Gene Symbol: pkd2l1
Description: polycystic kidney disease 2-like 1
Alias: si:packtrz.2, si:xx-packtrz.2, polycystic kidney disease 2-like 1 protein
Djenoune L, Khabou H, Joubert F, Quan F, Nunes Figueiredo S, Bodineau L, et al
. Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Front Neuroanat. 2014;8:26 pubmed publisher
..b>PKD2L1, a transient receptor potential channel that could play a role as a sensory receptor, has been found in cells ..
Böhm U, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, et al
. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nat Commun. 2016;7:10866 pubmed publisher
..In mutants for the channel Pkd2l1, CSF-cNs lose their response to bending and animals show a selective reduction of tail beat frequency, confirming ..
Djenoune L, Desban L, Gomez J, Sternberg J, Prendergast A, Langui D, et al
. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Sci Rep. 2017;7:719 pubmed publisher
..In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord...
Ribeiro A, Monteiro J, Certal A, Cristovão A, Saude L. Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish. Open Biol. 2017;7: pubmed publisher
..These data establish Foxj1a as a pan-ependymal marker in development, homeostasis and regeneration and may help identify the signals that enable this progenitor population to replace lost cells after spinal cord injury. ..
Quan F, Dubessy C, Galant S, Kenigfest N, Djenoune L, Leprince J, et al
. Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PLoS ONE. 2015;10:e0119290 pubmed publisher
..These cells were also shown to be GABAergic and express the gene encoding the polycystic kidney disease 2-like 1 (pkd2l1) channel, indicating that they likely correspond to cerebrospinal fluid-contacting neurons...
Fidelin K, Djenoune L, Stokes C, Prendergast A, Gomez J, Baradel A, et al
. State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Curr Biol. 2015;25:3035-47 pubmed publisher
..Altogether, our results demonstrate how a spinal GABAergic sensory neuron can tune the excitability of locomotor CPGs in a state-dependent manner by projecting onto essential components of the excitatory premotor pool. ..