Gene Symbol: nsfa
Description: N-ethylmaleimide-sensitive factor a
Alias: nsf, si:bz18k17.1, wu:fj33g11, vesicle-fusing ATPase
Species: zebrafish
Products:     nsfa

Top Publications

  1. Woods I, Lyons D, Voas M, Pogoda H, Talbot W. nsf is essential for organization of myelinated axons in zebrafish. Curr Biol. 2006;16:636-48 pubmed
    ..Starting with a forward genetic screen in zebrafish, we have identified an essential requirement for nsf (N-ethylmaleimide sensitive factor) in the organization of myelinated axons...
  2. Kurrasch D, Nevin L, Wong J, Baier H, Ingraham H. Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Dev. 2009;4:22 pubmed publisher
    ..To our surprise, the ATPase N-ethylmaleimide sensitive factor (nsf) was identified as an essential gene for maintenance of neuroendocrine transcriptional programs during the embryo-..
  3. McDermott B, Baucom J, Hudspeth A. Analysis and functional evaluation of the hair-cell transcriptome. Proc Natl Acad Sci U S A. 2007;104:11820-5 pubmed
    ..Moreover, a search for candidate genes that underlie heritable deafness identified a human ortholog of a zebrafish hair-cell gene whose map location is bracketed by the markers of a deafness locus. ..
  4. Nishiwaki Y, Yoshizawa A, Kojima Y, Oguri E, Nakamura S, Suzuki S, et al. The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects. Dev Cell. 2013;25:374-87 pubmed publisher
    ..These data suggest that the syntaxin-18 cis-SNARE complex functions as an alarm factor that monitors vesicular fusion competence and that BNip1 transforms vesicular fusion defects into photoreceptor apoptosis. ..
  5. Balciuniene J, Nagelberg D, Walsh K, Camerota D, Georlette D, Biemar F, et al. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. BMC Genomics. 2013;14:619 pubmed publisher
    ..Three of our gene trap alleles display homozygous lethal phenotypes ranging from embryonic to late larval: nsf(?tpl6), atp1a3a(tpl10) and flr(tpl19)...
  6. Hanovice N, Daly C, Gross J. N-Ethylmaleimide-Sensitive Factor b (nsfb) Is Required for Normal Pigmentation of the Zebrafish Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2015;56:7535-44 pubmed publisher
    ..au18 and au13 contain mutations in nsfb, which encodes a protein that is required for the maturation of melanosomes in zebrafish RPE. ..
  7. Moravec C, Samuel J, Weng W, Wood I, Sirotkin H. Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. J Neurosci. 2016;36:9407-19 pubmed publisher
  8. Prats E, Gómez Canela C, Ben Lulu S, Ziv T, Padrós F, Tornero D, et al. Modelling acrylamide acute neurotoxicity in zebrafish larvae. Sci Rep. 2017;7:13952 pubmed publisher
    ..These data support the suitability of the developed zebrafish model for screening of molecules with therapeutic value against this toxic neuropathy. ..
  9. Pogoda H, Sternheim N, Lyons D, Diamond B, Hawkins T, Woods I, et al. A genetic screen identifies genes essential for development of myelinated axons in zebrafish. Dev Biol. 2006;298:118-31 pubmed
    ..The analysis of these mutations will advance our understanding of myelination, and the mutants will serve as models of human diseases of myelin. ..

More Information


  1. Patten S, Ali D. PKCgamma-induced trafficking of AMPA receptors in embryonic zebrafish depends on NSF and PICK1. Proc Natl Acad Sci U S A. 2009;106:6796-801 pubmed publisher
    ..of AMPAR-mediated miniature excitatory postsynaptic currents (AMPA-mEPSCs) via a N-ethylmaleimide-sensitive fusion (NSF) and protein interacting with C-kinase-1 (PICK1)-dependent process...
  2. Singh S, Saxena S, Meena Lakshmi M, Saxena P, Idris M. Proteome profile of zebrafish Danio rerio olfactory bulb based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 2011;8:183-9 pubmed publisher
    ..This study provides the D. rerio olfactory bulb two-dimensional gel electrophoresis proteome map and the details of 221 olfactory bulb-specific proteins. ..
  3. Fontenas L, De Santis F, Di Donato V, Degerny C, Chambraud B, Del Bene F, et al. Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. PLoS Genet. 2016;12:e1006459 pubmed publisher
    ..Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis...