otx2a

Summary

Gene Symbol: otx2a
Description: orthodenticle homeobox 2a
Alias: otx1a, otx1l, otx3, homeobox protein OTX1 A, homeobox protein Otx1l, orthodenticle homeobox 1a, orthodenticle homolog 1 like, orthodenticle homolog 1a, orthodenticle homolog 3, zOTX3
Species: zebrafish

Top Publications

  1. Scholpp S, Foucher I, Staudt N, Peukert D, Lumsden A, Houart C. Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development. 2007;134:3167-76 pubmed
    ..Here we show that, before ZLI formation, both Otx1l and Otx2 (collectively referred to as Otx1l/2) are expressed in spatially restricted domains...
  2. Hauptmann G, Söll I, Gerster T. The early embryonic zebrafish forebrain is subdivided into molecularly distinct transverse and longitudinal domains. Brain Res Bull. 2002;57:371-5 pubmed
    ..Furthermore, we identified a series of eight transverse diencephalic domains which may indicate a prosomeric organization of the rostral zebrafish brain. ..
  3. Foucher I, Mione M, Simeone A, Acampora D, Bally Cuif L, Houart C. Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development. 2006;133:1891-900 pubmed
    ..This maintenance is enough to allow cerebellar differentiation. ..
  4. Li H, Kloosterman W, Fekete D. MicroRNA-183 family members regulate sensorineural fates in the inner ear. J Neurosci. 2010;30:3254-63 pubmed publisher
    ..Our findings suggest both distinct and common roles for the three miRNAs in cell-fate determination in the inner ear, and these principles might apply to development of other sensory organs. ..
  5. Mattes B, Weber S, Peres J, Chen Q, Davidson G, Houart C, et al. Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain. Neural Dev. 2012;7:12 pubmed publisher
    ..We propose that Wnt ligands are necessary to maintain the primordial tissue of the organizer during somitogenesis by suppressing Tp53-mediated apoptosis. ..
  6. Albuixech Crespo B, López Blanch L, Burguera D, Maeso I, Sánchez Arrones L, Moreno Bravo J, et al. Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biol. 2017;15:e2001573 pubmed publisher
    ..This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice. ..
  7. Choe S, Lu P, Nakamura M, Lee J, SAGERSTROM C. Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. Dev Cell. 2009;17:561-7 pubmed publisher
    ..We conclude that Meis acts, at least in part, by controlling access of HDAC and CBP to Hox-regulated promoters. ..
  8. Ma W, Zhang J. Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development. 2015;142:763-73 pubmed publisher
    ..Thus, Jag1b uses two distinct mechanisms to form three sensory cristae in zebrafish. ..
  9. Lane B, Lister J. Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development. PLoS ONE. 2012;7:e49357 pubmed publisher
    ..The role of the three Otx transcription factors (Otx1a, Otx1b, and Otx2) and two Mitf transcription factors (Mitfa and Mitfb) in the development of the zebrafish RPE was ..

More Information

Publications11

  1. Vemaraju S, Kantarci H, Padanad M, Riley B. A spatial and temporal gradient of Fgf differentially regulates distinct stages of neural development in the zebrafish inner ear. PLoS Genet. 2012;8:e1003068 pubmed publisher
    ..Thus Fgf signaling renders SAG development self-regulating, ensuring steady production of an appropriate number of neurons as the larva grows...
  2. Su C, Kemp H, Moens C. Cerebellar development in the absence of Gbx function in zebrafish. Dev Biol. 2014;386:181-90 pubmed publisher
    ..Based on our findings we propose a revised model for the role of Gbx in cerebellar development. ..