Gene Symbol: pdk2b
Description: pyruvate dehydrogenase kinase, isozyme 2b
Alias: Pdk, pdk2, zgc:56209, pyruvate dehydrogenase kinase isozyme 2, mitochondrial, pyruvate dehydrogenase kinase, isoenzyme 2, pyruvate dehydrogenase kinase, isoenzyme 2b
De Felice B, Copia L, Guida M. Gene expression profiling in zebrafish embryos exposed to diclofenac, an environmental toxicant. Mol Biol Rep. 2012;39:2119-28 pubmed publisher
..Our results, for the first time, provide an insight into some of the varied and novel molecular networks following zebrafish exposure to diclofenac polluted waters. ..
Dios S, Balseiro P, Costa M, Romero A, BoltaÃ±a S, Roher N, et al
. The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio). Zebrafish. 2014;11:421-33 pubmed publisher
..Therefore, it is possible that the use of the whole animal could provide some clues to enhance the understanding of the inflammatory/tolerance response and to guide drug discovery. ..
Lim E, Liu Y, Chan Y, Tiinamaija T, Käräjämäki A, Madsen E, et al
. A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity. Am J Hum Genet. 2014;95:509-20 pubmed publisher
..Taken together, these data suggest that RAFT can effectively reveal rare recessive contributions to complex diseases overlooked by conventional association tests. ..
Kuang X, Liu C, Fang J, Ma W, Zhang J, Cui S. The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS Lett. 2016;590:2076-85 pubmed publisher
..Inhibition of Pdk2 in lkb1 mutants with dichloroacetate, a promising anticancer drug, rescued the lactate production to wild-type ..
Chen Q, Li C, Gong Z, Chan E, Snyder S, Lam S. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 2017;172:429-439 pubmed publisher
..The common deregulated genes with the associated biological processes and morphological changes can be used for biological inference of glucocorticoid exposure in fish for future studies. ..
Kopp R, Köblitz L, Egg M, Pelster B. HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably. Physiol Genomics. 2011;43:506-16 pubmed publisher
Kumar M, Rowley S, Fulton R, Dinday M, Baraban S, Patel M. Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome. Eneuro. 2016;3: pubmed publisher
..Our findings in scn1Lab mutant zebrafish suggest that glucose and mitochondrial hypometabolism contribute to the pathophysiology of DS. ..