Gene Symbol: pgk1
Description: phosphoglycerate kinase 1
Alias: wu:fd59b07, wu:fj36g06, zgc:56252, zgc:77899, phosphoglycerate kinase 1
Hagenaars A, Vergauwen L, Benoot D, Laukens K, Knapen D. Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity. Chemosphere. 2013;91:844-56 pubmed publisher
..Despite this increase in metabolic expenditure, no effects on reproduction were found indicating that the fish seemed to cope with exposure to the tested concentrations of PFOA during the exposure period of 1 month. ..
Karanth S, Zinkhan E, Hill J, Yost H, Schlegel A. FOXN3 Regulates Hepatic Glucose Utilization. Cell Rep. 2016;15:2745-55 pubmed publisher
..Human FOXN3 binds DNA sequences in the human MYC and zebrafish mycb loci. We conclude that the rs8004664 risk allele drives excessive expression of FOXN3 during fasting and that FOXN3 regulates fasting blood glucose. ..
Wu S, Storey J, Storey K. Phosphoglycerate kinase 1 expression responds to freezing, anoxia, and dehydration stresses in the freeze tolerant wood frog, Rana sylvatica. J Exp Zool A Ecol Genet Physiol. 2009;311:57-67 pubmed publisher
..made from brain of frozen frogs revealed freeze-responsive up-regulation of the glycolytic enzyme, phosphoglycerate kinase 1 (PGK1)...
Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
..of mRNA levels, strong hypoxia enhanced mRNA levels of the control genes (lactate dehydrogenase A and phosphoglycerate kinase 1). Surprisingly, levels of hemoglobin alpha and beta mRNA were significantly reduced under severe hypoxia...
Singh S, Saxena S, Meena Lakshmi M, Saxena P, Idris M. Proteome profile of zebrafish Danio rerio olfactory bulb based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 2011;8:183-9 pubmed publisher
..This study provides the D. rerio olfactory bulb two-dimensional gel electrophoresis proteome map and the details of 221 olfactory bulb-specific proteins. ..
Felber K, Elks P, Lecca M, Roehl H. Expression of osterix Is Regulated by FGF and Wnt/Î²-Catenin Signalling during Osteoblast Differentiation. PLoS ONE. 2015;10:e0144982 pubmed publisher
..Based upon these data, we propose that FGF and Wnt/Î²-Catenin pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation. ..
Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
Boyd P, Tu W, Shorrock H, Groen E, Carter R, Powis R, et al
. Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy. PLoS Genet. 2017;13:e1006744 pubmed publisher
..Moreover, targeting of a single bioenergetic protein, phosphoglycerate kinase 1 (Pgk1), was found to modulate motor neuron vulnerability in vivo...