Gene Symbol: plxna3
Description: plexin A3
Alias: plexina3, plexin A3, set, sidetracked, vermicelli, vmc
Species: zebrafish

Top Publications

  1. Palaisa K, Granato M. Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance. Development. 2007;134:3251-7 pubmed
    ..In zebrafish sidetracked (set) mutants, motor axons exit from the spinal cord at ectopic positions...
  2. Ton Q, Kathryn Iovine M. Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration. Dev Biol. 2012;366:195-203 pubmed publisher
    ..Of these, nrp2a, plxna1, and plxna3 are expressed in the regenerating fin...
  3. Feldner J, Reimer M, Schweitzer J, Wendik B, Meyer D, Becker T, et al. PlexinA3 restricts spinal exit points and branching of trunk motor nerves in embryonic zebrafish. J Neurosci. 2007;27:4978-83 pubmed
    ..Plexins are receptor components for semaphorins that influence motor axon growth and path finding. We cloned plexinA3 in zebrafish and localized plexinA3 mRNA in primary motor neurons during axon outgrowth...
  4. Tanaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, et al. Novel mutations affecting axon guidance in zebrafish and a role for plexin signalling in the guidance of trigeminal and facial nerve axons. Development. 2007;134:3259-69 pubmed
    ..Time-lapse observations of the class 1 mutant, vermicelli (vmc), which has a defect in the plexin A3 (plxna3) gene, revealed that Plxna3 acts with its ligand Sema3a1 for ..
  5. Kimura M, Taniguchi M, Mikami Y, Masuda T, Yoshida T, Mishina M, et al. Identification and characterization of zebrafish semaphorin 6D. Biochem Biophys Res Commun. 2007;363:762-8 pubmed
    ..It induces the repulsion of dorsal root ganglion axons, but not sympathetic axons. Consequently, Sema6D might use Plexin-A1 as a receptor to repel specific types of axons during development. ..
  6. Hilario J, Rodino Klapac L, Wang C, Beattie C. Semaphorin 5A is a bifunctional axon guidance cue for axial motoneurons in vivo. Dev Biol. 2009;326:190-200 pubmed publisher
    ..The TSR domain promotes growth of developing motor axons into the ventral myotome whereas the sema domain mediates repulsion and keeps these motor axons from branching into surrounding myotome regions. ..
  7. Sainath R, Granato M. Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish. PLoS ONE. 2013;8:e54071 pubmed publisher
    ..Furthermore, we find that null mutants of the guidance receptor plexin A3 display identical motor axon branching defects, and time lapse analysis reveals that precocious branch formation ..
  8. Barton R, Khakbaz P, Bera I, Klauda J, Iovine M, Berger B. Interplay of Specific Trans- and Juxtamembrane Interfaces in Plexin A3 Dimerization and Signal Transduction. Biochemistry. 2016;55:4928-38 pubmed publisher
    ..experimental and simulation approach, we find disruption of the small-x3-small motifs in the Danio rerio Plexin A3 TM domain enhances dimerization of the TM-JM domain by enhancing JM-mediated dimerization...
  9. Liu C, Ma W, Su W, Zhang J. Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development. 2012;139:4591-600 pubmed publisher
    ..Furthermore, overexpression of islet2 in slg mutant embryos rescued the shortened CaP axon phenotypes. Together, these data reveal that prdm14 regulates CaP axon outgrowth through activation of islet2 expression. ..

More Information


  1. Plazas P, Nicol X, Spitzer N. Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3. Proc Natl Acad Sci U S A. 2013;110:1524-9 pubmed publisher
    ..This competition was not mediated by synaptic transmission. Combination of PlexinA3 knockdown with suppression of Ca(2+) activity in single PMN produced a synergistic increase in the incidence of ..
  2. Yoo S, Pascoe H, Pereira T, Kondo S, Jacinto A, Zhang X, et al. Plexins function in epithelial repair in both Drosophila and zebrafish. Nat Commun. 2016;7:12282 pubmed publisher
    ..We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa. ..
  3. Taniguchi M, Masuda T, Mikami Y, Kimura M, Yoshida T, Mishina M, et al. Identification and characterization of a novel zebrafish semaphorin. Neurosci Lett. 2011;488:215-20 pubmed publisher
    ..Sema6E chemorepels not only dorsal root ganglion axons but also sympathetic axons. Therefore, Sema6E might utilize Plexin-A1 as a receptor to repel axons of the specific types during development. ..
  4. Barton R, Palacio D, Iovine M, Berger B. A cytosolic juxtamembrane interface modulates plexin A3 oligomerization and signal transduction. PLoS ONE. 2015;10:e0116368 pubmed publisher
    ..destabilizing mutations to PlxnA3 homodimerization (M1281F) are able to rescue motor patterning defects in sidetracked zebrafish embryos, whereas mutations that enhance PlxnA3 homodimerization (M1281L) are not...
  5. Hogl S, van Bebber F, Dislich B, Kuhn P, Haass C, Schmid B, et al. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 2013;13:1519-27 pubmed publisher
    ..Additionally, several candidate substrates with a function in neurite outgrowth and axon guidance, such as plexin A3 and glypican-1 were identified, pointing to a function of Bace1 in neurodevelopment...
  6. Pietri T, Roman A, Guyon N, Romano S, Washbourne P, Moens C, et al. The first mecp2-null zebrafish model shows altered motor behaviors. Front Neural Circuits. 2013;7:118 pubmed publisher
    ..They present nonetheless clear behavioral alterations during their early development, including spontaneous and sensory-evoked motor anomalies, as well as defective thigmotaxis...
  7. Joris M, Schloesser M, Baurain D, Hanikenne M, Muller M, Motte P. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Nucleic Acids Res. 2017;45:9547-9557 pubmed publisher
    ..Our data contribute to the debate about MO specificity, efficacy and the number of unknown targeted sequences. ..