pmaip1

Summary

Gene Symbol: pmaip1
Description: phorbol-12-myristate-13-acetate-induced protein 1
Alias: zgc:162379, phorbol-12-myristate-13-acetate-induced protein 1, Noxa
Species: zebrafish

Top Publications

  1. Parant J, George S, Holden J, Yost H. Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech. 2010;3:45-56 pubmed publisher
  2. Jette C, Flanagan A, Ryan J, Pyati U, Carbonneau S, Stewart R, et al. BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals. Cell Death Differ. 2008;15:1063-72 pubmed publisher
  3. Choi J, Kim S, Ahn J, Youn P, Kang J, Park K, et al. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish. Aquat Toxicol. 2010;100:151-9 pubmed publisher
    ..In addition, the p53-related pro-apoptotic genes Bax, Noxa, and p21 were upregulated after treatment with AgNPs...
  4. Kratz E, Eimon P, Mukhyala K, Stern H, Zha J, Strasser A, et al. Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ. 2006;13:1631-40 pubmed
    ..These data indicate substantial functional similarity between zebrafish and mammalian Bcl-2 family members, and establish the zebrafish as a relevant model for studying the intrinsic apoptosis pathway. ..
  5. Hochgreb Hägele T, Koo D, Bronner M. Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial bone formation. Dev Biol. 2015;400:23-32 pubmed publisher
    ..Taken together, the results suggest that Znf385C acts as a developmental switch for p53 function that modulates cell cycle arrest of chondrocytes and regulates timing of jaw cartilage maturation and ossification. ..
  6. Sorrells S, Toruno C, Stewart R, Jette C. Analysis of apoptosis in zebrafish embryos by whole-mount immunofluorescence to detect activated Caspase 3. J Vis Exp. 2013;:e51060 pubmed publisher
    ..Overall, the Casp3 assay represents a robust, highly reproducible assay in which to analyze apoptotic cells in early zebrafish embryos. ..
  7. de Peralta M, Mouguelar V, Sdrigotti M, Ishiy F, Fanganiello R, Passos Bueno M, et al. Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes. Cell Death Dis. 2016;7:e2397 pubmed publisher
    ..Based on this, we suggest CNBP as an additional target for new alternative therapeutic treatments to reduce craniofacial defects not only in TCS but also in other neurocristopathies. ..
  8. Suzuki N, Hanmoto T, Yano S, Furusawa Y, Ikegame M, Tabuchi Y, et al. Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound. Comp Biochem Physiol A Mol Integr Physiol. 2016;195:26-31 pubmed publisher
    ..Thus, we are the first to demonstrate that LIPUS directly functions to osteoclasts and to conclude that LIPUS directly causes apoptosis in osteoclasts shortly after exposure. ..
  9. Chen M, Hsu L, Wu J, Yeh C, Tsai J, Hseu Y, et al. Exposure to benzidine caused apoptosis and malformation of telencephalon region in zebrafish. Environ Toxicol. 2014;29:1428-36 pubmed publisher
    ..Real-time polymerase chain reaction analysis also showed that benzidine treatment affected p53, bax, and noxa expression...

More Information

Publications18

  1. Jeon H, Lee H. Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. FEBS J. 2013;280:1518-30 pubmed publisher
    ..The clinical implications of these results relate to the indication that Aurora-A inhibitors may be effective towards cancers with intact p53. ..
  2. Wang W, Hong J, Lin G, Liu W, Gong H, Lu M, et al. Stage-specific expression of TNF? regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells. PLoS ONE. 2011;6:e16740 pubmed publisher
    ..i.). Taken together, our results indicate that IPNV triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNF?, and these results may provide new insights into the pathogenesis of RNA viruses. ..
  3. Christen V, Capelle M, Fent K. Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish. Toxicol Appl Pharmacol. 2013;272:519-28 pubmed publisher
    ..1 and 5mg/L AgNPs. Furthermore, transcriptional alterations occurred in the pro-apoptotic genes Noxa and p21. The ER stress response was strong in ZFL cells and occurred in zebrafish embryos as well...
  4. Zhong J, Zhou L, Li Z, Wang Y, Gui J. Zebrafish Noxa promotes mitosis in early embryonic development and regulates apoptosis in subsequent embryogenesis. Cell Death Differ. 2014;21:1013-24 pubmed publisher
    b>Noxa functions in apoptosis and immune system of vertebrates, but its activities in embryo development remain unclear...
  5. Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
    ..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
  6. Costa S, Monteiro M, da Silva Júnior F, Sandrini J. Methylene blue toxicity in zebrafish cell line is dependent on light exposure. Cell Biol Int. 2016;40:895-905 pubmed publisher
    ..However, the pathways leading to apoptosis in this model appear to be dependent on the type of MB exposure (in the presence or absence of PAR). ..
  7. Chakraborty A, Uechi T, Higa S, Torihara H, Kenmochi N. Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response. PLoS ONE. 2009;4:e4152 pubmed publisher
    ..These results suggest that ribosomal dysfunction due to the loss of L11 activates a p53-dependent checkpoint response to prevent improper embryonic development. ..
  8. Christen V, Faltermann S, Brun N, Kunz P, Fent K. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos. Sci Total Environ. 2017;586:1204-1218 pubmed publisher
    ..Barquat and BAC let to induction of ER stress and inflammation in vitro, and BAC and glutaraldehyde at non-toxic concentrations in vivo, while benzalkonium chloride induced expression of tnf-? only. ..
  9. Boer E, Jette C, Stewart R. Neural Crest Migration and Survival Are Susceptible to Morpholino-Induced Artifacts. PLoS ONE. 2016;11:e0167278 pubmed publisher
    ..We suggest that comparison of genetic mutants between different species is the most rigorous method for identifying conserved genetic mechanisms controlling NC development and is critical to identify new treatments for NC diseases. ..