Gene Symbol: pak2b
Description: p21 protein (Cdc42/Rac)-activated kinase 2b
Alias: CH73-159L23.1, wu:fc52b03, zgc:113857, serine/threonine-protein kinase PAK 2, p21 (CDKN1A)-activated kinase 2b
Species: zebrafish

Top Publications

  1. Buchner D, Su F, Yamaoka J, Kamei M, Shavit J, Barthel L, et al. pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci U S A. 2007;104:13996-4001 pubmed
    ..Reduced expression of another PAK2 ortholog, pak2b, in Pak2a-deficient embryos results in a more severe hemorrhagic phenotype, consistent with partially overlapping ..
  2. Liu J, Fraser S, Faloon P, Rollins E, Vom Berg J, Starovic Subota O, et al. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci U S A. 2007;104:13990-5 pubmed
    ..These data identify an essential in vivo role for betaPix and Pak2a during embryonic development and illuminate a previously unrecognized pathway specifically involved in cerebrovascular stabilization. ..
  3. Tay H, Ng Y, Manser E. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS ONE. 2010;5:e10125 pubmed publisher
    ..These events may mirror the requirement for PAK2 signaling essential for the proper formation of the blood-brain barrier. ..
  4. Law S, Sargent T. Maternal pak4 expression is required for primitive myelopoiesis in zebrafish. Mech Dev. 2013;130:181-94 pubmed publisher
  5. Kovács R, Csenki Z, Bakos K, Urbányi B, Horváth Ã, Garaj Vrhovac V, et al. Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Water Res. 2015;77:201-212 pubmed publisher