Gene Symbol: pfkfb3
Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Alias: wu:fc31e01, zgc:73257, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6-phosphofructo-2-kinase, fructose-2,6-biphosphatase 3
Vettori A, Greenald D, Wilson G, Peron M, Facchinello N, Markham E, et al
. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1? stabilization. Proc Natl Acad Sci U S A. 2017;114:9948-9953 pubmed publisher
..Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL. ..
De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong B, Cantelmo A, et al
. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154:651-63 pubmed publisher
..glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation...
Xu T, Zhao J, Hu P, Dong Z, Li J, Zhang H, et al
. Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage. Toxicol Appl Pharmacol. 2014;277:183-91 pubmed publisher
..Taken together, our results demonstrated that PCP causes a Warburg-like effect on zebrafish embryos during gastrulation, and the affected embryos had the phenotype of developmental delay...
Marín Juez R, Marass M, Gauvrit S, Rossi A, Lai S, Materna S, et al
. Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2016;113:11237-11242 pubmed
..Our work also paves the way for future studies designed to understand the molecular mechanisms that regulate fast revascularization. ..
Gerri C, Marín Juez R, Marass M, Marks A, Maischein H, Stainier D. Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish. Nat Commun. 2017;8:15492 pubmed publisher
..Altogether, our data provide genetic evidence that Hif-1α regulates interactions between macrophages and endothelial cells starting with the mobilization of macrophages from the AGM. ..
Hurem S, Martín L, Brede D, Skjerve E, Nourizadeh Lillabadi R, Lind O, et al
. Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. PLoS ONE. 2017;12:e0179259 pubmed publisher
..The present findings show that continuous gamma irradiation (? 0.54 mGy/h) during early gastrula causes gene expression changes that are linked to developmental defects in zebrafish embryos. ..