Gene Symbol: OMP 1
Description: otolith matrix protein
Alias: im:6904989, omp, omp-1, wu:fc44d11, zomp1, otolith matrix protein 1
Murayama E, Herbomel P, Kawakami A, Takeda H, Nagasawa H. Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mech Dev. 2005;122:791-803 pubmed
..Previously, we identified two major otolith matrix proteins, OMP-1 (otolith matrix protein-1) and Otolin-1, from salmonid species...
Schibler A, Malicki J. A screen for genetic defects of the zebrafish ear. Mech Dev. 2007;124:592-604 pubmed
..As it proved to be the case in past screening efforts of this type, these mutant lines represent an asset in the studies of molecular mechanisms that regulate vertebrate ear development. ..
Petko J, Millimaki B, Canfield V, Riley B, Levenson R. Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish. Dev Neurobiol. 2008;68:209-22 pubmed
..Otoconin-90 (Oc90) is the major matrix protein of mammalian and avian otoconia, while otolith matrix protein (OMP) is the most abundant matrix protein found in the otoliths of teleost fish...
Stooke Vaughan G, Huang P, Hammond K, Schier A, Whitfield T. The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development. 2012;139:1777-87 pubmed publisher
..Our data support a model in which hair cells produce an otolith precursor-binding factor, normally localised to tether cell kinocilia. We also show that embryonic movement plays a minor role in the formation of normal otoliths. ..
Hughes I, Blasiole B, Huss D, Warchol M, Rath N, Hurle B, et al
. Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Dev Biol. 2004;276:391-402 pubmed
..These studies demonstrate that Otop1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith...
Han Y, Mu Y, Li X, Xu P, Tong J, Liu Z, et al
. Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Hum Mol Genet. 2011;20:3213-26 pubmed publisher
..Thus, this work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss...
Yang C, Cheng C, Chen G, Liao W, Chen Y, Huang K, et al
. Zona pellucida domain-containing protein ?-tectorin is crucial for zebrafish proper inner ear development. PLoS ONE. 2011;6:e23078 pubmed publisher
..Tectorin is specifically expressed in the mammalian and avian inner ear...
Khuansuwan S, Gamse J. Identification of differentially expressed genes during development of the zebrafish pineal complex using RNA sequencing. Dev Biol. 2014;395:144-53 pubmed publisher
..This protocol brings modern transcriptome analysis to the study of small cell populations in zebrafish. ..