, Islam M, Kawakami A, Takeda H, et al. Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain. Dev Dyn. 2008;237:1373-88 pubmed publisher
    Zebrafish pou5f1, also known as pou2, encodes a POU-family transcription factor that is transiently expressed in the prospective midbrain and anterior hindbrain during gastrulation, governing brain development...
  43. Robles V, Marti M, Izpisua Belmonte J. Study of pluripotency markers in zebrafish embryos and transient embryonic stem cell cultures. Zebrafish. 2011;8:57-63 pubmed publisher
    ..We consider this study a step forward in the knowledge of zebrafish pluripotency markers and, therefore, an important tool for the monitoring of zebrafish embryonic cell cultures. ..
  44. Marandel L, Labbe C, Bobe J, Jammes H, Lareyre J, Le Bail P. Do not put all teleosts in one net: focus on the sox2 and pou2 genes. Comp Biochem Physiol B Biochem Mol Biol. 2013;164:69-79 pubmed publisher
    The Pou2 and Sox2 proteins are major transcription factors for development and cell differentiation...
  45. Ma J, Evrard S, Badiola I, Siegfried G, Khatib A. Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). Eur J Cell Biol. 2017;96:457-468 pubmed publisher
    ..maintained the formation of immature regenerating vasculature that was associated with amplified expression of OCT4 and various angiogenic factors reported to be PC substrates and/or downstream effectors...
  46. Lindeman L, Reiner A, Mathavan S, Alestrom P, Collas P. Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. PLoS ONE. 2010;5:e15651 pubmed publisher
    ..We have designed and validated for the scientific community a comprehensive high-resolution tiling microarray for investigations of epigenetic states in zebrafish, a widely used developmental and disease model organism. ..
  47. Andersen I, Reiner A, Aanes H, Alestrom P, Collas P. Developmental features of DNA methylation during activation of the embryonic zebrafish genome. Genome Biol. 2012;13:R65 pubmed publisher
  48. Frankenberg S, Pask A, Renfree M. The evolution of class V POU domain transcription factors in vertebrates and their characterisation in a marsupial. Dev Biol. 2010;337:162-70 pubmed publisher
    b>POU5F1 (OCT4) encodes a master regulator of pluripotency that is present in all mammals. A paralogue, POU2, is also present in the genomes of marsupials and monotremes and is an orthologue of zebrafish pou2 and chicken POUV...
  49. Xiaohuan H, Yang Z, Linyan L, Zhenhua F, Linyan Z, Zhijian W, et al. Characterization of the POU5F1 Homologue in Nile Tilapia: From Expression Pattern to Biological Activity. Stem Cells Dev. 2016;25:1386-95 pubmed publisher
    ..However, the homologues of POU5F1 in teleost fish, including zebrafish and medaka, now named Pou5f3, exhibit considerable differences in expression pattern and pluripotency-maintaining activity...
  50. Wiellette E, Grinblat Y, Austen M, Hirsinger E, Amsterdam A, Walker C, et al. Combined haploid and insertional mutation screen in the zebrafish. Genesis. 2004;40:231-40 pubmed
    ..screen that identified five genes required for brain development, including novel alleles of nagie oko, pou5f1, ribosomal protein L36, and n-cadherin, as well as a novel allele of the laminin g1 gene that is required for ..
  51. Gill J, Lowe L, Nguyen J, Liu P, Blake T, Venkatesh B, et al. Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish. Zebrafish. 2010;7:333-41 pubmed publisher
    ..In addition, enforced expression of the zebrafish stem cell leukemia (scl) gene in the zebrafish testes also generated TGCTs in transgenic fish. These results demonstrate the feasibility of studying TGCTs in a model organism. ..
  52. Chen X, Xu B, Han X, Mao Z, Chen M, Du G, et al. The effects of triclosan on pluripotency factors and development of mouse embryonic stem cells and zebrafish. Arch Toxicol. 2015;89:635-46 pubmed publisher
    ..Although the expression levels of Sox2 mRNA were not changed, the mRNA levels of Oct4 and Nanog in TCS-treated groups were significantly decreased compared to controls...
  53. Liu R, Li M, Li Z, Hong N, Xu H, Hong Y. Medaka Oct4 is essential for pluripotency in blastula formation and ES cell derivation. Stem Cell Rev. 2015;11:11-23 pubmed publisher
    ..The transcription factor Oct4 or Pou5f1 identified in mouse features pluripotency expression and activity in the inner cell mass and embryonic stem (ES) ..
  54. Muto A, Calof A, Lander A, Schilling T. Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 2011;9:e1001181 pubmed publisher
  55. Lippok B, Song S, Driever W. Pou5f1 protein expression and posttranslational modification during early zebrafish development. Dev Dyn. 2014;243:468-77 pubmed publisher
    b>Pou5f1/Oct4 is a transcription factor essential for maintenance of pluripotency in mammals and for control of blastula and gastrula stage gene regulatory networks in zebrafish...
  56. Hauptmann G, Belting H, Wolke U, Lunde K, Söll I, Abdelilah Seyfried S, et al. spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development. 2002;129:1645-55 pubmed
    ..We show that spiel ohne grenzen (spg) zebrafish mutants develop rhombomeric territories that are abnormal in both size and shape...
  57. Gioacchini G, Giorgini E, Merrifield D, Hardiman G, Borini A, Vaccari L, et al. Probiotics can induce follicle maturational competence: the Danio rerio case. Biol Reprod. 2012;86:65 pubmed publisher
    ..expression, which have recently emerged as key regulators of oocyte acquisition of maturational competence, and pou5f1 gene expression, which in other models has been shown to govern the establishment of developmental competence of ..
  58. Schier A, Neuhauss S, Harvey M, Malicki J, Solnica Krezel L, Stainier D, et al. Mutations affecting the development of the embryonic zebrafish brain. Development. 1996;123:165-78 pubmed
    ..The identified loci establish the genetic foundation for a further analysis of the development of the zebrafish embryonic brain. ..
  59. Kurian L, Aguirre A, Sancho Martinez I, Benner C, Hishida T, Nguyen T, et al. Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. Circulation. 2015;131:1278-1290 pubmed publisher
  60. Johnstone T, Bazzini A, Giraldez A. Upstream ORFs are prevalent translational repressors in vertebrates. EMBO J. 2016;35:706-23 pubmed publisher
    ..These results provide insight into the regulatory code within mRNA leader sequences and their capacity to modulate translation across vertebrates. ..
  61. Rodr guez Mar A, Ca estro C, Bremiller R, Catchen J, Yan Y, Postlethwait J. Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS ONE. 2013;8:e73951 pubmed publisher
    ..Co-expression of cyp26a1 and the pluripotent germ cell stem cell marker pou5f1(oct4) in meiotically arrested oocytes was consistent with roles in mouse to promote germ cell survival and to ..