Gene Symbol: oprl1
Description: opiate receptor-like 1
Alias: oprl, nociceptin receptor, nop, opioid receptor-like protein Zf-orl
Macho Sanchez Simon F, Rodriguez R. Expression of the nociceptin receptor during zebrafish development: influence of morphine and nociceptin. Int J Dev Neurosci. 2009;27:315-20 pubmed publisher
The NOP system is considered to be part of the opioid system, although it exerts antiopioid actions depending on the anatomical region where it is localized...
Dreborg S, Sundstrom G, Larsson T, Larhammar D. Evolution of vertebrate opioid receptors. Proc Natl Acad Sci U S A. 2008;105:15487-92 pubmed publisher
..representing a broader range of vertebrates and found that the four opioid receptor types (delta, kappa, mu, and NOP) are present in most of the species...
Rivas Boyero A, Herrero Turrion M, Gonzalez Nunez V, Sanchez Simon F, Barreto Valer K, Rodriguez R. Pharmacological characterization of a nociceptin receptor from zebrafish (Danio rerio). J Mol Endocrinol. 2011;46:111-23 pubmed publisher
The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory...
Arsequell G, Rosa M, Mayato C, Dorta R, Gonzalez Nunez V, Barreto Valer K, et al
. Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ. Org Biomol Chem. 2011;9:6133-42 pubmed publisher
..the biological activity of the N/OFQ peptide, which is the native ligand of the pain-related and viable drug target NOP receptor, could be modulated by glycosylation and if such effects could be conformationally related, we have ..
Zucchi S, Castiglioni S, Fent K. Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio). Environ Sci Technol. 2013;47:12548-56 pubmed publisher
..The data show molecular effects and the modes of action of P4 at environmental concentrations. Ultimately they may translate to adverse effects on reproduction. ..