pax2a

Summary

Gene Symbol: pax2a
Description: paired box gene 2a
Alias: PAXZF-B, Pax-2, cb378, noi, pax-b, pax2.1, pax2a1, pax[zf-b], paxb, no isthmus protein, paired box gene 2.1, paired box homeotic gene 2a, paired box protein Pax-2a
Species: zebrafish

Top Publications

  1. ncbi The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
  2. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004
  3. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
  4. ncbi Developmental expression of zebrafish emx1 during early embryogenesis
    Atsuo Kawahara
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Gene Expr Patterns 2:201-6. 2002
  5. ncbi Differential regulation of chordin expression domains in mutant zebrafish
    V E Miller-Bertoglio
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Dev Biol 192:537-50. 1997
  6. doi Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
    Abbhirami Rajagopal
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Nature 453:1127-31. 2008
  7. pmc Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system
    Timothy Erickson
    Department of Biological Sciences, University of Alberta, CW405, Biological Sciences Bldg, Edmonton T6G 2E9, Canada
    Neural Dev 5:22. 2010
  8. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
  9. doi Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros
    Celine Burckle
    INSERM U983, Tour Lavoisier, Hopital Necker Enfants Malades, 149 rue de Sevres, Paris, France
    Hum Mol Genet 20:2611-27. 2011
  10. pmc Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    Avinash Persaud
    Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    EMBO J 30:3259-73. 2011

Detail Information

Publications149 found, 100 shown here

  1. ncbi The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
    ....
  2. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004
    ..cells respond to Fgf signals from adjacent tissues and express two highly related paired box transcription factors Pax2a and Pax8 in the developing placode...
  3. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
    ..Depletion of either dlx3b and dlx4b or foxi1 leads to a delay of pax2a expression in the otic primordia and reduction of the otic vesicle...
  4. ncbi Developmental expression of zebrafish emx1 during early embryogenesis
    Atsuo Kawahara
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Gene Expr Patterns 2:201-6. 2002
    ..Thus, emx1 displays a unique expression pattern that is distinct from the patterns of emx2 and emx3...
  5. ncbi Differential regulation of chordin expression domains in mutant zebrafish
    V E Miller-Bertoglio
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Dev Biol 192:537-50. 1997
    ..1989), while axial mesodermal expression was affected. This finding reveals an unexpected function for spadetail in midline mesoderm and in differential regulation of chordin expression during gastrulation...
  6. doi Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
    Abbhirami Rajagopal
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Nature 453:1127-31. 2008
    ..Thus, uncovering the mechanisms of haem transport in C. elegans may provide insights into human disorders of haem metabolism and reveal new drug targets for developing anthelminthics to combat worm infestations...
  7. pmc Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system
    Timothy Erickson
    Department of Biological Sciences, University of Alberta, CW405, Biological Sciences Bldg, Edmonton T6G 2E9, Canada
    Neural Dev 5:22. 2010
    ..Meis1 is a TALE-class homeodomain transcription factor known to specify anterior-posterior identity in the hindbrain, but its role in visual system patterning has not been investigated...
  8. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish...
  9. doi Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros
    Celine Burckle
    INSERM U983, Tour Lavoisier, Hopital Necker Enfants Malades, 149 rue de Sevres, Paris, France
    Hum Mol Genet 20:2611-27. 2011
    ..Moreover, they highlight common signalling functions for inversin and nephrocystin-4, suggesting that these two nephrocystins are involved in common physiopathological mechanisms...
  10. pmc Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    Avinash Persaud
    Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    EMBO J 30:3259-73. 2011
    ..These results identify Nedd4-1 as a key regulator of FGFR1 endocytosis and signalling during neuronal differentiation and embryonic development...
  11. ncbi Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Development 130:4337-49. 2003
    ..Analysis of embryos treated with an FGFR inhibitor suggests that continuous FGF signalling is required from gastrulation stages for normal forebrain patterning, and identifies additional requirements for FGFR activity...
  12. ncbi Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
    Susumu Yamashita
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 429:298-302. 2004
    ..Furthermore, we demonstrate that LIV1 is essential for the nuclear localization of zinc-finger protein Snail, a master regulator of EMT. These results establish a molecular link between STAT3, LIV1 and Snail in EMT...
  13. doi Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding
    Heike Diekmann
    Department of Biology, Universitat Konstanz, Konstanz, Germany
    J Comp Neurol 513:38-50. 2009
    ..Without Neurolin-b, RGC axons grow in highly aberrant routes along the optic tract and/or fail to reach the optic tectum. Thus, the zebrafish Neurolin paralogs are involved in distinct steps of retinotectal development...
