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Genomes and GenesSpecies | pax2aSummaryGene Symbol: pax2a Description: paired box gene 2a Alias: PAXZF-B, Pax-2, cb378, noi, pax-b, pax2.1, pax2a1, pax[zf-b], paxb, no isthmus protein, paired box gene 2.1, paired box homeotic gene 2a, paired box protein Pax-2a Species: zebrafish Top Publications
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Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signalingHanbing Zhong
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen University Town, Shenzhen 518055, China
Mol Biosyst 5:1356-60. 2009..Together, 3F8 and its derivatives could be useful as new reagents and potential therapeutic candidates for GSK3 related diseases...
Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4aCarmen Gloria Feijóo
Center for Genomics of the Cell, Universidad de Chile, Santiago, Chile
Mol Cell Neurosci 40:328-37. 2009..Our results point to irx4a as a critical gene for numerous developmental processes and highlight its role in the formation of placodal derivatives in vertebrates...- Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activityJovica Ninkovic
Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
Development 135:3137-48. 2008..Together, our results suggest a model in which the modulation of E(Spl) and Gsk3beta/PKA activities by Gli1 underlies the dynamic properties of IZ maintenance and recruitment... - An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexesChunmei Li
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
PLoS Genet 4:e1000044. 2008..Our findings therefore implicate MIP-T3 in a previously unknown but critical role in cilium biogenesis and further highlight the emerging role of this organelle in vertebrate development... 
The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesionSophia von der Hardt
Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
Curr Biol 17:475-87. 2007....- Zebrafish cone-rod (crx) homeobox gene promotes retinogenesisYu chi Shen
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
Dev Biol 269:237-51. 2004..These results suggest novel functions for zebrafish crx during retinal specification and differentiation... - Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independentShun Kuo Sun
Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
Dev Biol 303:675-86. 2007.... - The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axisJennifer A Tucker
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Dev Cell 14:108-19. 2008..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously... - dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activityRobert Esterberg
Department of Biology, Emory University, Atlanta, GA 30322, USA
Dev Biol 325:189-99. 2009..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction... - Identification of a novel retinoid by small molecule screening with zebrafish embryosChetana Sachidanandan
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
PLoS ONE 3:e1947. 2008.... - Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalonSteffen Scholpp
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Development 130:4881-93. 2003..This provides an example of a mechanism needed to maintain the subdivision of the anterior neural plate into forebrain and midbrain... - The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesisShawn Burgess
Massachusetts Institute of Technology, Center for Cancer Research, E17 340, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Development 129:905-16. 2002.... - Regulatory gene expression patterns reveal transverse and longitudinal subdivisions of the embryonic zebrafish forebrainG Hauptmann
Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
Mech Dev 91:105-18. 2000..Our data suggest a strong conservation of early forebrain organization between lower and higher vertebrates... - Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closureJacob D Brown
Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:1462-7. 2009..We also identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure... - A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryosS Krauss
Molecular Embryology Laboratory, Imperial Cancer Research Fund, Oxford, England
Cell 75:1431-44. 1993..By expressing shh in transgenic Drosophila embryos, we also demonstrate a strong functional conservation between the fish and fly hh genes... - Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factorsStefan Hans
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
Development 131:5091-102. 2004..cells respond to Fgf signals from adjacent tissues and express two highly related paired box transcription factors Pax2a and Pax8 in the developing placode... - Isolation of nlz2 and characterization of essential domains in Nlz family proteinsAlexander P Runko
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 279:11917-25. 2004..Our data demonstrate that nlz2 functions similarly to nlz1 and define conserved domains essential for nuclear localization, self-association, and corepressor binding in this novel family of zinc-finger genes... - vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafishRafael E Hernandez
Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
Development 131:4511-20. 2004..The different requirements for vhnf1 and val to repress hoxb1a and ephrin-B2a, respectively, demonstrate that not all aspects of an individual rhombomere's identity are regulated coordinately... - Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrainG Begemann
Department of Biology, University of Konstanz, 78464 Constance, Germany
