pdgfaa

Summary

Gene Symbol: pdgfaa
Description: platelet-derived growth factor alpha polypeptide a
Alias: pdgfa, pdgfa-2, zgc:100777, platelet-derived growth factor alpha a
Species: zebrafish

Top Publications

  1. Eberhart J, He X, Swartz M, Yan Y, Song H, Boling T, et al. MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat Genet. 2008;40:290-8 pubmed publisher
    ..altered palatal shape and caused neural crest cells to accumulate around the optic stalk, a source of the ligand Pdgfaa. These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient ..
  2. Lien C, Schebesta M, Makino S, Weber G, Keating M. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260 pubmed
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required. ..
  3. Thisse C, Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc. 2008;3:59-69 pubmed publisher
    ..The whole procedure takes only 3 days and, because ISH conditions are the same for each probe tested, allows high throughput analysis of zebrafish gene expression during embryogenesis. ..
  4. Ding C, Zhang J, Zhao Y, Peng Z, Song D, Jiang J. Zebrafish as a potential model organism for drug test against hepatitis C virus. PLoS ONE. 2011;6:e22921 pubmed publisher
    ..Thus, zebrafish might be a model organism to host HCV, and this zebrafish/HCV (sub-replicon) system could be an animal model for anti-HCV drug screening and evaluation. ..
  5. Liu L, Korzh V, Balasubramaniyan N, Ekker M, Ge R. Platelet-derived growth factor A (pdgf-a) expression during zebrafish embryonic development. Dev Genes Evol. 2002;212:298-301 pubmed
    ..Transient expression was also detected in Kupffer's vesicle, a teleost-specific structure, and in lateral trunk and tail regions surrounding the neural keel, as well as areas of the developing pronephros. ..
  6. Wiens K, Lee H, Shimada H, Metcalf A, Chao M, Lien C. Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. PLoS ONE. 2010;5:e11324 pubmed publisher
    ..Our data provide the first evidence that PDGFRbeta signaling is required for zebrafish angiogenesis. We propose a novel mechanism for zebrafish PDGFRbeta signaling that regulates vascular angiogenesis in the absence of mural cells. ..
  7. DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, et al. Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol. 2012;12:16 pubmed publisher
    ..Cleft palate resulting from HDAC4 mutations in human patients may result from defects in a homologous CNC progenitor cell population. ..
  8. Zhao Y, Qin W, Zhang J, Hu Z, Tong J, Ding C, et al. HCV IRES-mediated core expression in zebrafish. PLoS ONE. 2013;8:e56985 pubmed publisher
    ..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism. ..
  9. Qin Z, Barthel L, Raymond P. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Proc Natl Acad Sci U S A. 2009;106:9310-5 pubmed publisher
    ..Comparison of gene expression profiles from regenerating zebrafish retina, caudal fin, and heart muscle revealed additional candidate genes potentially implicated in injury-induced epimorphic regeneration in diverse zebrafish tissues. ..

More Information

Publications12

  1. McCarthy N, Wetherill L, Lovely C, Swartz M, Foroud T, Eberhart J. Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development. 2013;140:3254-65 pubmed publisher
    ..This protective role is mediated by the PI3K/mTOR pathway. Collectively, our results suggest a model where combined genetic and environmental inhibition of PI3K/mTOR signaling leads to variability within FASD. ..
  2. Schuster K, Leeke B, Meier M, Wang Y, Newman T, Burgess S, et al. A neural crest origin for cohesinopathy heart defects. Hum Mol Genet. 2015;24:7005-16 pubmed publisher
    ..Our results give insight into the etiology of heart defects in the cohesinopathies, and raise the possibility that mild mutations in cohesin genes may be causative of a fraction of congenital heart disease in human populations. ..
  3. Bloomekatz J, Singh R, Prall O, Dunn A, Vaughan M, Loo C, et al. Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. elife. 2017;6: pubmed publisher
    ..Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra-expressing myocardial precursors...