Gene Symbol: panx1a
Description: pannexin 1a
Alias: panx1, zgc:55631, pannexin-1, pannexin 1
Zoidl G, Kremer M, Zoidl C, Bunse S, Dermietzel R. Molecular diversity of connexin and pannexin genes in the retina of the zebrafish Danio rerio. Cell Commun Adhes. 2008;15:169-83 pubmed publisher
..This result demonstrates the presence of two distinct gap junction type gene families and indicates a remarkable molecular and functional diversity of gap junction-mediated coupling in the fish retina. ..
Prochnow N, Hoffmann S, Vroman R, Klooster J, Bunse S, Kamermans M, et al
. Pannexin1 in the outer retina of the zebrafish, Danio rerio. Neuroscience. 2009;162:1039-54 pubmed publisher
..mutation of a single amino acid within a conserved protein motif recently shown to be N-glycosylated in rodent Panx1. Together, these findings indicate that zfPanx1 displays properties similar to its mammalian homologues and can ..
Prochnow N, Hoffmann S, Dermietzel R, Zoidl G. Replacement of a single cysteine in the fourth transmembrane region of zebrafish pannexin 1 alters hemichannel gating behavior. Exp Brain Res. 2009;199:255-64 pubmed publisher
Pannexin1 (Panx1) is a novel candidate for an electrical synapse protein in the retina. At present Panx1 is considered to function as a hemichannel...
Bond S, Wang N, Leybaert L, Naus C. Pannexin 1 ohnologs in the teleost lineage. J Membr Biol. 2012;245:483-93 pubmed
..results indicate that both copies of the ancestral teleost panx1 gene were conserved following the last whole-genome duplication event and, following conventional zebrafish nomenclature, should now be referred to as panx1a and panx1b.
Kurtenbach S, Prochnow N, Kurtenbach S, Klooster J, Zoidl C, Dermietzel R, et al
. Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS ONE. 2013;8:e77722 pubmed publisher
In mammals, a single pannexin1 gene (Panx1) is widely expressed in the CNS including the inner and outer retinae, forming large-pore voltage-gated membrane channels, which are involved in calcium and ATP signaling...
Li Y, Du X, Liu C, Wen Z, Du J. Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev Cell. 2012;23:1189-202 pubmed publisher
..Our findings reveal an instructive role for neuronal activity in resting microglial motility and suggest the function for microglia in homeostatic regulation of neuronal activity in the healthy brain. ..
Vroman R, Klaassen L, Howlett M, Cenedese V, Klooster J, Sjoerdsma T, et al
. Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft. PLoS Biol. 2014;12:e1001864 pubmed publisher
..The second one is a relatively slow (??200 ms), highly intriguing mechanism. It depends on ATP release via Pannexin 1 channels located on horizontal cell dendrites invaginating the cone synaptic terminal...
De Boer T, van der Heyden M. Xenopus connexins: how frogs bridge the gap. Differentiation. 2005;73:330-40 pubmed
..We compare Xenopus Cxs with those of zebrafish and mouse, and provide evidence for the existence of several additional, non-identified, amphibian Cxs. Finally, we identify two new Xenopus pannexins by screening EST libraries. ..
Iovine M, Gumpert A, Falk M, Mendelson T. Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. FEBS Lett. 2008;582:165-70 pubmed
..Functional assays reveal that the Cx23 gap junctions are capable of sharing neurobiotin, and further, that Cx23 connexins form hemichannels in vitro. ..