Gene Symbol: pde6b
Description: phosphodiesterase 6B, cGMP-specific, rod, beta
Alias: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Nakao T, Tsujikawa M, Notomi S, Ikeda Y, Nishida K. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS ONE. 2012;7:e32472 pubmed publisher
..In short, our study indicates that in some RP, adenylyl cyclase is involved in photoreceptor cell death pathway; its inhibition is potentially a logical approach for a novel RP therapy. ..
Viringipurampeer I, Shan X, Gregory Evans K, Zhang J, Mohammadi Z, Gregory Evans C. Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell Death Differ. 2014;21:665-75 pubmed publisher
..larvae, visual function was restored in the cones by upregulation of the rod phosphodiesterase genes (pde6a and pde6b), compensating for the lack of cone pde6c suggesting that cones are able to adapt to their local environment...
Liu F, Qin Y, Yu S, Soares D, Yang L, Weng J, et al
. Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. J Biol Chem. 2017;292:6225-6239 pubmed publisher
..Our study also reveals a role of the C-terminal domain of RP2 in maintaining the overall protein stability. ..
Lu Z, Hu X, Liu F, Soares D, Liu X, Yu S, et al
. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Sci Rep. 2017;7:46098 pubmed publisher
Nishiwaki Y, Komori A, Sagara H, Suzuki E, Manabe T, Hosoya T, et al
. Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish. Mech Dev. 2008;125:932-46 pubmed publisher
..Taken together, these data suggest that PDE6alpha' activity is important for the survival of cones in zebrafish. ..