pdgfaa

Summary

Gene Symbol: pdgfaa
Description: platelet-derived growth factor alpha a
Alias: pdgfa, pdgfa-2, zgc:100777, platelet-derived growth factor alpha polypeptide
Species: zebrafish

Top Publications

  1. pmc MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    Johann K Eberhart
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Nat Genet 40:290-8. 2008
  2. pmc Zebrafish as a potential model organism for drug test against hepatitis C virus
    Cun Bao Ding
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e22921. 2011
  3. pmc Gene expression analysis of zebrafish heart regeneration
    Ching Ling Lien
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Biol 4:e260. 2006
  4. doi Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD
    Neil McCarthy
    Department of Molecular and Cell and Developmental Biology, Institute for Cellular and Molecular Biology and Institute for Neuroscience, University of Texas, Austin, TX 78712, USA
    Development 140:3254-65. 2013
  5. pmc HCV IRES-mediated core expression in zebrafish
    Ye Zhao
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 8:e56985. 2013
  6. pmc Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton
    April DeLaurier
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 12:16. 2012
  7. pmc Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation
    Katie M Wiens
    Department of Surgery, Keck School of Medicine, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11324. 2010
  8. pmc Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009
  9. doi High-resolution in situ hybridization to whole-mount zebrafish embryos
    Christine Thisse
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Nat Protoc 3:59-69. 2008
  10. ncbi Platelet-derived growth factor A (pdgf-a) expression during zebrafish embryonic development
    Lihui Liu
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 119260
    Dev Genes Evol 212:298-301. 2002

Scientific Experts

  • Ching Ling Lien
  • April DeLaurier
  • Johann K Eberhart
  • Ye Zhao
  • Cun Bao Ding
  • Neil McCarthy
  • Jing Pu Zhang
  • Jian Dong Jiang
  • Dan Qing Song
  • Zong Gen Peng
  • Katie M Wiens
  • Zhao Qin
  • Christine Thisse
  • Lihui Liu
  • Zhan Ying Hu
  • Leah Wetherill
  • Jun Wei Tong
  • Li Xun Zhao
  • Tatiana M Foroud
  • Wei Qin
  • C Ben Lovely
  • Mary E Swartz
  • Hiroyuki Shimada
  • Hyuna L Lee
  • Anthony E Metcalf
  • Michael Y Chao
  • Pamela A Raymond
  • Linda K Barthel
  • Bernard Thisse
  • Rouwen Ge
  • Nararaja V Balasubramaniyan
  • Vladimir Korzh
  • Marc Ekker

Detail Information

Publications10

  1. pmc MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    Johann K Eberhart
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Nat Genet 40:290-8. 2008
    ..altered palatal shape and caused neural crest cells to accumulate around the optic stalk, a source of the ligand Pdgfaa. These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient ..
  2. pmc Zebrafish as a potential model organism for drug test against hepatitis C virus
    Cun Bao Ding
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e22921. 2011
    ..Thus, zebrafish might be a model organism to host HCV, and this zebrafish/HCV (sub-replicon) system could be an animal model for anti-HCV drug screening and evaluation...
  3. pmc Gene expression analysis of zebrafish heart regeneration
    Ching Ling Lien
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Biol 4:e260. 2006
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required...
  4. doi Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD
    Neil McCarthy
    Department of Molecular and Cell and Developmental Biology, Institute for Cellular and Molecular Biology and Institute for Neuroscience, University of Texas, Austin, TX 78712, USA
    Development 140:3254-65. 2013
    ..This protective role is mediated by the PI3K/mTOR pathway. Collectively, our results suggest a model where combined genetic and environmental inhibition of PI3K/mTOR signaling leads to variability within FASD. ..
  5. pmc HCV IRES-mediated core expression in zebrafish
    Ye Zhao
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 8:e56985. 2013
    ..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism...
  6. pmc Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton
    April DeLaurier
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 12:16. 2012
    ..In humans, HDAC4 deficiency is associated with non-syndromic oral clefts and brachydactyly mental retardation syndrome (BDMR) with craniofacial abnormalities...
  7. pmc Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation
    Katie M Wiens
    Department of Surgery, Keck School of Medicine, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11324. 2010
    ..Furthermore, vascular mural cells, in which PDGFRbeta functions cell autonomously in other systems, have not been identified in zebrafish embryos younger than 72 hours post fertilization...
  8. pmc Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009
    ..Comparison of gene expression profiles from regenerating zebrafish retina, caudal fin, and heart muscle revealed additional candidate genes potentially implicated in injury-induced epimorphic regeneration in diverse zebrafish tissues...
  9. doi High-resolution in situ hybridization to whole-mount zebrafish embryos
    Christine Thisse
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Nat Protoc 3:59-69. 2008
    ..The whole procedure takes only 3 days and, because ISH conditions are the same for each probe tested, allows high throughput analysis of zebrafish gene expression during embryogenesis...
  10. ncbi Platelet-derived growth factor A (pdgf-a) expression during zebrafish embryonic development
    Lihui Liu
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 119260
    Dev Genes Evol 212:298-301. 2002
    ..Transient expression was also detected in Kupffer's vesicle, a teleost-specific structure, and in lateral trunk and tail regions surrounding the neural keel, as well as areas of the developing pronephros...

Research Grants3

  1. Developmental Compartments of the Zebrafish Neurocranium
    Johann Eberhart; Fiscal Year: 2005
    ..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
  2. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2007
    ..Additionally, two genes I propose to analyze, pitx2 and ephrin-B1, are known to be human craniofacial disease genes. Therefore, my analyses of these genes will provide direct insight into the cause of human disease. ..