Gene Symbol: pcdh15a
Description: protocadherin-related 15a
Alias: PCDH15, si:bac7cse.1, si:xx-bac7cse.1, protocadherin-related 15a, orb, orbiter, procadherin, protocadherin 15a, protocadherin 15a CD3 isoform
Species: zebrafish

Top Publications

  1. Nicolson T. The genetics of hearing and balance in zebrafish. Annu Rev Genet. 2005;39:9-22 pubmed
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish. ..
  2. Maeda R, Kindt K, Mo W, Morgan C, Erickson T, Zhao H, et al. Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proc Natl Acad Sci U S A. 2014;111:12907-12 pubmed publisher
    ..two-hybrid screen to identify proteins that bind to PCDH15, we detected an interaction between zebrafish Pcdh15a and an N-terminal fragment of transmembrane channel-like 2a (Tmc2a)...
  3. Maeda R, Pacentine I, Erickson T, Nicolson T. Functional Analysis of the Transmembrane and Cytoplasmic Domains of Pcdh15a in Zebrafish Hair Cells. J Neurosci. 2017;37:3231-3245 pubmed publisher
    ..Here, we examined the localization and function of the two isoforms of zebrafish Pcdh15a (CD1 and CD3) in pcdh15a-null mutants by assessing Pcdh15a transgene-mediated rescue of auditory/..
  4. Nicolson T, Rusch A, Friedrich R, Granato M, Ruppersberg J, Nusslein Volhard C. Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants. Neuron. 1998;20:271-83 pubmed
    ..Mutant orbiter, mercury, and gemini larvae have normal hair cell morphology and yet do not respond to acoustic-vibrational ..
  5. SHEETS L, Trapani J, Mo W, Obholzer N, Nicolson T. Ribeye is required for presynaptic Ca(V)1.3a channel localization and afferent innervation of sensory hair cells. Development. 2011;138:1309-19 pubmed publisher
    ..3a channels at the presynapse and stabilizing contacts with afferent neurons--and suggest that Ribeye plays an organizing role in synaptogenesis. ..
  6. Toro C, Trapani J, Pacentine I, Maeda R, SHEETS L, Mo W, et al. Dopamine Modulates the Activity of Sensory Hair Cells. J Neurosci. 2015;35:16494-503 pubmed publisher
    ..The mechanism of dopamine activation requires voltage-gated calcium channels that are also present at hair-cell synapses. ..
  7. Erickson T, Morgan C, Olt J, Hardy K, Busch Nentwich E, Maeda R, et al. Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). elife. 2017;6: pubmed publisher
    ..Thus, we propose a model of MET complex assembly where Tomt and the Tmcs interact within the secretory pathway to traffic Tmc proteins to the hair bundle. ..
  8. Goodman L, Zallocchi M. Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells. J Cell Sci. 2017;130:3698-3712 pubmed publisher
    ..Here, we describe the existence of an integrin α8 (Itga8) and protocadherin-15a (Pcdh15a) ciliary complex in neuromast hair cells in a zebrafish model...
  9. Seiler C, Nicolson T. Defective calmodulin-dependent rapid apical endocytosis in zebrafish sensory hair cell mutants. J Neurobiol. 1999;41:424-34 pubmed
    ..lateral line and inner ear hair cells were found in five zebrafish auditory/vestibular mutants: sputnik, mariner, orbiter, mercury, and skylab...

More Information


  1. Seiler C, Finger Baier K, Rinner O, Makhankov Y, Schwarz H, Neuhauss S, et al. Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development. 2005;132:615-23 pubmed
    ..Mutations in pcdh15a cause deafness and vestibular dysfunction, presumably because hair bundles of inner-ear receptors are splayed...
  2. Yin V, Lepilina A, Smith A, Poss K. Regulation of zebrafish heart regeneration by miR-133. Dev Biol. 2012;365:319-27 pubmed publisher
    ..Our results reveal dynamic regulation of miRNAs during heart regeneration, and indicate that miR-133 restricts injury-induced cardiomyocyte proliferation. ..
  3. Ogun O, Zallocchi M. Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly. J Cell Biol. 2014;207:375-91 pubmed publisher
    ..We also observed an in vivo interaction between clarin-1 and Pcdh15a. Altogether, our results suggest that clarin-1 is functionally important for mechanotransduction channel activity ..