Gene Symbol: pappaa
Description: pregnancy-associated plasma protein A, pappalysin 1a
Alias: pappalysin-1, papp-a', unfiltered
Species: zebrafish
Products:     pappaa

Top Publications

  1. Kjaer Sorensen K, Engholm D, Kamei H, Morch M, Kristensen A, Zhou J, et al. Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity. J Biol Chem. 2013;288:9982-92 pubmed publisher
    ..We conclude that Papp-a possesses biological functions independent of its proteolytic activity. Our data represent the first evidence for a non-proteolytic function of PAPP-A. ..
  2. Wolman M, Jain R, Marsden K, Bell H, Skinner J, Hayer K, et al. A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning. Neuron. 2015;85:1200-11 pubmed publisher
    ..habituation mutants including mutants of the vertebrate-specific gene pregnancy-associated plasma protein-aa (pappaa)...
  3. Giousoh A, Vaz R, Bryson Richardson R, Whisstock J, Verkade H, Bird P. Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Gene Expr Patterns. 2015;18:37-43 pubmed publisher
  4. Sugden W, Meissner R, Aegerter Wilmsen T, Tsaryk R, Leonard E, Bussmann J, et al. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017;19:653-665 pubmed publisher
    ..Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs. ..