Gene Symbol: pou4f2
Description: POU class 4 homeobox 2
Alias: brn-3b, brn3.2, POU domain, class 4, transcription factor 2, brn3b, pou4f2/brn-3b
Rohrschneider M, Elsen G, Prince V. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007;309:358-72 pubmed
..Using morpholino knock-down and cell transplantation, we demonstrate that the Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity. ..
Sherpa T, Fimbel S, Mallory D, Maaswinkel H, Spritzer S, Sand J, et al
. Ganglion cell regeneration following whole-retina destruction in zebrafish. Dev Neurobiol. 2008;68:166-81 pubmed
..This model system for whole-retina regeneration has provided an informative view of the regenerative process. ..
Coutinho P, Pavlou S, Bhatia S, Chalmers K, Kleinjan D, van Heyningen V. Discovery and assessment of conserved Pax6 target genes and enhancers. Genome Res. 2011;21:1349-59 pubmed publisher
..We have identified several novel direct targets, including some putative disease genes, among them Foxp2; these will allow further dissection of Pax6 function in development and disease. ..
Yeh C, Kao S, Cheng Y, Hsu L. Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression. J Biol Chem. 2013;288:27927-39 pubmed publisher
..Our findings provide the first functional characterization of cdk10 in vertebrate development and reveal its critical function in neurogenesis by modulation of raf1a expression. ..
Mullally M, Albrecht C, Horton M, Laboissonniere L, Goetz J, Chowdhury R, et al
. Expression Profiling of Developing Zebrafish Retinal Cells. Zebrafish. 2016;13:272-80 pubmed publisher
..Further analysis of these profiles will reveal genes that can be mutated using genome editing techniques. Together these studies increase our knowledge of the genes driving development of different cell types in the zebrafish retina. ..
Maskell L, Qamar K, Babakr A, Hawkins T, Heads R, Budhram Mahadeo V. Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell Death Dis. 2017;8:e2861 pubmed publisher
..Here, we report that transcription factors (TFs) Brn-3a (POU4F1) and Brn-3b (POU4F2) are important for normal cardiac development...
deCarvalho A, Cappendijk S, Fadool J. Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish. Dev Dyn. 2004;229:869-76 pubmed
..In mouse, Brn-3b (Pou4f2, Brn3.2) and Brn-3c (Pou4f3, Brn3...
Xiao T, Roeser T, Staub W, Baier H. A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection. Development. 2005;132:2955-67 pubmed
..The mutated genes are predicted to encode molecules essential for building the intricate neural architecture of the visual system. ..
Matsuda N, Mishina M. Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant. Development. 2004;131:1913-25 pubmed
..The expression patterns of transcription factor genes ath5 and brn3b that are essential for the development and maintenance of RGCs were indistinguishable between wild-type and ntn ..