Gene Symbol: pcsk5b
Description: proprotein convertase subtilisin/kexin type 5b
Alias: pcsk5, zgc:165659, proprotein convertase subtilisin/kexin type 5, pc5.2, pcsk5.2
Khatib A, Lahlil R, Scamuffa N, Akimenko M, Ernest S, Lomri A, et al
. Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. PLoS ONE. 2010;5:e11438 pubmed publisher
..Taken together, these data indicate that zebrafish fin regeneration is associated with up-regulation of VEGF-C and the convertases Furin and PC5 and highlight the inhibitory effect of unprocessed proVEGF-C on fin regeneration. ..
Turpeinen H, Oksanen A, Kivinen V, Kukkurainen S, Uusimäki A, Ramet M, et al
. Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor ?1a (TGF?1a). J Biol Chem. 2013;288:36610-23 pubmed publisher
..Targeting PCSK activity has emerged as a strategy for treating human diseases. Our results suggest that inhibiting PCSK7 might interfere with normal vertebrate development. ..
Ma J, Evrard S, Badiola I, Siegfried G, Khatib A. Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). Eur J Cell Biol. 2017;96:457-468 pubmed publisher
Chitramuthu B, Baranowski D, Cadieux B, Rousselet E, Seidah N, Bennett H. Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development. Dev Dyn. 2010;239:2933-46 pubmed publisher
..roles, we have cloned the cDNA sequences encoding two candidate zebrafish PC5 convertases (designated as PCSK5.1 and PCSK5.2) co-orthologous to the single PC5 encoding gene (PCSK5) found in mammals...
Chitramuthu B, Bennett H. High resolution whole mount in situ hybridization within zebrafish embryos to study gene expression and function. J Vis Exp. 2013;:e50644 pubmed publisher
..By employing a chromogenic substrate for alkaline phosphatase, specific gene expression can be assessed. Depending on the level of gene expression the entire procedure can be completed within 2-3 days. ..
Ojanen M, Turpeinen H, Cordova Z, HammarÃ©n M, Harjula S, Parikka M, et al
. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..