  14. ncbi Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent
    Shun Kuo Sun
    Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 303:675-86. 2007
    ....
  15. ncbi Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis
    Yu chi Shen
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
    Dev Biol 269:237-51. 2004
    ..These results suggest novel functions for zebrafish crx during retinal specification and differentiation...
  16. pmc Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e3926. 2008
    ..Elevated expression of IGFBP-2 is often associated with progression of many types of cancers...
  17. pmc Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation
    Yong I Cha
    Department of Medicine and Cancer Biology, Cell and Developmental Biology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 2279, USA
    Genes Dev 20:77-86. 2006
    ..This work demonstrates a critical requirement of PGE(2) signaling in promoting cell motility through the COX-1-Ptges-EP4 pathway, a previously unrecognized role for this biologically active lipid in early animal development...
  18. ncbi Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary
    Arne C Lekven
    Department of Biology, Texas A and M University, 3258 TAMU, College Station, TX 77843 3258, USA
    Dev Biol 254:172-87. 2003
    ..1 or Fgf8; that is, in combination with mutant alleles of either of these loci, the morphological MHB is lost. Thus, wnt1 and wnt10b are required to maintain threshold levels of Pax2.1 and Fgf8 at the MHB...
  19. pmc The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis
    Jennifer A Tucker
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Cell 14:108-19. 2008
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously...
  20. pmc Inhibition of histone deacetylase expands the renal progenitor cell population
    Eric D de Groh
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Am Soc Nephrol 21:794-802. 2010
    ..In summary, these results support a mechanistic link among renal progenitor cells, HDAC, and the retinoid pathway. Whether PTBA holds promise as a therapeutic agent to promote renal regeneration requires further study...
  21. ncbi Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia
    A Majumdar
    Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 127:2089-98. 2000
    ..Morphological analysis demonstrates that noi(- )larvae specifically lack pronephric tubules while glomerular cell differentiation is unaffected...
  22. ncbi Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development
    Julia Horsfield
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Mech Dev 115:15-26. 2002
    ..This finding contrasts with the role of mammalian CDH17, which does not appear to be involved in nephric development...
  23. ncbi Guidance of primordial germ cell migration by the chemokine SDF-1
    Maria Doitsidou
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    Cell 111:647-59. 2002
    ..Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs...
  24. pmc Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 351:90-8. 2011
    ..Subsequently, pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development...
  25. pmc dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity
    Robert Esterberg
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Dev Biol 325:189-99. 2009
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction...
  26. doi The deubiquitylating enzyme Cops6 regulates different developmental processes during early zebrafish embryogenesis
    William K F Tse
    Laboratory of Developmental Signalling and Patterning, Genes and Development Division, Institute of Molecular and Cell Biology, Singapore
    Int J Dev Biol 55:19-24. 2011
    ..Overall, the present study that consolidates our previous work on zebrafish DUB genes, corroborates the hypothesis of multi-functional roles for DUB genes during development...
  27. pmc Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
    Rafael E Hernandez
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Development 134:177-87. 2007
    ..We present a ;gradient-free' model for hindbrain patterning in which differential RA responsiveness along the hindbrain anterior-posterior axis is shaped primarily by the dynamic expression of RA-degrading enzymes...
  28. doi Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio)
    Daniela Zizioli
    Department of Biomedical Sciences and Biotechnology, Unit of Biochemistry and Unit of Biology GB, University of Brescia, Brescia, Italy
    Dev Dyn 239:2404-12. 2010
    ..Development ceased at 7-8 dpf. μ1B is not expressed in murine liver, indicating loss of μ1B expression and establishment of alternative sorting mechanisms during mammalian development...
  29. doi FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development
    Satoshi Ota
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama, Japan
    Genesis 48:707-16. 2010
    ..1/fgf8a mutants, we found that fgfr expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis, revealing the presence of an autoregulatory mechanism...
  30. ncbi Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity
    Ricardo G Correa
    The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Curr Biol 15:1291-5. 2005
    ..Here, we report that Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB...
  31. ncbi Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
    F Reifers
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:2381-95. 1998
    ..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others...
  32. ncbi Cadherin-6 is required for zebrafish nephrogenesis during early development
    Fumitaka Kubota
    Neuromuscular and Developmental Anatomy, Gunma University Graduate School of Medicine, Gunma, Japan
    Int J Dev Biol 51:123-9. 2007
    ..These results suggest that cdh6 plays pivotal roles in the development of the pronephros in zebrafish embryos...
