Gene Symbol: pmela
Description: premelanosome protein a
Alias: cb397, fdv, pmel17, sb:cb397, silva, wu:fc11g11, wu:fj24g11, zgc:136622, melanocyte protein PMEL, fading vision, melanosomal matrix protein, silver homolog a
Species: zebrafish

Top Publications

  1. Kelsh R, Brand M, Jiang Y, Heisenberg C, Lin S, Haffter P, et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123:369-89 pubmed
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  2. Schonthaler H, Lampert J, von Lintig J, Schwarz H, Geisler R, Neuhauss S. A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision. Dev Biol. 2005;284:421-36 pubmed
    ..The zebrafish mutant fading vision (fdv) has been identified in such a screen due to defects in vision accompanied by hypopigmentation in the ..
  3. Neuhauss S, Biehlmaier O, Seeliger M, Das T, Kohler K, Harris W, et al. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci. 1999;19:8603-15 pubmed
    ..The mutations uncovered by our behavioral assays provide distinct entry points for the study of visual pathways and set the stage for a genetic dissection of vertebrate vision. ..
  4. McGlinchey R, Shewmaker F, Hu K, McPhie P, Tycko R, Wickner R. Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH. J Biol Chem. 2011;286:8385-93 pubmed publisher
    Most amyloids are pathological, but fragments of Pmel17 form a functional amyloid in vertebrate melanosomes essential for melanin synthesis and deposition. We previously reported that only at the mildly acidic pH (4-5...
  5. Greenhill E, Rocco A, Vibert L, Nikaido M, Kelsh R. An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. PLoS Genet. 2011;7:e1002265 pubmed publisher
    ..More generally, this novel approach to understanding melanocyte differentiation provides a basis for systematic modelling of differentiation in this and other cell-types. ..
  6. Burgoyne T, O Connor M, Seabra M, Cutler D, Futter C. Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL. J Cell Sci. 2015;128:1400-7 pubmed publisher
    ..Taken together, our findings indicate that melanosome number and shape are independently regulated and that melanosome shape controls a function in the RPE that depends on localisation in the apical processes. ..
  7. Eom D, Bain E, Patterson L, Grout M, Parichy D. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. elife. 2015;4: pubmed publisher
    ..Our study reveals a novel mechanism of cellular communication, roles for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a striking difference in adult form. ..
  8. Seberg H, Van Otterloo E, Loftus S, Liu H, Bonde G, Sompallae R, et al. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017;13:e1006636 pubmed publisher
    ..In addition, they suggest that TFAP2A activity, like MITF activity, has the potential to modulate the phenotype of melanoma cells. ..
  9. Heisenberg C, Brand M, Jiang Y, Warga R, Beuchle D, van Eeden F, et al. Genes involved in forebrain development in the zebrafish, Danio rerio. Development. 1996;123:191-203 pubmed
    ..In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses. ..

More Information


  1. Cechmanek P, McFarlane S. Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms. Dev Dyn. 2017;246:598-609 pubmed publisher
    ..RPE development to produce the monolayer epithelium that covers the back of the neural retina occurs in two distinct phases driven by distinct mechanisms. Developmental Dynamics 246:598-609, 2017. © 2017 Wiley Periodicals, Inc. ..