Gene Symbol: pdgfba
Description: platelet-derived growth factor beta polypeptide a
Alias: pdgfb, si:ch211-79m20.1, si:dkey-261d11.1, platelet derived growth factor, B polypeptide
Species: zebrafish

Top Publications

  1. Lien C, Schebesta M, Makino S, Weber G, Keating M. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260 pubmed
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required. ..
  2. Eberhart J, He X, Swartz M, Yan Y, Song H, Boling T, et al. MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat Genet. 2008;40:290-8 pubmed publisher
    ..These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient mechanism of palatogenesis, and they provide candidate genes for cleft palate. ..
  3. Wiens K, Lee H, Shimada H, Metcalf A, Chao M, Lien C. Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. PLoS ONE. 2010;5:e11324 pubmed publisher
    ..Our data provide the first evidence that PDGFRbeta signaling is required for zebrafish angiogenesis. We propose a novel mechanism for zebrafish PDGFRbeta signaling that regulates vascular angiogenesis in the absence of mural cells. ..
  4. Zhao Y, Qin W, Zhang J, Hu Z, Tong J, Ding C, et al. HCV IRES-mediated core expression in zebrafish. PLoS ONE. 2013;8:e56985 pubmed publisher
    ..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism. ..
  5. Kartopawiro J, Bower N, Karnezis T, Kazenwadel J, Betterman K, Lesieur E, et al. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Hum Mol Genet. 2014;23:1286-97 pubmed publisher
    ..Our data refine common mechanisms that are likely to contribute during both development and the pathogenesis of lymphatic vascular disorders...