  33. ncbi Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation
    V Korzh
    Institute of Molecular Agrobiology, National University of Singapore, Singapore
    Dev Dyn 213:92-104. 1998
    ..This supports the idea that expression of nrd is a necessary step leading toward overt neuronal differentiation...
  34. ncbi Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development
    Ujwal J Pyati
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Development 132:2333-43. 2005
    ..We conclude that the role of Bmp signaling in the ventral and posterior mesoderm changes as gastrulation proceeds...
  35. pmc Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity
    Shalini Mitra
    Department of Medicine Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e41816. 2012
    ....
  36. doi Cystein-serine-rich nuclear protein 1, Axud1/Csrnp1, is essential for cephalic neural progenitor proliferation and survival in zebrafish
    Carmen G Feijóo
    Center for Genomics of the Cell, Facultad de Ciencias, Universidad Chile, Santiago, Chile
    Dev Dyn 238:2034-43. 2009
    ..Thus, we provide evidence as to the role of axud1 in brain growth in vertebrates...
  37. pmc A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies
    Hemant Khanna
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 41:739-45. 2009
    ..Our data represent an example of modification of a discrete phenotype of syndromic disease and highlight the importance of a multifaceted approach for the discovery of modifier alleles of intermediate frequency and effect...
  38. pmc High mobility group box-1 (HMGB1; amphoterin) is required for zebrafish brain development
    Xiang Zhao
    Neuroscience Center, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 286:23200-13. 2011
    ..Our data demonstrate that HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures...
  39. ncbi Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics, Department of Genetics, University of Technology TU, 01307, Dresden, Germany
    Dev Genes Evol 214:285-95. 2004
    ..The expression patterns of fgfr1 and fgf8 are strikingly similar and knock-down of fgfr1 phenocopies many aspects observed in the fgf8 mutant acerebellar, suggesting that Fgf8 exerts its function mainly by binding to FgfR1...
  40. ncbi A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary
    K Lun
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:3049-62. 1998
    ..Mutations in the zebrafish no isthmus (noi) gene alter development of the MHB, and affect the pax2.1 gene (formerly pax(zf-b))...
  41. doi Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
    Carmen C Leitch
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
    Nat Genet 40:443-8. 2008
    ..These data extend the genetic stratification of ciliopathies and suggest that BBS and MKS, although distinct clinically, are allelic forms of the same molecular spectrum...
  42. ncbi dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula
    Takao Kaji
    Department of Craniofacial Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Dev Biol 276:523-40. 2004
    ..These data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via BMP activity...
  43. ncbi The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling
    Atsushi Kawakami
    Department of Biological Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Curr Biol 15:480-8. 2005
    ..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites...
  44. pmc Identification of a novel retinoid by small molecule screening with zebrafish embryos
    Chetana Sachidanandan
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 3:e1947. 2008
    ....
  45. ncbi vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish
    Rafael E Hernandez
    Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Development 131:4511-20. 2004
    ..The different requirements for vhnf1 and val to repress hoxb1a and ephrin-B2a, respectively, demonstrate that not all aspects of an individual rhombomere's identity are regulated coordinately...
  46. ncbi The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis
    Shawn Burgess
    Massachusetts Institute of Technology, Center for Cancer Research, E17 340, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Development 129:905-16. 2002
    ....
  47. ncbi A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
    S Krauss
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, Oxford, England
    Cell 75:1431-44. 1993
    ..By expressing shh in transgenic Drosophila embryos, we also demonstrate a strong functional conservation between the fish and fly hh genes...
  48. pmc Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure
    Jacob D Brown
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:1462-7. 2009
    ..We also identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure...
  49. ncbi Expression pattern of zebrafish pax genes suggests a role in early brain regionalization
    S Krauss
    Molecular Genetics Group, University of Tromsø, Norway
    Nature 353:267-70. 1991
    ....
  50. ncbi Cyclooxygenase-1 signaling is required for vascular tube formation during development
    Yong I Cha
    Department of Medicine, Cell and Developmental Biology and Cancer Biology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Vanderbilt University, 694 Preston Research Building, 2300 Pierce Ave, Nashville, TN 37232, USA
    Dev Biol 282:274-83. 2005
    ..Together, we provide the first evidence that COX-1 signaling is required for development of posterior mesoderm organs, specifically in the vascular tube formation and posterior nephric duct development...
