opn1lw2

Summary

Gene Symbol: opn1lw2
Description: opsin 1 (cone pigments), long-wave-sensitive, 2
Alias: lws2, zgc:92632, red-sensitive opsin-2, long-wavelength-sensitive-2 cone opsin, opsin LWS-2, opsin-1, long-wave-sensitive 2, red cone photoreceptor pigment 2
Species: zebrafish

Top Publications

  1. Takechi M, Kawamura S. Temporal and spatial changes in the expression pattern of multiple red and green subtype opsin genes during zebrafish development. J Exp Biol. 2005;208:1337-45 pubmed
    ..These results provide the framework for subsequent studies of opsin gene regulation and for probing functional rationale of the developmental changes by using the power of zebrafish genetics. ..
  2. Chinen A, Hamaoka T, Yamada Y, Kawamura S. Gene duplication and spectral diversification of cone visual pigments of zebrafish. Genetics. 2003;163:663-75 pubmed
  3. Kennedy M, Dunn F, Hurley J. Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones. Neuron. 2004;41:915-28 pubmed
    ..Immunocytochemical analyses revealed that neither light nor cytoplasmic Ca2+ influences the localization of transducin in zebrafish cones. ..
  4. Zhang L, Zhang X, Zhang G, Pang C, Leung Y, Zhang M, et al. Expression profiling of the retina of pde6c, a zebrafish model of retinal degeneration. Sci Data. 2017;4:170182 pubmed publisher
    ..This dataset will facilitate the characterization of the molecular defects in the pde6c retina at the initial stage of retinal degeneration. ..
  5. Weber A, Hochmann S, Cimalla P, Gärtner M, Kuscha V, Hans S, et al. Characterization of light lesion paradigms and optical coherence tomography as tools to study adult retina regeneration in zebrafish. PLoS ONE. 2013;8:e80483 pubmed publisher
    ..Collectively, the light lesion and imaging assays described here represent powerful tools for studying degeneration and regeneration processes in the adult zebrafish retina. ..
  6. Morrow J, Lazic S, Chang B. A novel rhodopsin-like gene expressed in zebrafish retina. Vis Neurosci. 2011;28:325-35 pubmed publisher
    ..The discovery of a new previously uncharacterized opsin gene in zebrafish retina is surprising given its status as a model system for studies of vertebrate vision and visual development. ..
  7. Li W, Zhou L, Li Z, Wang Y, Shi J, Yang Y, et al. Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. Int J Biol Sci. 2015;11:688-700 pubmed publisher
    ..Furthermore, knockdown of lbh-like increases the activity of Notch pathway and perturbs the balance among proliferation, differentiation and survival of photoreceptor precursors. ..
  8. Houbrechts A, Vergauwen L, Bagci E, Van Houcke J, Heijlen M, Kulemeka B, et al. Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Mol Cell Endocrinol. 2016;424:81-93 pubmed publisher
    ..These data demonstrate the importance of TH-activating and -inactivating Ds for correct zebrafish eye development, and point to D3b as a central player. ..
  9. Huang H, Dai E, Liu J, Tu C, Yang T, Tsai H. The embryonic expression patterns and the knockdown phenotypes of zebrafish ADP-ribosylation factor-like 6 interacting protein gene. Dev Dyn. 2009;238:232-40 pubmed publisher
    ..We further confirmed that opsins of arl6ip-morphants were not transcribed. Based on this evidence, Arl6ip may play important roles in zebrafish ocular, heart, and fin-bud development. ..

More Information

Publications18

  1. Allison W, Barthel L, Skebo K, Takechi M, Kawamura S, Raymond P. Ontogeny of cone photoreceptor mosaics in zebrafish. J Comp Neurol. 2010;518:4182-95 pubmed publisher
    ..These observations provide baseline data for understanding the development of cone mosaics via comparative analysis of larval and adult cone development in a model species. ..
  2. Davies W, Zheng L, Hughes S, Tamai T, Turton M, Halford S, et al. Functional diversity of melanopsins and their global expression in the teleost retina. Cell Mol Life Sci. 2011;68:4115-32 pubmed publisher
  3. Alvarez Delfin K, Morris A, Snelson C, Gamse J, Gupta T, Marlow F, et al. Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc Natl Acad Sci U S A. 2009;106:2023-8 pubmed publisher
    ..Based upon these data, we propose a previously undescribed function for tbx2b in photoreceptor cell precursors, to promote the UV cone fate by repressing the rod differentiation pathway. ..
  4. Mitchell D, Stevens C, Frey R, Hunter S, Ashino R, Kawamura S, et al. Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLoS Genet. 2015;11:e1005483 pubmed publisher
    ..Embryos treated with RA 48 hpf to 100 hpf or beyond showed significant reductions in LWS2-expressing cones in favor of LWS1-expressing cones...
  5. Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
    ..In conclusion, we show that both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms. ..
  6. Priyadarshini M, Tuimala J, Chen Y, Panula P. A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling. Neurobiol Dis. 2013;54:127-38 pubmed publisher
    ..Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway. ..
  7. Glaviano A, Smith A, Blanco A, McLoughlin S, Cederlund M, Heffernan T, et al. A method for isolation of cone photoreceptors from adult zebrafish retinae. BMC Neurosci. 2016;17:71 pubmed
    ..In addition, this advancement facilitates the identification of novel candidate genes for inherited human blindness. ..
  8. Linder B, Dill H, Hirmer A, Brocher J, Lee G, Mathavan S, et al. Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa. Hum Mol Genet. 2011;20:368-77 pubmed publisher
    ..Hence, various routes affecting the tri-snRNP can elicit tissue-specific gene expression defects and lead to the RP phenotype. ..
  9. Tsujimura T, Hosoya T, Kawamura S. A single enhancer regulating the differential expression of duplicated red-sensitive opsin genes in zebrafish. PLoS Genet. 2010;6:e1001245 pubmed publisher
    ..Sharing a regulatory region between duplicated genes could be a general way to facilitate the expression differentiation in duplicated visual opsins. ..