Gene Symbol: pnp4a
Description: purine nucleoside phosphorylase 4a
Alias: zK76P14.1, zgc:86889, purine nucleoside phosphorylase 4a
Species: zebrafish

Top Publications

  1. Curran K, Lister J, Kunkel G, Prendergast A, Parichy D, Raible D. Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Dev Biol. 2010;344:107-18 pubmed publisher
    ..Foxd3 co-localized with pnp4a, a novel marker of early iridophore development, and was necessary for its expression...
  2. Lang M, Patterson L, Gordon T, Johnson S, Parichy D. Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genet. 2009;5:e1000744 pubmed publisher
    ..These findings identify bnc2 as an important mediator of adult pigment pattern formation and identify bonaparte mutants as an animal model for dissecting bnc2 functions...
  3. Patterson L, Parichy D. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genet. 2013;9:e1003561 pubmed publisher
  4. Eom D, Parichy D. A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Science. 2017;355:1317-1320 pubmed publisher
    ..These findings identify a role for macrophages in relaying long-range signals between nonimmune cells. This signaling modality may function in the remodeling and homeostasis of other tissues during normal development and disease. ..
  5. Krauss J, Astrinidis P, Astrinides P, Frohnhöfer H, Walderich B, NUSSLEIN VOLHARD C. transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival. Biol Open. 2013;2:703-10 pubmed publisher
    ..The specificity of the tra phenotype is most likely due to redundancy after gene multiplication, making this mutant a valuable model to understand the molecular function of Mpv17 in mitochondria. ..
  6. Patterson L, Bain E, Parichy D. Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. Nat Commun. 2014;5:5299 pubmed publisher
    ..Our results identify novel mechanisms of pattern development and illustrate how pattern diversity can be generated when a core network of pigment-cell autonomous interactions is coupled with changes in pigment cell differentiation. ..
  7. Tallafuss A, Kelly M, Gay L, Gibson D, Batzel P, Karfilis K, et al. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 2015;16:1100 pubmed publisher
    ..This important insight and the lists of enriched genes we have identified will now help pave the way to a better understanding of the mechanisms of embryonic and adult neuronal differentiation and how to manipulate these processes. ..
  8. Kimura T, Takehana Y, Naruse K. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. G3 (Bethesda). 2017;7:1357-1363 pubmed publisher
    ..gene of gu using synteny analysis with the zebrafish genome and found a strong candidate, purine nucleoside phosphorylase 4a (pnp4a)...
  9. Cechmanek P, McFarlane S. Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms. Dev Dyn. 2017;246:598-609 pubmed publisher
    ..RPE development to produce the monolayer epithelium that covers the back of the neural retina occurs in two distinct phases driven by distinct mechanisms. Developmental Dynamics 246:598-609, 2017. © 2017 Wiley Periodicals, Inc. ..

More Information


  1. Clancey L, Beirl A, Linbo T, Cooper C. Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish. PLoS ONE. 2013;8:e65096 pubmed publisher
    ..Taken together, these data suggest that vps11 promotes normal melanophore morphology and survival by inhibiting cathepsin release and/or activity. ..
  2. Krauss J, Frohnhöfer H, Walderich B, Maischein H, Weiler C, Irion U, et al. Endothelin signalling in iridophore development and stripe pattern formation of zebrafish. Biol Open. 2014;3:503-9 pubmed publisher
    ..In mammals the pathway is required for melanocyte development; therefore, our results indicate a previously unrecognized close evolutionary relationship between iridophores in zebrafish and melanocytes in mammals. ..
  3. Santos M, Braasch I, Boileau N, Meyer B, Sauteur L, Böhne A, et al. The evolution of cichlid fish egg-spots is linked with a cis-regulatory change. Nat Commun. 2014;5:5149 pubmed publisher