  51. ncbi A reporter-assisted mutagenesis screen using alpha 1-tubulin-GFP transgenic zebrafish uncovers missteps during neuronal development and axonogenesis
    Abhilasha Gulati-Leekha
    Molecular and Behavioral Neuroscience Institute, Department of Biological Chemistry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 070, USA
    Dev Biol 296:29-47. 2006
    ..Molecular identification of these loci and analysis of the remaining mutational repertoire will offer unique insights into the genetic inputs that go on to make a mature, differentiated neuron...
  52. ncbi Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish
    M Kobayashi
    Department of Biology, Jichi Medical School, Minamikawachi, Tochigi 329 0498, Japan
    Development 125:2973-82. 1998
    ..Our results suggest that the vertebrate Six3 genes are involved in the formation of the rostral forebrain...
  53. ncbi Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation
    B Schmid
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, Philadelphia, PA 19104 6058, USA
    Development 127:957-67. 2000
    ....
  54. ncbi Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish
    M Nikaido
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060 0812, Japan
    Mech Dev 82:219-22. 1999
    ..Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner...
  55. ncbi Pax2.1 is required for the development of thyroid follicles in zebrafish
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Köln, Germany
    Development 129:3751-60. 2002
    ..1 mutant no isthmus (noi(-/-)) demonstrates that pax2...
  56. ncbi Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Development 130:4881-93. 2003
    ..This provides an example of a mechanism needed to maintain the subdivision of the anterior neural plate into forebrain and midbrain...
  57. ncbi Regulatory gene expression patterns reveal transverse and longitudinal subdivisions of the embryonic zebrafish forebrain
    G Hauptmann
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 91:105-18. 2000
    ..Our data suggest a strong conservation of early forebrain organization between lower and higher vertebrates...
  58. doi Cadmium inhibits neurogenesis in zebrafish embryonic brain development
    Elly Suk Hen Chow
    Division of Biology, California Institute of Technology, 1200 California Boulevard, Pasadena, CA 91125, USA
    Aquat Toxicol 87:157-69. 2008
    ..Our data suggest that cadmium-induced neurotoxicity can be caused by impaired neurogenesis, resulting in markedly reduced neuronal differentiation and axonogenesis...
  59. pmc Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries
    Timothy Erickson
    Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton AB, Canada T6G2E9
    Dev Biol 301:504-17. 2007
    ..Embryos lacking Pbx function correctly initiate midbrain patterning, but fail to maintain eng2a, pax2a, fgf8, gbx2, and wnt1 expression at the MHB...
  60. pmc Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 238:1207-13. 2009
    ..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart...
  61. ncbi Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid
    Lisa Maves
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Dev Biol 285:593-605. 2005
    ..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities...
  62. ncbi Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo
    Diana M Ho
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Dev Biol 295:730-42. 2006
    ..The combination of the ALK inhibitor SB-431542 with inhibitor-resistant ALKs provides a powerful set of tools for examining nodal/activin signaling during embryogenesis...
  63. pmc Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish
    Engda G Hagos
    Department of Cellular Biology, The University of Georgia, Athens, GA, USA
    BMC Dev Biol 7:22. 2007
    ..This permitted us to directly examine when Nodal signals specify cell types independently of dosage effects...
  64. ncbi Fgf19 is required for zebrafish lens and retina development
    Yoshiaki Nakayama
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 313:752-66. 2008
    ..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish...
  65. ncbi Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction
    Nadia Mercader
    European Molecular Biology Laboratory EMBL Heidelberg, Germany
    Development 133:2805-15. 2006
    ..tbx5 is required for Fgf signaling in the limb bud leading to activation of prdm1 expression, which in turn is required for downstream activation of fgf10 expression...
  66. pmc Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
    ..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis...
  67. ncbi The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear
    Olivier Bricaud
    Leslie and Susan Gonda Goldschmied Cell and Molecular Biology Department, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 26:10438-51. 2006
    ..Our results are the first to demonstrate a dual role for a member of the Pax-Six-Eya-Dach regulatory network in inner ear development...
  68. pmc Smad1 and Smad5 differentially regulate embryonic hematopoiesis
    Lisa J McReynolds
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 110:3881-90. 2007
    ..Our results suggest that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5...
  69. ncbi Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
    Jantje M Gerdes
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 39:1350-60. 2007
    ....
  70. doi Protocadherin-19 is essential for early steps in brain morphogenesis
    Michelle R Emond
    Center for Molecular Neurobiology and Department of Neuroscience, 115 Rightmire Hall, Ohio State University, Columbus, OH 43210, USA
    Dev Biol 334:72-83. 2009
    ..These results provide the first functional data for protocadherin-19, demonstrating an essential role in early brain development...