Dev Biol 271:119-29. 2004..In addition, blockage of RA-mediated signaling not only interferes with the differentiation of branchiomotor neurons and their axons in the hindbrain, but also affects the development of the posterior lateral line nerve... - Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb inductionNadia Mercader
European Molecular Biology Laboratory EMBL Heidelberg, Germany
Development 133:2805-15. 2006..tbx5 is required for Fgf signaling in the limb bud leading to activation of prdm1 expression, which in turn is required for downstream activation of fgf10 expression... - Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergenceJianfeng Zhou
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 3:e3926. 2008..Elevated expression of IGFBP-2 is often associated with progression of many types of cancers... - nlz gene family is required for hindbrain patterning in the zebrafishJacqueline Hoyle
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, USA
Dev Dyn 229:835-46. 2004..expressed in the presumptive hindbrain and midbrain/hindbrain boundary, where expression of nlz1 is dependent on pax2a. In addition, nlz2 is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon... - The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerioP Haffter
Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
Development 123:1-36. 1996..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish... - Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain developmentRafael E Hernandez
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
Development 134:177-87. 2007..We present a ;gradient-free' model for hindbrain patterning in which differential RA responsiveness along the hindbrain anterior-posterior axis is shaped primarily by the dynamic expression of RA-degrading enzymes... - Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryosAntony W Wood
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109, USA
Mol Endocrinol 19:1024-34. 2005..These findings suggest that IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism... - The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signalingAtsushi Kawakami
Department of Biological Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Curr Biol 15:480-8. 2005..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites... - The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner earOlivier Bricaud
Leslie and Susan Gonda Goldschmied Cell and Molecular Biology Department, House Ear Institute, Los Angeles, California 90057, USA
J Neurosci 26:10438-51. 2006..Our results are the first to demonstrate a dual role for a member of the Pax-Six-Eya-Dach regulatory network in inner ear development... - Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundariesTimothy Erickson
Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton AB, Canada T6G2E9
Dev Biol 301:504-17. 2007..Embryos lacking Pbx function correctly initiate midbrain patterning, but fail to maintain eng2a, pax2a, fgf8, gbx2, and wnt1 expression at the MHB... - Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signalingYann Gibert
Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Konstanz, Germany
Development 133:2649-59. 2006..Thus, RA signaling from flanking somites plays a dual early role in the condensing limb bud mesenchyme... - Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivoDiana M Ho
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
Dev Biol 295:730-42. 2006..The combination of the ALK inhibitor SB-431542 with inhibitor-resistant ALKs provides a powerful set of tools for examining nodal/activin signaling during embryogenesis... - Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafishEngda G Hagos
Department of Cellular Biology, The University of Georgia, Athens, GA, USA
BMC Dev Biol 7:22. 2007..This permitted us to directly examine when Nodal signals specify cell types independently of dosage effects... - An early requirement for maternal FoxH1 during zebrafish gastrulationWuhong Pei
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
Dev Biol 310:10-22. 2007..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling... - Smad1 and Smad5 differentially regulate embryonic hematopoiesisLisa J McReynolds
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 110:3881-90. 2007..Our results suggest that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5... - Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt responseJantje M Gerdes
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 39:1350-60. 2007.... - Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismPaul B Yu
Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Chem Biol 4:33-41. 2008..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis... - Fgf19 is required for zebrafish lens and retina developmentYoshiaki Nakayama
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
Dev Biol 313:752-66. 2008..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish... - Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acidLisa Maves
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Dev Biol 285:593-605. 2005..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities... - Cadmium inhibits neurogenesis in zebrafish embryonic brain developmentElly Suk Hen Chow
Division of Biology, California Institute of Technology, 1200 California Boulevard, Pasadena, CA 91125, USA
Aquat Toxicol 87:157-69. 2008..Our data suggest that cadmium-induced neurotoxicity can be caused by impaired neurogenesis, resulting in markedly reduced neuronal differentiation and axonogenesis... - Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafishChris J Thorpe
Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, Box 357750, University of Washington School of Medicine, Seattle, WA 98195, USA
Development 132:1763-72. 2005..These data place sp5l downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish... - Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrainAlexander P Runko
Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01605, USA
Dev Biol 262:254-67. 2003..We conclude that Nlz is a transcriptional repressor that controls segmental gene expression in the hindbrain. Lastly, we identify additional nlz-related genes, suggesting that Nlz belongs to a family of zinc-finger proteins... - cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genesAlan J Davidson
Department of Medicine, Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Nature 425:300-6. 2003..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis... - Patterning activities of vertebrate hedgehog proteins in the developing eye and brainS C Ekker
Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, Baltimore, Maryland 21205, USA
Curr Biol 5:944-55. 1995..Within the neural tube, at the level of the spinal cord, products of the vertebrate gene sonic hedgehog (shh) are proposed to function as a ventral patterning influence, with the capability of inducing floor plate and motor neurons... - Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS developmentC P Heisenberg
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Development 126:2129-40. 1999During the development of the zebrafish nervous system both noi, a zebrafish pax2 homolog, and ace, a zebrafish fgf8 homolog, are required for development of the midbrain and cerebellum... - The EGF-CFC protein one-eyed pinhead is essential for nodal signalingK Gritsman
Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Cell 97:121-32. 1999..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development... - Zebrafish contains two pax6 genes involved in eye developmentS Nornes
Department of Biochemistry, Institute of Medical Biology, University of Tromso, 903 7, Tromso, Norway
Mech Dev 77:185-96. 1998.... - A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundaryK Lun
Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
Development 125:3049-62. 1998..Mutations in the zebrafish no isthmus (noi) gene alter development of the MHB, and affect the pax2.1 gene (formerly pax(zf-b))... - The activity of neurogenin1 is controlled by local cues in the zebrafish embryoP Blader
IGBMC, CNRS INSERM ULP, Illkirch, France
Development 124:4557-69. 1997..Together these data suggest that Hh signals regulate neurogenin1 expression and subsequently modulate the type of neurons produced by Neurogenin1 activity... - The function of silberblick in the positioning of the eye anlage in the zebrafish embryoC P Heisenberg
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Dev Biol 184:85-94. 1997..These findings may therefore provide a starting point in elucidating the role of neural plate morphogenesis in positioning of the eyes... - Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrainM Brand
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Development 123:179-90. 1996Mutations in two genes affect the formation of the boundary between midbrain and hindbrain (MHB): no isthmus (noi) and acerebellar (ace)... - Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genesM C Mullins
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Development 123:81-93. 1996..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield... - Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafishL Solnica-Krezel
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:67-80. 1996..These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates... - Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafishP Mercier
DIBIT, Istituto Scientifico H S Raffaele, Milan, Italy
Int J Dev Biol 39:559-73. 1995..The peculiar spatio-temporal pattern of these genes during early zebrafish gastrulation suggests a role of this gene family in interactions between anterior mesendoderm and neuroectoderm... - Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryoM Hammerschmidt
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 10:647-58. 1996..These results, together with epistasis studies on the block of ectopic Hh signaling by PKA*, indicate that PKA acts in target cells as a common negative regulator of Hedgehog signaling... - Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryosU Strahle
Department of Zoology, Molecular Embryology Laboratory and Developmental Genetics Laboratory, University of Oxford, UK
Genes Dev 7:1436-46. 1993..Taken together, our data suggest that Axial plays a crucial role in specification of both the axial mesendoderm and the ventral central nervous system... - Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathwaysG M Kelly
Howard Hughes Medical Institute, Department of Pharmacology, Seattle, Washington, USA
Development 121:1787-99. 1995.... - Midline signalling is required for Pax gene regulation and patterning of the eyesR Macdonald
Developmental Biology Research Centre, Randall Institute, Kings College London, UK
Development 121:3267-78. 1995.... - casanova plays an early and essential role in endoderm formation in zebrafishJ Alexander
Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
Dev Biol 215:343-57. 1999.... - Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryoB Thisse
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, CU de Strasbourg, France
