pou4f1

Summary

Gene Symbol: pou4f1
Description: POU class 4 homeobox 1
Alias: brn3.0, brn3a, POU domain, class 4, transcription factor 1, brain-specific homeobox/POU domain protein 3a, brn3b, etID22526.1
Species: zebrafish
Products:     pou4f1

Top Publications

  1. Sato T, Hamaoka T, Aizawa H, Hosoya T, Okamoto H. Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish. J Neurosci. 2007;27:5271-9 pubmed
    ..The retinotectal and the tectobulbar projections were visualized in a zebrafish stable transgenic line Tg(brn3a-hsp70:GFP)...
  2. Regan J, Concha M, Roussigne M, Russell C, Wilson S. An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry. Neuron. 2009;61:27-34 pubmed publisher
    ..The combined action of Fgf and Nodal signals ensures the establishment of neuroanatomical asymmetries with consistent laterality. ..
  3. Roussigné M, Bianco I, Wilson S, Blader P. Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei. Development. 2009;136:1549-57 pubmed publisher
    ..Our results provide evidence of a direct requirement for unilateral Nodal activity in establishing an asymmetry per se, rather than solely in biasing its laterality. ..
  4. Aizawa H, Bianco I, Hamaoka T, Miyashita T, Uemura O, Concha M, et al. Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus. Curr Biol. 2005;15:238-43 pubmed
  5. Aizawa H, Goto M, Sato T, Okamoto H. Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Dev Cell. 2007;12:87-98 pubmed
    ..Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei. ..
  6. Matsuda N, Mishina M. Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant. Development. 2004;131:1913-25 pubmed
    ..The expression patterns of transcription factor genes ath5 and brn3b that are essential for the development and maintenance of RGCs were indistinguishable between wild-type and ntn ..
  7. Bae Y, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y, et al. Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol. 2009;330:406-26 pubmed publisher
    ..Our data provide a platform for future studies of zebrafish cerebellar development. ..
  8. Colombo A, Palma K, Armijo L, Mione M, Signore I, Morales C, et al. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development. 2013;140:3997-4007 pubmed publisher
    ..Our results indicate that Daam1a plays a key role in asymmetric habenular morphogenesis mediating the growth of dendritic and axonal processes in dorsal habenular neurons. ..
  9. Dyer C, Linker C, Graham A, Knight R. Specification of sensory neurons occurs through diverse developmental programs functioning in the brain and spinal cord. Dev Dyn. 2014;243:1429-39 pubmed publisher
    ..Our work reveals fundamental differences between the development of MTN and RB neurons and suggests that these populations are non-homologous and thus have distinct developmental and, probably, evolutionary origins. ..

More Information

Publications16

  1. Maskell L, Qamar K, Babakr A, Hawkins T, Heads R, Budhram Mahadeo V. Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell Death Dis. 2017;8:e2861 pubmed publisher
    ..Here, we report that transcription factors (TFs) Brn-3a (POU4F1) and Brn-3b (POU4F2) are important for normal cardiac development...
  2. Amo R, Aizawa H, Takahoko M, Kobayashi M, Takahashi R, Aoki T, et al. Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. J Neurosci. 2010;30:1566-74 pubmed publisher
    ..These findings indicated that the lateral habenular pathways are evolutionarily conserved pathways and might control adaptive behaviors in vertebrates through the regulation of monoaminergic activities...
  3. Coolen M, Thieffry D, Drivenes Ø, Becker T, Bally Cuif L. miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors. Dev Cell. 2012;22:1052-64 pubmed publisher
  4. Dyer C, Blanc E, Hanisch A, Roehl H, Otto G, Yu T, et al. A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain. Development. 2014;141:63-72 pubmed publisher
    ..This controls a dynamic, posteriorly retracting expression of her5 that directs neuronal differentiation in a precise spatiotemporal manner in the midbrain...
  5. Garric L, Ronsin B, Roussigne M, Booton S, Gamse J, Dufourcq P, et al. Pitx2c ensures habenular asymmetry by restricting parapineal cell number. Development. 2014;141:1572-9 pubmed publisher
    ..We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry. ..
  6. Chou M, Amo R, Kinoshita M, Cherng B, Shimazaki H, Agetsuma M, et al. Social conflict resolution regulated by two dorsal habenular subregions in zebrafish. Science. 2016;352:87-90 pubmed publisher
    ..These results demonstrate that the dHbL and dHbM comprise a dual control system for conflict resolution of social aggression. ..
  7. Halluin C, Madelaine R, Naye F, Peers B, Roussigne M, Blader P. Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade. PLoS ONE. 2016;11:e0158210 pubmed publisher
    ..Our data sheds light on the mechanism underlying habenular development that may provide insights into how Nodal signalling imposes asymmetry on the timing of habenular neurogenesis. ..