  71. pmc An early requirement for maternal FoxH1 during zebrafish gastrulation
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
    Dev Biol 310:10-22. 2007
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling...
  72. ncbi Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signaling
    Yann Gibert
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Konstanz, Germany
    Development 133:2649-59. 2006
    ..Thus, RA signaling from flanking somites plays a dual early role in the condensing limb bud mesenchyme...
  73. ncbi A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines
    Alexander Picker
    Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 129:3227-39. 2002
    ..1. Comparison of transgene expression in wild-type and homozygous pax2.1 mutant no isthmus (noi) embryos reveals that the transgene contains control element(s) for a novel, positive transcriptional feedback loop ..
  74. ncbi The activity of neurogenin1 is controlled by local cues in the zebrafish embryo
    P Blader
    IGBMC, CNRS INSERM ULP, Illkirch, France
    Development 124:4557-69. 1997
    ..Together these data suggest that Hh signals regulate neurogenin1 expression and subsequently modulate the type of neurons produced by Neurogenin1 activity...
  75. ncbi Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrain
    G Begemann
    Department of Biology, University of Konstanz, 78464 Constance, Germany
    Dev Biol 271:119-29. 2004
    ..In addition, blockage of RA-mediated signaling not only interferes with the differentiation of branchiomotor neurons and their axons in the hindbrain, but also affects the development of the posterior lateral line nerve...
  76. ncbi Zebrafish contains two pax6 genes involved in eye development
    S Nornes
    Department of Biochemistry, Institute of Medical Biology, University of Tromso, 903 7, Tromso, Norway
    Mech Dev 77:185-96. 1998
    ....
  77. ncbi The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
    K Gritsman
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Cell 97:121-32. 1999
    ..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development...
  78. ncbi Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:2129-40. 1999
    During the development of the zebrafish nervous system both noi, a zebrafish pax2 homolog, and ace, a zebrafish fgf8 homolog, are required for development of the midbrain and cerebellum...
  79. ncbi casanova plays an early and essential role in endoderm formation in zebrafish
    J Alexander
    Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
    Dev Biol 215:343-57. 1999
    ....
  80. ncbi nlz gene family is required for hindbrain patterning in the zebrafish
    Jacqueline Hoyle
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, USA
    Dev Dyn 229:835-46. 2004
    ..expressed in the presumptive hindbrain and midbrain/hindbrain boundary, where expression of nlz1 is dependent on pax2a. In addition, nlz2 is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon...
  81. ncbi Isolation of nlz2 and characterization of essential domains in Nlz family proteins
    Alexander P Runko
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 279:11917-25. 2004
    ..Our data demonstrate that nlz2 functions similarly to nlz1 and define conserved domains essential for nuclear localization, self-association, and corepressor binding in this novel family of zinc-finger genes...
  82. ncbi Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo
    B Thisse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, CU de Strasbourg, France
    Nature 403:425-8. 2000
    ..We propose that modulation of intercellular signalling by Antivin/Activin and Nodal-related factors provides a mechanism for the graded establishment of cell fates along the antero-posterior axis of the zebrafish embryo...
  83. ncbi Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrain
    Alexander P Runko
    Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Dev Biol 262:254-67. 2003
    ..We conclude that Nlz is a transcriptional repressor that controls segmental gene expression in the hindbrain. Lastly, we identify additional nlz-related genes, suggesting that Nlz belongs to a family of zinc-finger proteins...
  84. ncbi cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
    Alan J Davidson
    Department of Medicine, Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 425:300-6. 2003
    ..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis...
  85. ncbi Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling
    Muriel Rhinn
    Department of Genetics, Max Planck Institute for Molecular Cell Biology and Genetics, University of Dresden, Pfotenhauer Strasse 108, 01307 Dresden, Germany
    Mech Dev 120:919-36. 2003
    ..Analysis of gbx1 and gbx2 expression during formation of the MHB in mutant embryos for pax2.1, fgf8 and pou2 (noi, ace, spg), as well as Fgf-inhibition experiments, show that gbx1 acts upstream of these genes in MHB development...
  86. ncbi Zebrafish foxi1 mediates otic placode formation and jaw development
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 130:929-40. 2003
    ..In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos...
  87. ncbi Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
    Filipa Carreira-Barbosa
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:4037-46. 2003
    ..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway...
