Gene Symbol: pink1
Description: PTEN induced putative kinase 1
Alias: wu:fc39e12, zgc:101729, serine/threonine-protein kinase PINK1, mitochondrial
Species: zebrafish

Top Publications

  1. Anichtchik O, Diekmann H, Fleming A, Roach A, Goldsmith P, Rubinsztein D. Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci. 2008;28:8199-207 pubmed publisher
    ..PTEN (phosphatase/tensin homolog on chromosome 10)-induced putative kinase 1 (PINK1), a putative kinase that is mutated in autosomal recessive forms of PD, is also implicated in sporadic cases of ..
  2. Xi Y, Ryan J, Noble S, Yu M, Yilbas A, Ekker M. Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function. Eur J Neurosci. 2010;31:623-33 pubmed publisher
    Mutations in the human PTEN-induced kinase 1 (PINK1) gene are linked to recessive familial Parkinson's disease. Animal models of altered PINK1 function vary greatly in their phenotypic characteristics...
  3. Sallinen V, Kolehmainen J, Priyadarshini M, Toleikyte G, Chen Y, Panula P. Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish. Neurobiol Dis. 2010;40:93-101 pubmed publisher
    The functions of PTEN (phosphatase/tensin homolog)-induced putative kinase (PINK1), which is mutated in early-onset Parkinson's disease, are poorly understood...
  4. Priyadarshini M, Tuimala J, Chen Y, Panula P. A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling. Neurobiol Dis. 2013;54:127-38 pubmed publisher
    The PTEN induced putative kinase 1 (PINK1) gene is mutated in patients with hereditary early onset Parkinson's disease (PD). The targets of PINK1 and the mechanisms in PD are still not fully understood...
  5. Hu Z, Chen B, Zhang J, Ma Y. Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease. J Biol Chem. 2017;292:18062-18074 pubmed publisher
    ..The ATG5 down-regulation led to the upgrade of PD-associated proteins, such as β-synuclein, Parkin, and PINK1, aggravation of MPTP-induced PD-mimicking pathological locomotor behavior, DA neuron loss labeled by tyrosine ..
  6. Matsui H, Sugie A. An optimized method for counting dopaminergic neurons in zebrafish. PLoS ONE. 2017;12:e0184363 pubmed publisher
    ..optimized protocol, we confirmed that administration of 6-hydroxydopamine (a neurotoxin) or the deletion of the PINK1 gene (one of the causative genes of familiar PD) in zebrafish caused significant reduction in the number of ..
  7. Feng C, Wen Z, Huang S, Hung H, Chen C, Yang S, et al. Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae. Zebrafish. 2014;11:227-39 pubmed publisher
    ..The present study also analyzed the mRNA expression of parkin, pink1, and cd-11b, because the expression of these molecular targets has been shown to result in attenuation in ..
  8. Petko J, Kabbani N, Frey C, Woll M, Hickey K, Craig M, et al. Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neurosci. 2009;10:27 pubmed publisher
    ..NCS-1, while morpholino-mediated knockdown experiments demonstrated an essential role for arf1, pi4kbeta, dan, and pink1 in semicircular canal formation...
  9. Gao D, Wu M, Wang C, Wang Y, Zuo Z. Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquat Toxicol. 2015;167:200-8 pubmed publisher
    ..This study provides clues that BaP may constitute an important environmental risk factor for neurodegenerative diseases in humans. ..

More Information


  1. Priyadarshini M, Orosco L, Panula P. Oxidative stress and regulation of Pink1 in zebrafish (Danio rerio). PLoS ONE. 2013;8:e81851 pubmed publisher
    ..Loss of function mutations in the PTEN-induced putative kinase (PINK1) gene cause autosomal recessive PD...
  2. Sarath Babu N, Murthy C, Kakara S, Sharma R, Brahmendra Swamy C, Idris M. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease in zebrafish. Proteomics. 2016;16:1407-20 pubmed publisher
    ..This zebrafish based PD model can be used as a potential model system for screening prospective drug molecules for PD. ..
  3. Kansler E, Verma A, Langdon E, Simon Vermot T, Yin A, Lee W, et al. Melanoma genome evolution across species. BMC Genomics. 2017;18:136 pubmed publisher
    ..resulted in a highly drug resistant tumor that showed 3 additional new DNA mutations in the genes BUB1B, PINK1, and COL16A1...
  4. Díaz Casado M, Lima E, Garcia J, Doerrier C, Aranda P, Sayed R, et al. Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network. J Pineal Res. 2016;61:96-107 pubmed publisher
    ..involve knockout or knockdown models to inhibit the expression of mitochondrial-related genes, including parkin, PINK1, and DJ-1 ones...
  5. Zhang Y, Nguyen D, Olzomer E, Poon G, Cole N, Puvanendran A, et al. Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell Chem Biol. 2017;24:471-480.e4 pubmed publisher
    ..on mTOR inhibition for activating autophagy, and instead may rely on the Parkinson's disease-associated proteins PINK1 and PARKIN to activate the autophagy-lysosomal pathway in response to mitochondrial damage...
  6. Noble S, Ismail A, Godoy R, Xi Y, Ekker M. Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival. J Neurochem. 2012;122:196-207 pubmed publisher
    ..Some of these genes, for example, Pink1 and Parkin, are part of a common pathway...
  7. Flinn L, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, et al. TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. Ann Neurol. 2013;74:837-47 pubmed publisher
    Loss of function mutations in PINK1 typically lead to early onset Parkinson disease (PD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study neurodegenerative diseases...
  8. Hu Z, Zhang J, Zhang Q. Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis. Autophagy. 2011;7:1514-27 pubmed
    ..2, pink1, ?-synuclein, xb51 and zic1...