Gene Symbol: pax9
Description: paired box 9
Alias: paired box protein Pax-9, etID309776.17, paired box gene 9, paired box homeotic gene 9
Species: zebrafish
Products:     pax9

Top Publications

  1. Liu X, Wang H, Li G, Huang H, Wang Y. The function of DrPax1b gene in the embryonic development of zebrafish. Genes Genet Syst. 2013;88:261-9 pubmed
  2. Stock D. Zebrafish dentition in comparative context. J Exp Zool B Mol Dev Evol. 2007;308:523-49 pubmed
    ..Such studies may reveal the relative contribution to trends in dental evolution of biases in the generation of variation and sorting of this variation by selection or drift...
  3. Kawamura A, Koshida S, Hijikata H, Ohbayashi A, Kondoh H, Takada S. Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Dev Cell. 2005;9:735-44 pubmed
    ..Thus, ripply1 plays dual roles in the transition from the PSM to somites: termination of the segmentation program in the PSM and maintenance of the rostrocaudal polarity. ..
  4. Chatterjee S, Bourque G, Lufkin T. Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes. BMC Dev Biol. 2011;11:63 pubmed publisher
    ..2, pax9, otx1b and foxa2) in zebrafish, only 20-30% of highly conserved DNA sequences can act as developmental enhancers ..
  5. Bolli N, Payne E, Rhodes J, Gjini E, Johnston A, Guo F, et al. cpsf1 is required for definitive HSC survival in zebrafish. Blood. 2011;117:3996-4007 pubmed publisher
    ..These studies show that cpsf1 is essential for HSC survival and differentiation in caudal hematopoietic tissue. ..
  6. Hayes M, Gao X, Yu L, Paria N, Henkelman R, Wise C, et al. ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease. Nat Commun. 2014;5:4777 pubmed publisher
    ..Our data suggest novel molecular origins of, and genetic links between, congenital and idiopathic forms of disease. ..
  7. Kudo H, Amizuka N, Araki K, Inohaya K, Kudo A. Zebrafish periostin is required for the adhesion of muscle fiber bundles to the myoseptum and for the differentiation of muscle fibers. Dev Biol. 2004;267:473-87 pubmed
  8. Fisher S, Halpern M. Patterning the zebrafish axial skeleton requires early chordin function. Nat Genet. 1999;23:442-6 pubmed
    ..Our results demonstrate that chordin function during gastrulation is important for the correct morphogenesis of the adult zebrafish skeleton. ..
  9. Chen X, Huang H, Wang H, Guo F, Du X, Ma L, et al. Characterization of zebrafish Pax1b and Pax9 in fin bud development. Biomed Res Int. 2014;2014:309385 pubmed publisher
    Both Pax1 and Pax9 belong to the important paired box gene family (PAX), which mainly participates in animal development and sclerotome differentiation...

