ompb

Summary

Gene Symbol: ompb
Description: olfactory marker protein b
Alias: omp, zgc:101697, olfactory marker protein b, OMP1
Species: zebrafish

Top Publications

  1. Sato Y, Miyasaka N, Yoshihara Y. Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish. J Neurosci. 2005;25:4889-97 pubmed
    ..OSNs express OR-type odorant receptors, cyclic nucleotide-gated channel A2 subunit, and olfactory marker protein (OMP), whereas the microvillous OSNs express V2R-type receptors and transient receptor potential channel C2 (TRPC2)...
  2. Koide T, Miyasaka N, Morimoto K, Asakawa K, Urasaki A, Kawakami K, et al. Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish. Proc Natl Acad Sci U S A. 2009;106:9884-9 pubmed publisher
    ..Thus, the integrated approach combining genetic, neuroanatomical, and behavioral methods enables us to elucidate the neural circuit mechanism underlying various olfactory behaviors in adult zebrafish. ..
  3. Oka Y, Saraiva L, Korsching S. Crypt neurons express a single V1R-related ora gene. Chem Senses. 2012;37:219-27 pubmed publisher
    ..Such an expression pattern is familiar in the visual system, with rhodopsin as the sole light receptor of rod photoreceptor cells, but unexpected in the sense of smell. ..
  4. Celik A, Fuss S, Korsching S. Selective targeting of zebrafish olfactory receptor neurons by the endogenous OMP promoter. Eur J Neurosci. 2002;15:798-806 pubmed
    ..g. the olfactory receptor neurons, have been established in this species. Olfactory marker protein (OMP) is a reliable marker for olfactory receptor neurons in several other vertebrates...
  5. Ferreira T, Wilson S, Choi Y, Risso D, Dudoit S, Speed T, et al. Silencing of odorant receptor genes by G protein ?? signaling ensures the expression of one odorant receptor per olfactory sensory neuron. Neuron. 2014;81:847-59 pubmed publisher
    ..These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron. ..
  6. Pogoda H, von der Hardt S, Herzog W, Kramer C, Schwarz H, Hammerschmidt M. The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis. Development. 2006;133:1079-89 pubmed
    ..Together, this suggests that Ascl1a might act downstream of diencephalic Fgf3 signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis...
  7. Lakhina V, Marcaccio C, Shao X, Lush M, Jain R, Fujimoto E, et al. Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb. J Neurosci. 2012;32:4440-56 pubmed publisher
    ..These findings implicate Netrins as the only known attractants for olfactory sensory neurons, first drawing OR111-7-expressing axons into the bulb and then into the ventromedially positioned central zone protoglomerulus. ..
  8. Blumhagen F, Zhu P, Shum J, Schärer Y, Yaksi E, Deisseroth K, et al. Neuronal filtering of multiplexed odour representations. Nature. 2011;479:493-8 pubmed publisher
    ..These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes. ..
  9. Henshall T, Tucker B, Lumsden A, Nornes S, Lardelli M, Richards R. Selective neuronal requirement for huntingtin in the developing zebrafish. Hum Mol Genet. 2009;18:4830-42 pubmed publisher
    ..These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types. ..