Nature 403:425-8. 2000..We propose that modulation of intercellular signalling by Antivin/Activin and Nodal-related factors provides a mechanism for the graded establishment of cell fates along the antero-posterior axis of the zebrafish embryo... - A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic linesAlexander Picker
Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Pfotenhauerstr 108, 01307 Dresden, Germany
Development 129:3227-39. 2002..1. Comparison of transgene expression in wild-type and homozygous pax2.1 mutant no isthmus (noi) embryos reveals that the transgene contains control element(s) for a novel, positive transcriptional feedback loop .. - Increased Hox activity mimics the teratogenic effects of excess retinoic acid signalingJoshua S Waxman
Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Dev Dyn 238:1207-13. 2009..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart... - Ultraviolet irradiation impairs epiboly in zebrafish embryos: evidence for a microtubule-dependent mechanism of epibolyU Strahle
Imperial Cancer Research Fund, Department of Zoology, Oxford, UK
Development 119:909-19. 1993.... - Zebrafish foxi1 mediates otic placode formation and jaw developmentKeely S Solomon
Department of Biology, Emory University, Atlanta, GA 30322, USA
Development 130:929-40. 2003..In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos... - Fgf3 and Fgf8 are required together for formation of the otic placode and vesicleHabib Maroon
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 9RT, UK
Development 129:2099-108. 2002..We propose that Fgf3 and Fgf8 are required together for formation of the otic placode and act during the earliest stages of its induction... - Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafishFilipa Carreira-Barbosa
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Development 130:4037-46. 2003..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway... - Protocadherin-19 is essential for early steps in brain morphogenesisMichelle R Emond
Center for Molecular Neurobiology and Department of Neuroscience, 115 Rightmire Hall, Ohio State University, Columbus, OH 43210, USA
Dev Biol 334:72-83. 2009..These results provide the first functional data for protocadherin-19, demonstrating an essential role in early brain development... - Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signalingMuriel Rhinn
Department of Genetics, Max Planck Institute for Molecular Cell Biology and Genetics, University of Dresden, Pfotenhauer Strasse 108, 01307 Dresden, Germany
Mech Dev 120:919-36. 2003..Analysis of gbx1 and gbx2 expression during formation of the MHB in mutant embryos for pax2.1, fgf8 and pou2 (noi, ace, spg), as well as Fgf-inhibition experiments, show that gbx1 acts upstream of these genes in MHB development... - A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and developmentGang Lu
Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 21:784-96. 2007..These data suggest that PP2Cm is a novel mitochondrial protein phosphatase that has a critical function in cell death and survival, and may play a role in regulating the MPTP opening... - Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic responseAnirban Chakraborty
Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
PLoS ONE 4:e4152. 2009..These results suggest that ribosomal dysfunction due to the loss of L11 activates a p53-dependent checkpoint response to prevent improper embryonic development... - Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfindingHeike Diekmann
Department of Biology, Universitat Konstanz, Konstanz, Germany
J Comp Neurol 513:38-50. 2009..Without Neurolin-b, RGC axons grow in highly aberrant routes along the optic tract and/or fail to reach the optic tectum. Thus, the zebrafish Neurolin paralogs are involved in distinct steps of retinotectal development... - RNA profiling of FAC-sorted neurons from the developing zebrafish spinal cordGustavo A Cerda
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
Dev Dyn 238:150-61. 2009..This protocol for dissociating, sorting and RNA-profiling neurons from organogenesis-stage zebrafish embryos should also be applicable to other developing organs and tissues and potentially other model organisms... - MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundaryChristoph Leucht
Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
Nat Neurosci 11:641-8. 2008..Together, these findings highlight a previously unknown mechanism by which a single microRNA fine-tunes late MHB coherence via its co-regulation of patterning activities and neurogenesis... - odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fateSudha P Mudumana
Nephrology Division, Massachusetts General Hospital, Charlestown, MA 02129, USA
Development 135:3355-67. 2008.... - Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafishMaria Vega C Flores
Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Nat Cell Biol 10:346-52. 2008.... - Selective interaction between Trf3 and Taf3 required for early development and hematopoiesisDaniel O Hart
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Dev Dyn 238:2540-9. 2009..Thus, a selective interaction between Trf3 and Taf3 is required for early zebrafish development and initiation of hematopoiesis. Finally, we provide evidence that TRF3 and TAF3 are also required for hematopoiesis initiation in the mouse... - Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafishChisako Nakada
Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
J Exp Zool B Mol Dev Evol 312:827-40. 2009..Furthermore, the roles reported for FOXE1 in mammalian thyroid development may have been acquired during evolution... - Hgf/c-met expression and functional analysis during zebrafish embryogenesisAndrew J Latimer
