Gene Symbol: pes
Description: pescadillo
Alias: pescadillo, etID309792.5
Species: zebrafish
Products:     pes

Top Publications

  1. Allende M, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N. Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Genes Dev. 1996;10:3141-55 pubmed
    ..The pescadillo (pes) gene is predicted to encode a protein of 582 amino acids with no recognizable functional motifs, which is ..
  2. Lerch Gaggl A, Haque J, Li J, Ning G, Traktman P, Duncan S. Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J Biol Chem. 2002;277:45347-55 pubmed
    Mutation of the zebrafish pescadillo gene blocks expansion of a number of tissues in the developing embryo, suggesting roles for its gene product in controlling cell proliferation...
  3. Lapik Y, Fernandes C, Lau L, Pestov D. Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol Cell. 2004;15:17-29 pubmed
    ..Here we develop a series of transposon-derived dominant mutants of Pes1, the mouse homolog of the zebrafish Pescadillo and yeast Nop7p implicated in ribosome biogenesis and cell proliferation control...
  4. Provost E, Wehner K, Zhong X, Ashar F, Nguyen E, Green R, et al. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development. 2012;139:3232-41 pubmed publisher
    ..Among these, ribosomal protein L3 (rpl3) and pescadillo (pes) were selected for additional analysis...
  5. Haque J, Boger S, Li J, Duncan S. The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics. 2000;70:201-10 pubmed
    b>Pescadillo was originally identified in the zebrafish Danio rerio as a site of a retrovirus-insertion mutation that caused severe defects during embryogenesis...
  6. Noël E, Casal Sueiro A, Busch Nentwich E, Verkade H, Dong P, Stemple D, et al. Organ-specific requirements for Hdac1 in liver and pancreas formation. Dev Biol. 2008;322:237-50 pubmed publisher
    ..These findings establish zebrafish as a tractable system to investigate chromatin remodelling factor functions in controlling gene expression programmes in vertebrate endodermal organogenesis. ..
  7. Barresi M, Burton S, Dipietrantonio K, Amsterdam A, Hopkins N, Karlstrom R. Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn. 2010;239:2603-18 pubmed publisher
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS. ..
  8. Ueda K, Xu Z, Miyagi N, Ono M, Wabiko H, Masuda K, et al. Isolation and characterization of a carrot nucleolar protein with structural and sequence similarity to the vertebrate PESCADILLO protein. Plant Sci. 2013;208:83-92 pubmed publisher
    ..Its deduced amino acid sequence showed about 40% identity with the PESCADILLO protein of zebrafish and humans...
  9. Joris M, Schloesser M, Baurain D, Hanikenne M, Muller M, Motte P. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Nucleic Acids Res. 2017;45:9547-9557 pubmed publisher
    ..Our data contribute to the debate about MO specificity, efficacy and the number of unknown targeted sequences. ..

More Information


  1. Poon K, Richardson M, Lam C, Khoo H, Korzh V. Expression pattern of neuronal nitric oxide synthase in embryonic zebrafish. Gene Expr Patterns. 2003;3:463-6 pubmed
  2. Simmons T, Appel B. Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS ONE. 2012;7:e32317 pubmed publisher
    ..We subsequently determined that vu166 is an allele of pescadillo, a gene known to play a role in ribosome biogenesis and cell proliferation...