More Information

Publications24

  1. Madelaine R, Garric L, Blader P. Partially redundant proneural function reveals the importance of timing during zebrafish olfactory neurogenesis. Development. 2011;138:4753-62 pubmed publisher
    ..We conclude that the duration of proneural expression in EON progenitors is crucial for correct development of the zebrafish olfactory system. ..
  2. Onuma T, Ding Y, Abraham E, Zohar Y, Ando H, Duan C. Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish. J Neurosci. 2011;31:11814-24 pubmed publisher
    ..These results suggest that the IGF-IGF1R-PI3K pathway regulates the precise temporal and spatial organization of GnRH neurons in zebrafish and provides new insights into the regulation of GnRH neuron development. ..
  3. Bayramli X, Kocagoz Y, Sakizli U, Fuss S. Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons. Sci Rep. 2017;7:5572 pubmed publisher
    ..We formulated a simple mathematical model based on exact parameters derived from our analysis of OSN neurogenesis, which accurately generates OR-like distributions without the need to invoke molecular signals to pattern the OE. ..
  4. Tan S, Kee M, Mathuru A, Burkholder W, Jesuthasan S. A microfluidic device to sort cells based on dynamic response to a stimulus. PLoS ONE. 2013;8:e78261 pubmed publisher
    ..Responsive cells all expressed TRPC2 but not OMP, consistent with known properties of amino-acid sensitive olfactory neurons...
  5. Wang L, Gallagher E. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicol Appl Pharmacol. 2013;266:177-86 pubmed publisher
    ..Moreover, the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function. ..
  6. Chen X, Yoshida T, Sagara H, Mikami Y, Mishina M. Protein tyrosine phosphatase ? regulates the synapse number of zebrafish olfactory sensory neurons. J Neurochem. 2011;119:532-43 pubmed publisher
    ..The density of docked vesicles at the active zone was also increased significantly. Our results suggest that presynaptic PTP? controls the number of OSN-mitral cell synapses by suppressing their excessive increase. ..
  7. Yoshida T, Uchida S, Mishina M. Regulation of synaptic vesicle accumulation and axon terminal remodeling during synapse formation by distinct Ca signaling. J Neurochem. 2009;111:160-70 pubmed publisher
    ..Our results suggest that IP(3)-mediated Ca(2+)/calmodulin signaling stimulates synaptic vesicle accumulation and subsequent neuronal activity-dependent Ca(2+)/calmodulin signaling induces the morphological remodeling of axon terminals. ..
  8. Tilton F, Tilton S, Bammler T, Beyer R, Farin F, Stapleton P, et al. Transcriptional biomarkers and mechanisms of copper-induced olfactory injury in zebrafish. Environ Sci Technol. 2008;42:9404-11 pubmed
    ..Further, these data provide a mechanistic explanation in support of earlier studies of functional olfactory impairment in fish following copper exposure. ..
  9. Pfister P, Randall J, Montoya Burgos J, Rodriguez I. Divergent evolution among teleost V1r receptor genes. PLoS ONE. 2007;2:e379 pubmed publisher
    ..Our results suggest a conserved agonist specificity of the V1R2 receptor between euteleost species, its loss in the tetraodontidae lineage, and the acquisition of different chemosensory characteristics for the V1R1 receptor...
  10. Yoshida T, Mishina M. Neuron-specific gene manipulations to transparent zebrafish embryos. Methods Cell Sci. 2003;25:15-23 pubmed
    ..expressing zebrafish lines, we first established that EGFP under control of either the olfactory marker protein (OMP) gene promoter or the nicotinic acetylcholine receptor beta3 (nAChRbeta3) gene promoter, directed strong EGFP ..
  11. Rentzsch F, Kramer C, Hammerschmidt M. Specific and conserved roles of TAp73 during zebrafish development. Gene. 2003;323:19-30 pubmed
    ..Together, our data point to both conserved and class-specific roles of p73 during vertebrate development. ..
  12. Duggan C, DeMaria S, Baudhuin A, Stafford D, Ngai J. Foxg1 is required for development of the vertebrate olfactory system. J Neurosci. 2008;28:5229-39 pubmed publisher
    ..Therefore, we identified an evolutionarily conserved requirement for Foxg1 in the development of the vertebrate olfactory system. ..
  13. DeMaria S, Berke A, Van Name E, Heravian A, Ferreira T, Ngai J. Role of a ubiquitously expressed receptor in the vertebrate olfactory system. J Neurosci. 2013;33:15235-47 pubmed publisher
  14. Garaffo G, Conte D, Provero P, Tomaiuolo D, Luo Z, Pinciroli P, et al. The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system. Mol Cell Neurosci. 2015;68:103-19 pubmed publisher
  15. Suzuki H, Nikaido M, Hagino Yamagishi K, Okada N. Distinct functions of two olfactory marker protein genes derived from teleost-specific whole genome duplication. BMC Evol Biol. 2015;15:245 pubmed publisher
    ..Our genome database search identified two OMPs (OMP1 and OMP2) in teleosts, whereas only one was present in other vertebrates...