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Dev Dyn 237:3904-15. 2008..Similar to mouse, knockdown of zebrafish Met reduces liver size. Our results suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish... - Regulation and function of Dbx genes in the zebrafish spinal cordSuzanna L Gribble
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132 3401, USA
Dev Dyn 236:3472-83. 2007..Our data confirm that the dbx1a/1b/2 domain in zebrafish spinal cord development behaves similarly to amniotes, while extending knowledge of Dbx1 function in spinal cord patterning... - Zebrafish twist1 is expressed in craniofacial, vertebral, and renal precursorsGare Hoon Yeo
Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Dev Genes Evol 217:783-9. 2007..At the 24-hpf stage, twist1 transcripts were also observed in the ventral tail-bud region. These observations are consistent with a role for twist1 in craniofacial, vertebral, and early renal development... - Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate developmentPing Ke Fang
Urological Diseases Research Center, Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Enders Research Laboratories, Suite 1161, 300 Longwood Ave, Boston, MA 02115, USA
Am J Pathol 169:2209-22. 2006..Cav-1alpha and -1beta morphants also exhibited disruption in the actin cytoskeleton. These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis... - Role of the hindbrain in patterning the otic vesicle: a study of the zebrafish vhnf1 mutantVirginie Lecaudey
Unite de Biologie du Developpement, CNRS UMR 7622, Universite Pierre et Marie Curie, Paris, France
Dev Biol 303:134-43. 2007..They suggest that, despite the evolution of inner ear structure and function, some of the mechanisms underlying the regionalisation of the otic vesicle in fish and amniotes have been conserved... - Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafishMin Jung Kim
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
Glycobiology 17:231-47. 2007..Together these results show that agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish... - Otopetrin 1 is required for otolith formation in the zebrafish Danio rerioInna Hughes
Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
Dev Biol 276:391-402. 2004..These studies demonstrate that Otop1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith... - Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterningShawn C Little
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
Development 131:5825-35. 2004..Our results support a model in which zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning... - An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterningJustin Gage Crump
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Development 131:5703-16. 2004..Moreover, we argue that the Fgf-dependent morphogenesis of the pharyngeal endoderm into pouches is critical for the later patterning of pharyngeal cartilages... - Conservation of structure and functional divergence of duplicated Wnt8s in pufferfishMarie Christine Ramel
Department of Biology, Texas A and M University, 3258 TAMU, College Station, Texas 77843 3258, USA
Dev Dyn 231:441-8. 2004..This finding suggests that zebrafish (and possibly teleost in general) Wnt8 receptors are able to discriminate between highly related ligands... - Repression of the vertebrate organizer by Wnt8 is mediated by Vent and VoxMarie Christine Ramel
Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
Development 131:3991-4000. 2004..Thus, whereas both Wnt8 and zygotic BMP are ventralizing agents that regulate common target genes, their temporally different modes of action are necessary to pattern the embryo harmoniously along its DV axis... - The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrainVirginie Lecaudey
Unité de Biologie moléculaire du Développement, Unité INSERM 368, Ecole Normale Superieure, 46, rue d Ulm, 75005 Paris, France
Development 131:3121-31. 2004..We propose that iro7 has a dual function in the hindbrain of the zebrafish embryo: it is required for the proper positioning of the prospective r4/r5 boundary and it promotes neurogenesis in the anterior hindbrain... - Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formationGerri R Buckles
Department of Biology, Texas A and M University, 3258 TAMU, College Station, TX 77843 3258, USA
Mech Dev 121:437-47. 2004..In zebrafish embryos lacking Wnt3a, Wnt1 and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 is not maintained after mid-somitogenesis... - Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfishPing Liang
Department of Cancer Genetics and of Cancer Prevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Physiol Genomics 16:314-22. 2004.... - Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plateAlexandra Tallafuss
Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Munich, Germany
Dev Dyn 227:524-35. 2003..Together, our results suggest that a combination of patterning-related and -unrelated mechanisms specifically controls the size of individual early neuronal clusters within the anterior neural plate... - The zebrafish annexin gene familySteven A Farber
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Genome Res 13:1082-96. 2003..The differences in gene expression of recently duplicated anx genes could explain why highly related paralogs were maintained in the genome and did not rapidly become pseudogenes... - N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neuritesIchiro Masai
Masai Initiative Research Unit, The Institute of Physical and Chemical Research RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