  88. ncbi Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle
    Habib Maroon
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 9RT, UK
    Development 129:2099-108. 2002
    ..We propose that Fgf3 and Fgf8 are required together for formation of the otic placode and act during the earliest stages of its induction...
  89. ncbi The function of silberblick in the positioning of the eye anlage in the zebrafish embryo
    C P Heisenberg
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Dev Biol 184:85-94. 1997
    ..These findings may therefore provide a starting point in elucidating the role of neural plate morphogenesis in positioning of the eyes...
  90. ncbi Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:179-90. 1996
    Mutations in two genes affect the formation of the boundary between midbrain and hindbrain (MHB): no isthmus (noi) and acerebellar (ace)...
  91. ncbi Ultraviolet irradiation impairs epiboly in zebrafish embryos: evidence for a microtubule-dependent mechanism of epiboly
    U Strahle
    Imperial Cancer Research Fund, Department of Zoology, Oxford, UK
    Development 119:909-19. 1993
    ....
  92. ncbi Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways
    G M Kelly
    Howard Hughes Medical Institute, Department of Pharmacology, Seattle, Washington, USA
    Development 121:1787-99. 1995
    ....
  93. ncbi Midline signalling is required for Pax gene regulation and patterning of the eyes
    R Macdonald
    Developmental Biology Research Centre, Randall Institute, Kings College London, UK
    Development 121:3267-78. 1995
    ....
  94. ncbi Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish
    L Solnica-Krezel
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:67-80. 1996
    ..These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates...
  95. ncbi Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
    S C Ekker
    Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, Baltimore, Maryland 21205, USA
    Curr Biol 5:944-55. 1995
    ..Within the neural tube, at the level of the spinal cord, products of the vertebrate gene sonic hedgehog (shh) are proposed to function as a ventral patterning influence, with the capability of inducing floor plate and motor neurons...
  96. ncbi Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafish
    P Mercier
    DIBIT, Istituto Scientifico H S Raffaele, Milan, Italy
    Int J Dev Biol 39:559-73. 1995
    ..The peculiar spatio-temporal pattern of these genes during early zebrafish gastrulation suggests a role of this gene family in interactions between anterior mesendoderm and neuroectoderm...
  97. ncbi Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryos
    Antony W Wood
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109, USA
    Mol Endocrinol 19:1024-34. 2005
    ..These findings suggest that IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism...
  98. ncbi Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish
    Chris J Thorpe
    Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, Box 357750, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 132:1763-72. 2005
    ..These data place sp5l downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish...
  99. ncbi Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
    M Hammerschmidt
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 10:647-58. 1996
    ..These results, together with epistasis studies on the block of ectopic Hh signaling by PKA*, indicate that PKA acts in target cells as a common negative regulator of Hedgehog signaling...
  100. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield...

Research Grants50

  1. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary C Mullins; Fiscal Year: 2010
    ....
  2. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2007
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  3. Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell Development
    Qin Liu; Fiscal Year: 2007
    ....
  4. GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISH
    BRUCE RILEY; Fiscal Year: 2007
    ..Therefore, achieving a fuller understanding of how the inner ear develops could eventually lead to effective medical interventions for human deafness or other disorders of the inner ear. ..
  5. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2006
    ..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
  6. A Screen For Drugs:Promote Oligodendrocyte Formatio(RMI)
    Bruce Appel; Fiscal Year: 2005
    ..Neural diseases and injuries have devastating impacts on human health. This work will provide a foundation for identifying and investigating genes and drugs that promote neural regeneration and recovery. ..
  7. Genetic analysis of male gonadal development
    Mary C Mullins; Fiscal Year: 2010
    ..Identification of the genes responsible for these defects in the zebrafish will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  8. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary C Mullins; Fiscal Year: 2010
    ....
  9. GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISH
    Bruce B Riley; Fiscal Year: 2010
    ..Using zebrafish as a model, we are investigating the functions of genes believed to regulate these processes in all vertebrates. ..
  10. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2009
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  11. Genetic and molecular dissection of hair-cell function
    Teresa Nicolson; Fiscal Year: 2009
    ..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..
  12. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    ..Thus it is critical to identify and study all the genetic players in this process. ..
  13. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  14. GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISH
    BRUCE RILEY; Fiscal Year: 2002
    ..This in turn could lead to effective medical interventions to prevent, treat, or cure disorders of the inner ear. ..
  15. Role of IRS-2 in Diabetes and Beta Cell Function
    Xueying Lin; Fiscal Year: 2003
    ..abstract_text> ..
  16. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2003
    ....