Gene Symbol: pak1
Description: p21 protein (Cdc42/Rac)-activated kinase 1
Alias: cb761, wu:fj97h10, serine/threonine-protein kinase PAK 1, p21/Cdc42/Rac1-activated kinase 1
Species: zebrafish
Products:     pak1

Top Publications

  1. Liu J, Fraser S, Faloon P, Rollins E, Vom Berg J, Starovic Subota O, et al. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci U S A. 2007;104:13990-5 pubmed
    ..These data identify an essential in vivo role for betaPix and Pak2a during embryonic development and illuminate a previously unrecognized pathway specifically involved in cerebrovascular stabilization. ..
  2. Veldman M, Bemben M, Thompson R, Goldman D. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Dev Biol. 2007;312:596-612 pubmed
    ..These results implicate KLF6a and KLF7a as important mediators of optic nerve regeneration and suggest that not all induced genes are essential to mount a regenerative response. ..
  3. Tay H, Ng Y, Manser E. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS ONE. 2010;5:e10125 pubmed publisher
    ..These events may mirror the requirement for PAK2 signaling essential for the proper formation of the blood-brain barrier. ..
  4. Zou J, Li W, Li Q, Li X, Zhang J, Liu G, et al. Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish. Circ Res. 2011;108:201-9 pubmed publisher
    ..p21-activated kinase1 (pak1) was identified as a novel target of miR-126a/b, and pak1 3' untranslated region was differently regulated by these ..
  5. Law S, Sargent T. Maternal pak4 expression is required for primitive myelopoiesis in zebrafish. Mech Dev. 2013;130:181-94 pubmed publisher
  6. Magini P, Pippucci T, Tsai I, Coppola S, Stellacci E, Bartoletti Stella A, et al. A mutation in PAK3 with a dual molecular effect deregulates the RAS/MAPK pathway and drives an X-linked syndromic phenotype. Hum Mol Genet. 2014;23:3607-17 pubmed publisher
  7. Kelly M, Astsaturov A, Rhodes J, Chernoff J. A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Dev Cell. 2014;29:350-9 pubmed publisher
    ..processes in vertebrates, is regulated in the developing neural crest by p21-activated protein kinase 1 (Pak1)...
  8. Lightcap C, Kari G, Arias Romero L, Chernoff J, Rodeck U, Williams J. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS ONE. 2009;4:e6025 pubmed publisher
    b>Pak1 (p21 activated kinase 1) is a serine/threonine kinase implicated in regulation of cell motility and survival and in malignant transformation of mammary epithelial cells...