Gene Symbol: pde6c
Description: phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Alias: zgc:73085, cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', eclipse, pde6 alpha prime
Species: zebrafish

Top Publications

  1. Stearns G, Evangelista M, Fadool J, Brockerhoff S. A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish. J Neurosci. 2007;27:13866-74 pubmed
    ..mutant with rapid degeneration of cone photoreceptors caused by a mutation in the cone phosphodiesterase c (pde6c) gene, a key regulatory component in cone phototransduction...
  2. Lewis A, Williams P, Lawrence O, Wong R, Brockerhoff S. Wild-type cone photoreceptors persist despite neighboring mutant cone degeneration. J Neurosci. 2010;30:382-9 pubmed publisher
    ..We previously reported that the zebrafish cone phosphodiesterase mutant (pde6c(w59)) displays a rapid death of cones soon after their formation and a subsequent loss of rods in the central ..
  3. Craig S, Thummel R, Ahmed H, Vasta G, Hyde D, Hitchcock P. The zebrafish galectin Drgal1-l2 is expressed by proliferating Müller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors. Invest Ophthalmol Vis Sci. 2010;51:3244-52 pubmed publisher
    ..Drgal1-L2 is the first secreted factor shown to regulate aspects of regenerative neurogenesis in the teleost retina. ..
  4. Viringipurampeer I, Shan X, Gregory Evans K, Zhang J, Mohammadi Z, Gregory Evans C. Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell Death Differ. 2014;21:665-75 pubmed publisher
    ..In most cases, mutations have been identified in CNGA3, CNGB3, GNAT2, PDE6C or PDE6H genes...
  5. Morris A, Scholz T, Brockerhoff S, Fadool J. Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev Neurobiol. 2008;68:605-19 pubmed publisher
    ..or cone degeneration using, respectively, the XOPS-mCFP transgenic line and zebrafish with a null mutation in the pde6c gene...
  6. Zhang L, Zhang X, Zhang G, Pang C, Leung Y, Zhang M, et al. Expression profiling of the retina of pde6c, a zebrafish model of retinal degeneration. Sci Data. 2017;4:170182 pubmed publisher
    ..In this study, we measured the gene-expression profile of retinas microdissected from a zebrafish pde6cw59 (pde6c) mutant...
  7. Feng D, Chen Z, Yang K, Miao S, Xu B, Kang Y, et al. The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. J Biol Chem. 2017;292:17375-17386 pubmed publisher
    ..Our results demonstrate a previously unknown function of the rhodopsin cytoplasmic domain during opsin-triggered photoreceptor degeneration and may open up new avenues for managing this disease. ..
  8. Wang Y, Cai S, Cui J, Chen Y, Tang X, Li Y. Correlation between photoreceptor injury-regeneration and behavior in a zebrafish model. Neural Regen Res. 2017;12:795-803 pubmed publisher
    ..This study demonstrates that the zebrafish retina has a robust capacity for regeneration. Visual impairment and stress responses following high-intensity light stimulation appear to contribute to the alteration of behaviors. ..
  9. Iribarne M, Nishiwaki Y, Nakamura S, Araragi M, Oguri E, Masai I. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep. 2017;7:45962 pubmed publisher
    ..markedly decreased in the gosh mutant, and the gosh mutation genetically interacts with zebrafish pde6c mutation eclipse (els). These data suggest that Aipl1 is required for Pde6c stability and function...

More Information


  1. Taylor S, Alvarez Delfin K, Saade C, Thomas J, Thummel R, Fadool J, et al. The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling. Invest Ophthalmol Vis Sci. 2015;56:7496-515 pubmed publisher
    ..In contrast, during embryonic development, NeuroD governs photoreceptor maturation via mechanisms that are independent of Notch signaling. ..
  2. Aluru N, Jenny M, Hahn M. Knockdown of a zebrafish aryl hydrocarbon receptor repressor (AHRRa) affects expression of genes related to photoreceptor development and hematopoiesis. Toxicol Sci. 2014;139:381-95 pubmed publisher
    ..cone-specific genes such as several opsins (opn1sw1, opn1sw2, opn1mw1, and opn1lw2), phosphodiesterases (pde6H and pde6C), retinol binding protein (rbp4l), phosducin, and arrestins...
  3. Zhang L, Xiang L, Liu Y, Venkatraman P, Chong L, CHO J, et al. A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration. PLoS ONE. 2016;11:e0149663 pubmed publisher
    ..In this model, the pde6c gene (phosphodiesterase 6C, cGMP-specific, cone, alpha prime) carried a mutation which caused cone degeneration...
  4. Glaviano A, Smith A, Blanco A, McLoughlin S, Cederlund M, Heffernan T, et al. A method for isolation of cone photoreceptors from adult zebrafish retinae. BMC Neurosci. 2016;17:71 pubmed
    ..In addition, this advancement facilitates the identification of novel candidate genes for inherited human blindness. ..
  5. Rodr guez Mar A, Ca estro C, Bremiller R, Catchen J, Yan Y, Postlethwait J. Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS ONE. 2013;8:e73951 pubmed publisher
  6. Lu Z, Hu X, Liu F, Soares D, Liu X, Yu S, et al. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Sci Rep. 2017;7:46098 pubmed publisher
  7. Ma E, Lewis A, Barabas P, Stearns G, Suzuki S, Krizaj D, et al. Loss of Pde6 reduces cell body Ca(2+) transients within photoreceptors. Cell Death Dis. 2013;4:e797 pubmed publisher
    ..simultaneous analysis of cone photoreceptor morphology and Ca(2+) fluxes revealed that degeneration of pde6c(w59) mutant cones, which lack the cone-specific cGMP phosphodiesterase, is not associated with sustained increases ..
  8. Thorn R, Clift D, Ojo O, Colwill R, Creton R. The loss and recovery of vertebrate vision examined in microplates. PLoS ONE. 2017;12:e0183414 pubmed publisher
    ..The developed assays are the first to measure the loss and recovery of vertebrate vision in microplates and provide an efficient platform to evaluate novel treatments of visual impairment. ..
  9. Gramage E, D Cruz T, Taylor S, Thummel R, Hitchcock P. Midkine-a protein localization in the developing and adult retina of the zebrafish and its function during photoreceptor regeneration. PLoS ONE. 2015;10:e0121789 pubmed publisher
    ..These data suggest that during photoreceptor regeneration Mdka regulates aspects of injury-induced cell proliferation. ..
  10. Saade C, Alvarez Delfin K, Fadool J. Rod photoreceptors protect from cone degeneration-induced retinal remodeling and restore visual responses in zebrafish. J Neurosci. 2013;33:1804-14 pubmed publisher
    ..for postsynaptic glutamate receptors, significant remodeling is observed following cone degeneration in the pde6c(w59) larval retina but not rod degeneration in the Xops:mCFP(q13) line...
  11. Nishiwaki Y, Komori A, Sagara H, Suzuki E, Manabe T, Hosoya T, et al. Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish. Mech Dev. 2008;125:932-46 pubmed publisher
    ..We isolated a zebrafish mutant, called eclipse (els), which shows no visual behavior such as optokinetic response (OKR)...