More Information


  1. Fleming A, Keynes R, Tannahill D. A central role for the notochord in vertebral patterning. Development. 2004;131:873-80 pubmed
    ..These findings suggest that the notochord plays a key, perhaps ancient, role in the segmental patterning of vertebrae. ..
  2. Pietsch J, Delalande J, Jakaitis B, Stensby J, Dohle S, Talbot W, et al. lessen encodes a zebrafish trap100 required for enteric nervous system development. Development. 2006;133:395-406 pubmed
    ..These studies demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of ENS precursors in the intestine. ..
  3. Swartz M, Sheehan Rooney K, Dixon M, Eberhart J. Examination of a palatogenic gene program in zebrafish. Dev Dyn. 2011;240:2204-20 pubmed publisher
    ..Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis...
  4. Majumdar A, Drummond I. The zebrafish floating head mutant demonstrates podocytes play an important role in directing glomerular differentiation. Dev Biol. 2000;222:147-57 pubmed
    ..Furthermore, we find defects in sclerotomal development that correlate with defects in glomerular morphogenesis suggesting a possible link between the formation of these embryonic structures. ..
  5. Takke C, Campos Ortega J. her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Development. 1999;126:3005-14 pubmed
    ..Whereas notch signalling alone apparently does not affect myogenesis, zebrafish groucho2 is involved in differentiation of mesodermal derivatives. ..
  6. Amigo J, Ackermann G, Cope J, Yu M, Cooney J, Ma D, et al. The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 2009;114:4654-63 pubmed publisher
    ..One of these enhancers contains functional GATA-binding sites, indicating the potential for a regulatory loop in which GATA factors control the expression of their partner protein FOG-1. ..
  7. Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher
    ..These findings have implications for mechanisms of positional memory in vertebrate tissues. ..
  8. Phillips C, Butler B, Fondon J, Mantilla Meluk H, Baker R. Contrasting evolutionary dynamics of the developmental regulator PAX9, among bats, with evidence for a novel post-transcriptional regulatory mechanism. PLoS ONE. 2013;8:e57649 pubmed publisher
    ..The paired-domain gene, PAX9, is known to be a key regulator of development, particularly of the face and teeth...
  9. Chen H, Beasley A, Hu Y, Chen X. A Zebrafish Model for Studies on Esophageal Epithelial Biology. PLoS ONE. 2015;10:e0143878 pubmed publisher
    ..Expression of esophageal epithelial marker genes (Krt5, P63, Sox2 and Pax9) was detected by immunohistochemistry and in situ hybridization...
  10. Yuan Q, Zhao M, Tandon B, Maili L, Liu X, Zhang A, et al. Role of WNT10A in failure of tooth development in humans and zebrafish. Mol Genet Genomic Med. 2017;5:730-741 pubmed publisher
  11. Laue K, Daujat S, Crump J, Plaster N, Roehl H, Kimmel C, et al. The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development. 2008;135:1935-46 pubmed publisher
    ..We conclude that Brpf1, coordinated by its particular set of domains, acts by multiple mechanisms to mediate Moz-dependent histone acetylation and to mark Hox genes for maintained expression throughout vertebrate development. ..
  12. Kinkel M, Eames S, Alonzo M, Prince V. Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number. Development. 2008;135:919-29 pubmed publisher
    ..In support of this, we demonstrate that in cdx4-deficient embryos treated with RA, ectopic beta-cells are located well posterior to the normal pancreatic domain. ..
  13. Stock D, Jackman W, Trapani J. Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes. Development. 2006;133:3127-37 pubmed publisher
    ..We hypothesize that a loss of Fgf signaling to oral epithelium was associated with cypriniform tooth loss...
  14. Okabe M, Graham A. The origin of the parathyroid gland. Proc Natl Acad Sci U S A. 2004;101:17716-9 pubmed publisher
  15. Jackman W, Draper B, Stock D. Fgf signaling is required for zebrafish tooth development. Dev Biol. 2004;274:139-57 pubmed
    ..differences in gene expression between zebrafish and mouse teeth are indicated by the apparent lack of fgf8 and pax9 expression in zebrafish tooth germs...
  16. Konig C, Yan Y, Postlethwait J, Wendler S, Campos Ortega J. A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. Mech Dev. 1999;86:17-28 pubmed
    ..The results of this study are discussed in the light of the possible function of the guanylate kinase domain. ..
  17. Nornes S, Clarkson M, Mikkola I, Pedersen M, Bardsley A, Martinez J, et al. Zebrafish contains two pax6 genes involved in eye development. Mech Dev. 1998;77:185-96 pubmed
  18. Nornes S, Mikkola I, Krauss S, Delghandi M, Perander M, Johansen T. Zebrafish Pax9 encodes two proteins with distinct C-terminal transactivating domains of different potency negatively regulated by adjacent N-terminal sequences. J Biol Chem. 1996;271:26914-23 pubmed
    We describe the isolation of cDNA clones for zebrafish Pax9. Pax9 expression was initiated at the end of the segmentation period in mesenchymal sclerotome cells on both sides of the notochord similarly to the corresponding mouse and chick ..