Gene Symbol: Oct 6
Description: POU class 3 homeobox 1
Alias: pou50, wu:fc09d06, zp-50, zp50, zp50pou, POU domain, class 3, transcription factor 1, Oct-6, POU domain gene 50, POU domain protein 50, POU domain protein ZP-50
Hauptmann G, Söll I, Gerster T. The early embryonic zebrafish forebrain is subdivided into molecularly distinct transverse and longitudinal domains. Brain Res Bull. 2002;57:371-5 pubmed
..Furthermore, we identified a series of eight transverse diencephalic domains which may indicate a prosomeric organization of the rostral zebrafish brain. ..
Lister J, Cooper C, Nguyen K, Modrell M, Grant K, Raible D. Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. Dev Biol. 2006;290:92-104 pubmed
Monk K, Naylor S, Glenn T, Mercurio S, Perlin J, Dominguez C, et al
. A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science. 2009;325:1402-5 pubmed publisher
..We propose that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination. ..
Levavasseur F, Mandemakers W, Visser P, Broos L, Grosveld F, Zivkovic D, et al
. Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse. Mech Dev. 1998;74:89-98 pubmed
Hauptmann G, Gerster T. Regulatory gene expression patterns reveal transverse and longitudinal subdivisions of the embryonic zebrafish forebrain. Mech Dev. 2000;91:105-18 pubmed
..Our data suggest a strong conservation of early forebrain organization between lower and higher vertebrates. ..
Hauptmann G, Gerster T. Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches. Dev Dyn. 2000;218:345-58 pubmed
..We propose that coordinate expression of particular combinations of class III POU genes contribute to pattern formation or cell fate determination in the developing CNS and other structures. ..
Moore A, Mark T, Hogan A, Topczewski J, LeClair E. Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration. J Comp Neurol. 2012;520:4184-203 pubmed publisher
..The accessible ZMB provides a novel context for studying axon regeneration, Schwann cell migration, and remyelination in a model vertebrate. ..
Langworthy M, Appel B. Schwann cell myelination requires Dynein function. Neural Dev. 2012;7:37 pubmed publisher
..Our data now provide evidence that Dync1h1 is also required for efficient myelination of peripheral axons by Schwann cells, perhaps by facilitating signal transduction necessary for myelination. ..
Raphael A, Lyons D, Talbot W. ErbB signaling has a role in radial sorting independent of Schwann cell number. Glia. 2011;59:1047-55 pubmed publisher
..These results provide in vivo evidence that ErbB signaling plays a direct role in process extension during radial sorting, in addition to its role in regulating Schwann cell proliferation. ..