Gene Symbol: pklr
Description: pyruvate kinase L/R
Alias: wu:fd15e01, wu:fi37e08, pyruvate kinase PKLR, pyruvate kinase, liver and RBC
Species: zebrafish

Top Publications

  1. Drew R, Rodnick K, Settles M, Wacyk J, Churchill E, Powell M, et al. Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio). Physiol Genomics. 2008;35:283-95 pubmed publisher
  2. Zhao F, Jiang G, Wei P, Wang H, Ru S. Bisphenol S exposure impairs glucose homeostasis in male zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2018;147:794-802 pubmed publisher
  3. Sharma M, Denovan Wright E, Boudreau M, Wright J. A cellular retinoic acid-binding protein from zebrafish (Danio rerio): cDNA sequence, phylogenetic analysis, mRNA expression, and gene linkage mapping. Gene. 2003;311:119-28 pubmed
    ..Based on phylogenetic analysis and the syntenic relationship to the CRABPII gene in human, the zebrafish cDNA clone appears to code for a type II CRABP. ..
  4. Liu L, Fox C, North T, Goessling W. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Dis Model Mech. 2013;6:1271-8 pubmed publisher
    ..Knockdown of three genes (pnpla3, pklr and mapk10) decreased expression of hepatic progenitor cells, whereas knockdown of eight genes (pnpla3, cpn1, trib1,..
  5. Li Z, Xu H, Zheng W, Lam S, Gong Z. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. PLoS ONE. 2013;8:e77292 pubmed publisher
    ..The expression profiles associated with TCDD could be useful for monitoring environmental dioxin and dioxin-like contamination. ..
  6. Chen L, Hu Y, He J, Chen J, Giesy J, Xie P. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Environ Sci Technol. 2017;51:596-607 pubmed publisher
    ..Identification of proteins and metabolites in liver of zebrafish responsive to MC-LR provides insights into mechanisms of chronic toxicity of MCs. ..
  7. Li Z, Zheng W, Li H, Li C, Gong Z. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS ONE. 2015;10:e0132319 pubmed publisher
    ..Collectively, our Myc/xmrk zebrafish model suggests synergetic effect of EGFR and MYC in triggering Warburg effect in the HCC formation and may provide a promising in vivo model for Warburg effect. ..
  8. Marques I, Leito J, Spaink H, Testerink J, Jaspers R, Witte F, et al. Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts. J Comp Physiol B. 2008;178:77-92 pubmed
    ..We have identified here many novel genes involved in the response to CCH in the heart, which may have potential clinical implications in the future. ..
  9. Lam S, Ung C, Hlaing M, Hu J, Li Z, Mathavan S, et al. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses. Biochim Biophys Acta. 2013;1830:4778-89 pubmed publisher
    ..This is the first transcriptomic report on 4-NP induced hepatotoxicity. ..

More Information


  1. Fang L, Liang X, Zhou Y, Guo X, He Y, Yi T, et al. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Br J Nutr. 2014;111:808-18 pubmed publisher
    ..In conclusion, the present study demonstrates that it is possible to permanently modify carbohydrate digestion, transport and metabolism of adult zebrafish through early nutritional programming. ..
  2. Driessen M, Kienhuis A, Vitins A, Pennings J, Pronk T, van den Brandhof E, et al. Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicol Lett. 2014;230:48-56 pubmed publisher
    ..This set included several cytochrome P450 genes (cyp2k19, cyp4v7, cyp2aa3), genes related to liver development (pklr) and genes important in oxidoreduction processes (zgc:163022, zgc:158614, zgc:101858 and sqrdl)...
  3. Michel M, Page McCaw P, Chen W, Cone R. Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proc Natl Acad Sci U S A. 2016;113:3084-9 pubmed publisher
  4. Jin C, Luo T, Zhu Z, Pan Z, Yang J, Wang W, et al. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2017;202:85-93 pubmed publisher
    ..These results indicated that exposure to IMZ could cause gut microbiota dysbiosis and metabolic disorders in adult zebrafish. ..
  5. Rudner L, Brown K, Dobrinski K, Bradley D, Garcia M, Smith A, et al. Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 2011;30:4289-96 pubmed publisher
    ..rerio T-ALL were also found in multiple human T-ALL cases. These results suggest that zebrafish and human T-ALLs are similar at the genomic level, and are governed by factors that have persisted throughout evolution. ..
  6. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). J Exp Biol. 2014;217:1139-49 pubmed publisher
    ..Overall, supplementation of egg yolk with high glucose levels had little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish. ..
  7. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Br J Nutr. 2015;113:403-13 pubmed publisher
    ..Globally, our data suggest that glucose stimulus at embryo stage has the potential to alter particular steps of glucose metabolism in zebrafish juveniles. ..