Gene Symbol: pou3f3b
Description: POU class 3 homeobox 3b
Alias: pou1, pou23, wu:fb92g06, zfpou1, zp23, zp23pou, POU domain, class 3, transcription factor 3-B, POU domain gene 1, POU domain gene 23, POU domain protein 1, POU domain protein 23, ZP-23, brain-1.0, brain-specific homeobox/POU domain protein 1.0, fb92g06, zfbrn-1.0
Species: zebrafish
Products:     pou3f3b

Top Publications

  1. Kwak S, Phillips B, Heck R, Riley B. An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in mis-patterning of the otic vesicle. Development. 2002;129:5279-87 pubmed
    ..in expanded domains that include the entire otic epithelium juxtaposed to the hindbrain, and the posterior marker zp23 is not expressed...
  2. Vemaraju S, Kantarci H, Padanad M, Riley B. A spatial and temporal gradient of Fgf differentially regulates distinct stages of neural development in the zebrafish inner ear. PLoS Genet. 2012;8:e1003068 pubmed publisher
    ..Thus Fgf signaling renders SAG development self-regulating, ensuring steady production of an appropriate number of neurons as the larva grows...
  3. Spaniol P, Bornmann C, Hauptmann G, Gerster T. Class III POU genes of zebrafish are predominantly expressed in the central nervous system. Nucleic Acids Res. 1996;24:4874-81 pubmed
    ..Analysis of the expression of the class III genes shows that they are predominantly expressed in the central nervous system and that they may play important roles in patterning the embryonic brain. ..
  4. Kwak S, Vemaraju S, Moorman S, Zeddies D, Popper A, Riley B. Zebrafish pax5 regulates development of the utricular macula and vestibular function. Dev Dyn. 2006;235:3026-38 pubmed
    ..Thus, pax5 works in conjunction with fgf3 and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function...
  5. Sampath K, Stuart G. Developmental expression of class III and IV POU domain genes in the zebrafish. Biochem Biophys Res Commun. 1996;219:565-71 pubmed
    ..Since two of the POU PCR clones were obtained from genomic DNA, the fish genes may also be similar to their mammalian homologs in being largely devoid of introns. ..
  6. Hauptmann G, Gerster T. Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches. Dev Dyn. 2000;218:345-58 pubmed
    ..We propose that coordinate expression of particular combinations of class III POU genes contribute to pattern formation or cell fate determination in the developing CNS and other structures. ..
  7. Sakata S, Yan Y, Satou Y, Momoi A, Ngo Hazelett P, Nozaki M, et al. Conserved function of caspase-8 in apoptosis during bony fish evolution. Gene. 2007;396:134-48 pubmed
  8. Petit D, Mir A, Petit J, Thisse C, Delannoy P, Oriol R, et al. Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. J Biol Chem. 2010;285:38399-414 pubmed publisher
  9. Sweet E, Vemaraju S, Riley B. Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear. Dev Biol. 2011;358:113-21 pubmed publisher
    ..Thus, expression of fgf3, fgf8 or sox2 strongly enhances competence to respond to Atoh1. ..

More Information


  1. Kantarci H, Edlund R, Groves A, Riley B. Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling. PLoS Genet. 2015;11:e1005037 pubmed publisher
    ..Together, these data support a model in which Tfap2a, acting through Bmp7a, modulates Fgf and Notch signaling to control the duration, amount and speed of SAG neural development. ..
  2. Maulding K, Padanad M, Dong J, Riley B. Mesodermal Fgf10b cooperates with other fibroblast growth factors during induction of otic and epibranchial placodes in zebrafish. Dev Dyn. 2014;243:1275-85 pubmed publisher
    ..fgf10b participates in a late phase of otic induction and, in combination with fgf3, is especially critical for epibranchial induction. ..