Gene Symbol: pak2a
Description: p21 protein (Cdc42/Rac)-activated kinase 2a
Alias: cb422, kinase, pak2, si:dz198m22.1, wu:fb71h01, zgc:91798, serine/threonine-protein kinase PAK 2, p21 (CDKN1A)-activated kinase 2, p21 (CDKN1A)-activated kinase 2a, p21-activated kinase 2, redhead, rhd
Species: zebrafish

Top Publications

  1. Chen J, Ruan H, Ng S, Gao C, Soo H, Wu W, et al. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev. 2005;19:2900-11 pubmed
  2. Liu J, Fraser S, Faloon P, Rollins E, Vom Berg J, Starovic Subota O, et al. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci U S A. 2007;104:13990-5 pubmed
    ..Positional cloning of bbh reveals a hypomorphic mutation in betaPix, a binding partner for the p21-activated kinase (Pak) and a guanine nucleotide exchange factor for Rac and Cdc42...
  3. Buchner D, Su F, Yamaoka J, Kamei M, Shavit J, Barthel L, et al. pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci U S A. 2007;104:13996-4001 pubmed
    ..Here, we identify a zebrafish mutant, redhead (rhd(mi149)), that exhibits embryonic CNS hemorrhage with intact gross development of the vasculature and normal ..
  4. Fent K, Chew G, Li J, Gomez E. Benzotriazole UV-stabilizers and benzotriazole: Antiandrogenic activity in vitro and activation of aryl hydrocarbon receptor pathway in zebrafish eleuthero-embryos. Sci Total Environ. 2014;482-483:125-36 pubmed publisher
    ..Forthcoming studies should show whether the observed antiandrogenic activities and transcriptional changes translate into physiological effects . ..
  5. Berghmans S, Murphey R, Wienholds E, Neuberg D, Kutok J, Fletcher C, et al. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A. 2005;102:407-12 pubmed
  6. Lim C, Chong S, Jiang Y. Udu deficiency activates DNA damage checkpoint. Mol Biol Cell. 2009;20:4183-93 pubmed publisher
    ..Furthermore, Udu is colocalized with 5-bromo-2'-deoxyuridine and heterochromatin during DNA replication, suggesting a role in maintaining genome integrity. ..
  7. Law S, Sargent T. Maternal pak4 expression is required for primitive myelopoiesis in zebrafish. Mech Dev. 2013;130:181-94 pubmed publisher
    Transcripts of pak4, the zebrafish ortholog of p21-activated kinase 4 (PAK4), are most abundant in the egg and fall to low levels by the end of gastrulation, after which expression is essentially ubiquitous...
  8. Jeon H, Lee H. Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. FEBS J. 2013;280:1518-30 pubmed publisher
    Aurora-A is a serine/threonine mitotic kinase that is required for centrosome maturation. Many cancer cells over-express Aurora-A, and several reports have suggested that Aurora-A has prognostic value in the clinical treatment of cancer...
  9. Christen V, Capelle M, Fent K. Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish. Toxicol Appl Pharmacol. 2013;272:519-28 pubmed publisher
    ..Our data demonstrate for the first time that AgNPs lead to induction of ER stress in zebrafish. The induction of ER stress can have several consequences including the activation of apoptotic and inflammatory pathways...

More Information


  1. Choi J, Kim S, Ahn J, Youn P, Kang J, Park K, et al. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish. Aquat Toxicol. 2010;100:151-9 pubmed publisher
    ..In addition, the p53-related pro-apoptotic genes Bax, Noxa, and p21 were upregulated after treatment with AgNPs. These data suggest that oxidative stress and apoptosis are associated with AgNP toxicity in the liver of adult zebrafish. ..
  2. Tay H, Ng Y, Manser E. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS ONE. 2010;5:e10125 pubmed publisher
    ..This new signaling pathway involves activation of an effector kinase PAK, and involvement of the adaptor PAK-interacting exchange factor PIX...
  3. Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
    ..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
  4. Choe C, Crump J. Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics. Development. 2015;142:1089-94 pubmed publisher
    ..Here, we report novel requirements for the EphrinB ligands B2a and B3b, the Ephb4a receptor and the Pak2a kinase in the development of pouches and the posterior facial skeleton that depends on pouches for its segmentation...
  5. Gore A, Lampugnani M, Dye L, Dejana E, Weinstein B. Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Dis Model Mech. 2008;1:275-81 pubmed publisher
    ..These findings support the idea that minor polygenic deficits in the CCM pathway can strongly synergize to initiate ICH. ..
  6. Huang L, Wang C, Zhang Y, Li J, Zhong Y, Zhou Y, et al. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos. Chemosphere. 2012;87:369-75 pubmed publisher
    ..The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating B(a)P-mediated cardiovascular defects and consequences. ..