Development 130:2479-94. 2003..Although in vitro studies have implicated Fgf receptors in modulating the axon outgrowth promoting properties of Ncad, most aspects of the Ncad mutant phenotype are not phenocopied by treatments that block Fgf receptor function... - Developmental expression of zebrafish emx1 during early embryogenesisAtsuo Kawahara
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Gene Expr Patterns 2:201-6. 2002..Thus, emx1 displays a unique expression pattern that is distinct from the patterns of emx2 and emx3... - Cadherin-17 is required to maintain pronephric duct integrity during zebrafish developmentJulia Horsfield
Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
Mech Dev 115:15-26. 2002..This finding contrasts with the role of mammalian CDH17, which does not appear to be involved in nephric development... - Expression pattern of the frizzled 7 gene during zebrafish embryonic developmentS El-Messaoudi
Institut de Genetique Humaine, 141 rue de la Cardonille, 34033, Montpellier, France
Mech Dev 102:231-4. 2001..The strong sequence conservation of fz7 to the mouse, chick and Xenopus counterparts is also true for their expression pattern... - Differential regulation of chordin expression domains in mutant zebrafishV E Miller-Bertoglio
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Dev Biol 192:537-50. 1997..1989), while axial mesodermal expression was affected. This finding reveals an unexpected function for spadetail in midline mesoderm and in differential regulation of chordin expression during gastrulation... - dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurulaTakao Kaji
Department of Craniofacial Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Dev Biol 276:523-40. 2004..These data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via BMP activity... - Wnt4 affects morphogenesis when misexpressed in the zebrafish embryoA R Ungar
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195, USA
Mech Dev 52:153-64. 1995..Our data suggest that wnt4, like Xwnt-5A, inhibits cell movements, and that these Wnts define a functional class distinct from the class which includes Wnt-1, Xwnt-3A and Xwnt-8... - Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryoAndrea Isken
Department of Neurobiology, Institute of Biology I, Albert Ludwigs University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
J Biol Chem 282:1144-51. 2007.... - Role of two genes encoding PACAP in early brain development in zebrafishSheng Wu
Department of Biology, University of Victoria, 3800 Finnerty Road, Victoria, B C V8W 3N5, Canada
Ann N Y Acad Sci 1070:602-21. 2006..The early expression of transcripts for PACAP and its receptors by 0.5-6 hpf make both PACAP1 and PACAP2 candidates for factors that influence brain development... - Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonistsGang Peng
Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
Development 133:3191-200. 2006..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists...
Research Grants
- DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYOMary C Mullins; Fiscal Year: 2010....
- Genetic analysis of ovary development and oogenesisMary Mullins; Fiscal Year: 2007..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
- Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell DevelopmentQin Liu; Fiscal Year: 2007....
- GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISHBRUCE RILEY; Fiscal Year: 2007..Therefore, achieving a fuller understanding of how the inner ear develops could eventually lead to effective medical interventions for human deafness or other disorders of the inner ear. ..
- DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYOMary Mullins; Fiscal Year: 2006..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
- A Screen For Drugs:Promote Oligodendrocyte Formatio(RMI)Bruce Appel; Fiscal Year: 2005..Neural diseases and injuries have devastating impacts on human health. This work will provide a foundation for identifying and investigating genes and drugs that promote neural regeneration and recovery. ..
- Genetic analysis of male gonadal developmentMary C Mullins; Fiscal Year: 2010..Identification of the genes responsible for these defects in the zebrafish will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
- DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYOMary C Mullins; Fiscal Year: 2010....
- GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISHBruce B Riley; Fiscal Year: 2010..Using zebrafish as a model, we are investigating the functions of genes believed to regulate these processes in all vertebrates. ..
- Genetic analysis of ovary development and oogenesisMary Mullins; Fiscal Year: 2009..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
- Genetic and molecular dissection of hair-cell functionTeresa Nicolson; Fiscal Year: 2009..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..
- DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYOMary Mullins; Fiscal Year: 2007..Thus it is critical to identify and study all the genetic players in this process. ..
- Genetic Analysis of Maternal Factors in Embryonic Devel*Mary Mullins; Fiscal Year: 2005..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
- GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISHBRUCE RILEY; Fiscal Year: 2002..This in turn could lead to effective medical interventions to prevent, treat, or cure disorders of the inner ear. ..
- Role of IRS-2 in Diabetes and Beta Cell FunctionXueying Lin; Fiscal Year: 2003..abstract_text> ..
- DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYOMary Mullins; Fiscal Year: 2003....