pdgfaa

Summary

Gene Symbol: pdgfaa
Description: platelet-derived growth factor alpha a
Alias: pdgfa, pdgfa-2, zgc:100777, platelet-derived growth factor alpha polypeptide
Species: zebrafish

Top Publications

  1. ncbi MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    Johann K Eberhart
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Nat Genet 40:290-8. 2008
  2. ncbi Gene expression analysis of zebrafish heart regeneration
    Ching Ling Lien
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Biol 4:e260. 2006
  3. ncbi Platelet-derived growth factor A (pdgf-a) expression during zebrafish embryonic development
    Lihui Liu
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 119260
    Dev Genes Evol 212:298-301. 2002
  4. ncbi High-resolution in situ hybridization to whole-mount zebrafish embryos
    Christine Thisse
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Nat Protoc 3:59-69. 2008
  5. ncbi Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009
  6. ncbi Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation
    Katie M Wiens
    Department of Surgery, Keck School of Medicine, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11324. 2010
  7. ncbi Zebrafish as a potential model organism for drug test against hepatitis C virus
    Cun Bao Ding
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e22921. 2011

Research Grants

  1. Developmental Compartments of the Zebrafish Neurocranium
    Johann Eberhart; Fiscal Year: 2005
  2. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2007

Scientific Experts

  • Johann K Eberhart
  • Ching Ling Lien
  • Cun Bao Ding
  • Katie M Wiens
  • Zhao Qin
  • Christine Thisse
  • Lihui Liu
  • Jing Pu Zhang
  • Dan Qing Song
  • Jian Dong Jiang
  • Ye Zhao
  • Zong Gen Peng
  • Hiroyuki Shimada
  • Hyuna L Lee
  • Michael Y Chao
  • Anthony E Metcalf
  • Pamela A Raymond
  • Linda K Barthel
  • Bernard Thisse
  • Rouwen Ge
  • Marc Ekker
  • Nararaja V Balasubramaniyan
  • Vladimir Korzh

Detail Information

Publications7

  1. ncbi MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    Johann K Eberhart
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Nat Genet 40:290-8. 2008
    ..altered palatal shape and caused neural crest cells to accumulate around the optic stalk, a source of the ligand Pdgfaa. These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient ..
  2. ncbi Gene expression analysis of zebrafish heart regeneration
    Ching Ling Lien
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Biol 4:e260. 2006
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required...
  3. ncbi Platelet-derived growth factor A (pdgf-a) expression during zebrafish embryonic development
    Lihui Liu
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 119260
    Dev Genes Evol 212:298-301. 2002
    ..Transient expression was also detected in Kupffer's vesicle, a teleost-specific structure, and in lateral trunk and tail regions surrounding the neural keel, as well as areas of the developing pronephros...
  4. ncbi High-resolution in situ hybridization to whole-mount zebrafish embryos
    Christine Thisse
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Nat Protoc 3:59-69. 2008
    ..The whole procedure takes only 3 days and, because ISH conditions are the same for each probe tested, allows high throughput analysis of zebrafish gene expression during embryogenesis...
  5. ncbi Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009
    ..Comparison of gene expression profiles from regenerating zebrafish retina, caudal fin, and heart muscle revealed additional candidate genes potentially implicated in injury-induced epimorphic regeneration in diverse zebrafish tissues...
  6. ncbi Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation
    Katie M Wiens
    Department of Surgery, Keck School of Medicine, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11324. 2010
    ..Furthermore, vascular mural cells, in which PDGFRbeta functions cell autonomously in other systems, have not been identified in zebrafish embryos younger than 72 hours post fertilization...
  7. ncbi Zebrafish as a potential model organism for drug test against hepatitis C virus
    Cun Bao Ding
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e22921. 2011
    ..Thus, zebrafish might be a model organism to host HCV, and this zebrafish/HCV (sub-replicon) system could be an animal model for anti-HCV drug screening and evaluation...

Research Grants3

  1. Developmental Compartments of the Zebrafish Neurocranium
    Johann Eberhart; Fiscal Year: 2005
    ..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
  2. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2007
    ..Additionally, two genes I propose to analyze, pitx2 and ephrin-B1, are known to be human craniofacial disease genes. Therefore, my analyses of these genes will provide direct insight into the cause of human disease. ..