opn1mw4

Summary

Gene Symbol: opn1mw4
Description: opsin 1 (cone pigments), medium-wave-sensitive, 4
Alias: RH2-4, grops2, rh2.4, wu:fk64b02, zfgr2, green-sensitive opsin-4, green cone photoreceptor pigment 4, green-sensitive opsin 2, opsin RH2-4, opsin-1, medium-wave-sensitive 4, rhodopsin-like-2.4 cone opsin
Species: zebrafish
Products:     opn1mw4

Top Publications

  1. Vihtelic T, Doro C, Hyde D. Cloning and characterization of six zebrafish photoreceptor opsin cDNAs and immunolocalization of their corresponding proteins. Vis Neurosci. 1999;16:571-85 pubmed
    ..acid sequences and other vertebrate opsins, the cDNAs encode rhodopsin, two different green opsins (zfgr1 and zfgr2), a red, a blue, and an ultraviolet opsin...
  2. Takechi M, Kawamura S. Temporal and spatial changes in the expression pattern of multiple red and green subtype opsin genes during zebrafish development. J Exp Biol. 2005;208:1337-45 pubmed
    ..These results provide the framework for subsequent studies of opsin gene regulation and for probing functional rationale of the developmental changes by using the power of zebrafish genetics. ..
  3. Alvarez Delfin K, Morris A, Snelson C, Gamse J, Gupta T, Marlow F, et al. Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc Natl Acad Sci U S A. 2009;106:2023-8 pubmed publisher
    ..Based upon these data, we propose a previously undescribed function for tbx2b in photoreceptor cell precursors, to promote the UV cone fate by repressing the rod differentiation pathway. ..
  4. Allison W, Barthel L, Skebo K, Takechi M, Kawamura S, Raymond P. Ontogeny of cone photoreceptor mosaics in zebrafish. J Comp Neurol. 2010;518:4182-95 pubmed publisher
    ..These observations provide baseline data for understanding the development of cone mosaics via comparative analysis of larval and adult cone development in a model species. ..
  5. Davies W, Zheng L, Hughes S, Tamai T, Turton M, Halford S, et al. Functional diversity of melanopsins and their global expression in the teleost retina. Cell Mol Life Sci. 2011;68:4115-32 pubmed publisher
  6. Lagman D, Callado Pérez A, Franzén I, Larhammar D, Abalo X. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. PLoS ONE. 2015;10:e0121330 pubmed publisher
    ..In summary, this study describes several functional differences between transducin gene duplicates resulting from the teleost-specific tetraploidisation. ..
  7. Helvik J, Drivenes O, Naess T, Fjose A, Seo H. Molecular cloning and characterization of five opsin genes from the marine flatfish Atlantic halibut (Hippoglossus hippoglossus). Vis Neurosci. 2001;18:767-80 pubmed
    ..This work shows for the first time molecular isolation of a complete set of retinal visual pigment genes from a marine teleost and describes the first cloning of an ultraviolet-sensitive opsin type from a marine teleost. ..
  8. Luo W, Williams J, Smallwood P, Touchman J, Roman L, Nathans J. Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish. J Biol Chem. 2004;279:19286-93 pubmed
    ..These experiments demonstrate the power of transient transgenesis in zebrafish to efficiently define cis-acting regulatory sequences in an intact vertebrate. ..
  9. Chinen A, Matsumoto Y, Kawamura S. Reconstitution of ancestral green visual pigments of zebrafish and molecular mechanism of their spectral differentiation. Mol Biol Evol. 2005;22:1001-10 pubmed
    ..The four zebrafish RH2 pigments cover nearly an entire range of lambda(max) distribution among vertebrate RH2 pigments and provide an excellent model to study spectral tuning mechanisms of RH2 in vertebrates. ..

More Information

Publications16

  1. Tsujimura T, Chinen A, Kawamura S. Identification of a locus control region for quadruplicated green-sensitive opsin genes in zebrafish. Proc Natl Acad Sci U S A. 2007;104:12813-8 pubmed
    ..5-kb region in the PAC clone conferred the highest expression for its proximal gene. The 0.5-kb region was thus designated as RH2-LCR analogous to the locus control region of the L-M opsin genes of primates. ..
  2. Fraser B, Duval M, Wang H, Allison W. Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. PLoS ONE. 2013;8:e55410 pubmed publisher
    ..Our novel animal model provides control of ablation that will assist in identifying mechanisms required to replace cone photoreceptors clinically to restore daytime vision. ..
  3. Meng F, Braasch I, Phillips J, Lin X, Titus T, Zhang C, et al. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol. 2013;30:1527-43 pubmed publisher
    ..These results show that the independent evolution of retinal degeneration in cavefish can occur by different developmental genetic mechanisms. ..
  4. Koyanagi M, Wada S, Kawano Yamashita E, Hara Y, Kuraku S, Kosaka S, et al. Diversification of non-visual photopigment parapinopsin in spectral sensitivity for diverse pineal functions. BMC Biol. 2015;13:73 pubmed publisher
    ..Current findings could also provide an opportunity to understand the "color" preference of non-visual photoreception. ..
  5. Morrow J, Lazic S, Chang B. A novel rhodopsin-like gene expressed in zebrafish retina. Vis Neurosci. 2011;28:325-35 pubmed publisher
    ..The discovery of a new previously uncharacterized opsin gene in zebrafish retina is surprising given its status as a model system for studies of vertebrate vision and visual development. ..
  6. Chinen A, Hamaoka T, Yamada Y, Kawamura S. Gene duplication and spectral diversification of cone visual pigments of zebrafish. Genetics. 2003;163:663-75 pubmed
  7. Kennedy M, Dunn F, Hurley J. Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones. Neuron. 2004;41:915-28 pubmed
    ..Immunocytochemical analyses revealed that neither light nor cytoplasmic Ca2+ influences the localization of transducin in zebrafish cones. ..