pax2b

Summary

Gene Symbol: pax2b
Description: paired box 2b
Alias: pax2.2, paired box 2b, paired box gene 2b
Species: zebrafish
Products:     pax2b

Top Publications

  1. Mackereth M, Kwak S, Fritz A, Riley B. Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode. Development. 2005;132:371-82 pubmed
    ..Disrupting pax8, pax2a and pax2b did not further impair otic induction relative to loss of pax8 alone...
  2. Bricaud O, Collazo A. The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. J Neurosci. 2006;26:10438-51 pubmed
    ..six1 does not appear to be dependent on eya1, although it seems to be important for the regulation of eya1 and pax2b expression in the ventral otic epithelium...
  3. Millimaki B, Sweet E, Dhason M, Riley B. Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch. Development. 2007;134:295-305 pubmed
    ..A model is presented in which zebrafish atoh1 genes operate in a complex network leading to hair cell development. ..
  4. O Hara F, Beck E, Barr L, Wong L, Kessler D, Riddle R. Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer. Development. 2005;132:3163-73 pubmed
    ..We propose that Lmx1b.1- and Lmx1b.2-mediated regulation of wnt1, wnt3a, wnt10b, pax8 and fgf8 maintains cell survival in the isthmocerebellar region. ..
  5. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..These results significantly increase our understanding of the mechanisms of neuronal specification and the genetic networks involved in these processes. ..
  6. Lin C, Spikings E, Zhang T, Rawson D. Effect of chilling and cryopreservation on expression of Pax genes in zebrafish (Danio rerio) embryos and blastomeres. Cryobiology. 2009;59:42-7 pubmed publisher
    ..we used real-time RT-PCR analysis to determine the effect of chilling and cryopreservation on expression of Pax2a, Pax2b, Pax5 and Pax8 which constitute one subgroup of the Pax gene family...
  7. Topczewska J, Postovit L, Margaryan N, Sam A, Hess A, Wheaton W, et al. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med. 2006;12:925-32 pubmed
    ..These data suggest that Nodal signaling has a key role in melanoma cell plasticity and tumorigenicity, thereby providing a previously unknown molecular target for regulating tumor progression. ..
  8. Padanad M, Riley B. Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24. Dev Biol. 2011;351:90-8 pubmed publisher
    ..Subsequently, pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development...
  9. Sanek N, Taylor A, Nyholm M, Grinblat Y. Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression. Development. 2009;136:3791-800 pubmed publisher
    ..These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE. ..

More Information

Publications20

  1. Stenkamp D, Frey R. Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish. Dev Biol. 2003;258:349-63 pubmed
  2. Coyle R, Latimer A, Jessen J. Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling. Exp Cell Res. 2008;314:2150-62 pubmed publisher
    ..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration. ..
  3. Chao R, Nevin L, Agarwal P, Riemer J, Bai X, Delaney A, et al. A male with unilateral microphthalmia reveals a role for TMX3 in eye development. PLoS ONE. 2010;5:e10565 pubmed publisher
    ..Future experiments to determine if other thioredoxins are important in eye morphogenesis and to clarify the mechanism of function of TMX3 in eye development are warranted. ..
  4. Woolfe A, Elgar G. Comparative genomics using Fugu reveals insights into regulatory subfunctionalization. Genome Biol. 2007;8:R53 pubmed
    ..Comparative analysis of conserved elements between duplicated genes provides a powerful approach for studying regulatory subfunctionalization at the level of the regulatory elements involved. ..
  5. Choe S, Ladam F, SAGERSTROM C. TALE factors poise promoters for activation by Hox proteins. Dev Cell. 2014;28:203-11 pubmed publisher
    ..We conclude that TALE factors access promoters during early embryogenesis to poise them for activation but that Hox proteins are required to trigger efficient transcription. ..
  6. Batista M, Lewis K. Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Dev Biol. 2008;323:88-97 pubmed publisher
    ..In this paper, we show that in zebrafish most glycinergic and many GABAergic spinal interneurons express Pax2a, Pax2b and Pax8 and that these transcription factors are redundantly required for the neurotransmitter fates of many of ..
  7. Albuixech Crespo B, López Blanch L, Burguera D, Maeso I, Sánchez Arrones L, Moreno Bravo J, et al. Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biol. 2017;15:e2001573 pubmed publisher
    ..This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice. ..
  8. Kiener T, Selptsova Friedrich I, Hunziker W. Tjp3/zo-3 is critical for epidermal barrier function in zebrafish embryos. Dev Biol. 2008;316:36-49 pubmed publisher
    ..Thus, Tjp3/Zo-3 is critical for barrier function of the enveloping cell layer and osmoregulation in early stages of zebrafish development. ..
  9. Jessen J, Topczewski J, Bingham S, Sepich D, Marlow F, Chandrasekhar A, et al. Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nat Cell Biol. 2002;4:610-5 pubmed
    ..We propose Trilobite/Stbm mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis. ..
  10. Liao W, Ho C, Yan Y, Postlethwait J, Stainier D. Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development. 2000;127:4303-13 pubmed
    ..Together, these data provide the initial framework of a pathway that can be used to further integrate the molecular events regulating hemangioblast differentiation. ..
  11. Lackmann M, Oates A, Dottori M, Smith F, Do C, Power M, et al. Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. J Biol Chem. 1998;273:20228-37 pubmed
    ..We propose a two-step mechanism of Eph receptor activation with distinct ligand binding and ligand-independent receptor-receptor oligomerization events. ..