Gene Symbol: nrp2b
Description: neuropilin 2b
Alias: id:ibd2759, npn-2B, sb:cb513, neuropilin 2b
Species: zebrafish

Top Publications

  1. Yu H, Houart C, Moens C. Cloning and embryonic expression of zebrafish neuropilin genes. Gene Expr Patterns. 2004;4:371-8 pubmed
    ..of neuropilins in zebrafish embryogenesis, we have cloned three zebrafish neuropilin homologues, nrp1b, nrp2a and nrp2b. Based on synteny, zebrafish nrp1b and the previously cloned nrp1a are orthologous to human nrp1, and zebrafish ..
  2. Taku A, Marcaccio C, Ye W, Krause G, Raper J. Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target. Development. 2016;143:123-32 pubmed publisher
    ..Further analysis indicates that Sema3D signaling is mediated through Nrp1a, while Nrp2b also promotes CZ targeting but in a Sema3D-independent manner...
  3. Kuan Y, Yu H, Moens C, Halpern M. Neuropilin asymmetry mediates a left-right difference in habenular connectivity. Development. 2007;134:857-65 pubmed
    ..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side. ..
  4. Bovenkamp D, Goishi K, Bahary N, Davidson A, Zhou Y, Becker T, et al. Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish. Gene Expr Patterns. 2004;4:361-70 pubmed
    ..USA 99 (2002) 10470]. Subsequently, we have isolated three other full-length neuropilin genes (nrp1b, nrp2a, and nrp2b) and find that they map to independent zebrafish linkage groups...
  5. Martyn U, Schulte Merker S. Zebrafish neuropilins are differentially expressed and interact with vascular endothelial growth factor during embryonic vascular development. Dev Dyn. 2004;231:33-42 pubmed
    ..We identified four zebrafish nrp genes, nrp1a, nrp1b, nrp2a, and nrp2b, and characterized their function in vascular development...
  6. Xia Z, Tong X, Liang F, Zhang Y, Kuok C, Zhang Y, et al. Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. Dev Biol. 2013;381:83-96 pubmed publisher
    ..The expression of several neural crest marker genes, including crestin, dlx2a and nrp2b, was specifically reduced in the cranial regions of the eif3ba mutant...
  7. Terriente J, Gerety S, Watanabe Asaka T, Gonzalez Quevedo R, Wilkinson D. Signalling from hindbrain boundaries regulates neuronal clustering that patterns neurogenesis. Development. 2012;139:2978-87 pubmed publisher
    ..Sema3 signalling from boundaries thus links hindbrain segmentation to the positioning of fgf20a-expressing neurons that regulates neurogenesis. ..
  8. Sumanas S, Kim H, Hermanson S, Ekker S. Lateral line, nervous system, and maternal expression of Frizzled 7a during zebrafish embryogenesis. Mech Dev. 2002;115:107-11 pubmed
    ..00cR, LOD score 14.1). To prove that fz7 and fz7a are indeed different genes we mapped fz7 as well using the same LN54 panel. Fz7 mapped to linkage group 9 with a LOD of 12.5, 27.31 cR from wnt 10a in between markers IBD2759 and fb50e04. ..
  9. Liu J, Sun Y, Wang Y, Wang N, Pei D, Wang Y, et al. Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology. 2008;70:1525-35 pubmed publisher
    ..One gene (ZR6), dramatically down-regulated in RZ embryos, was chosen for loss-of-function study; the knockdown of ZR6 gave rise to the phenotype resembling that of RZ embryos. ..

More Information


  1. Tanaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, et al. Novel mutations affecting axon guidance in zebrafish and a role for plexin signalling in the guidance of trigeminal and facial nerve axons. Development. 2007;134:3259-69 pubmed
  2. Love C, Prince V. Rest represses maturation within migrating facial branchiomotor neurons. Dev Biol. 2015;401:220-35 pubmed publisher
    ..We conclude that Rest functions in FBMN nuclei to inhibit maturation until the neurons complete their migration. ..
  3. Hillman R, Feng B, Ni J, Woo W, Milenkovic L, Hayden Gephart M, et al. Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 2011;25:2333-46 pubmed publisher
    ..These findings enhance our knowledge of Hh pathway regulation and provide evidence for a conserved nexus between Nrps and this important developmental signaling system. ..
  4. Akitake C, Macurak M, Halpern M, Goll M. Transgenerational analysis of transcriptional silencing in zebrafish. Dev Biol. 2011;352:191-201 pubmed publisher
  5. Yu H, Moens C. Semaphorin signaling guides cranial neural crest cell migration in zebrafish. Dev Biol. 2005;280:373-85 pubmed
    ..We find that genes of the sema3F and sema3G class are expressed in the cranial NC-free zones, while nrp2a and nrp2b are expressed in the migrating NCCs...
  6. Wolman M, Liu Y, Tawarayama H, Shoji W, Halloran M. Repulsion and attraction of axons by semaphorin3D are mediated by different neuropilins in vivo. J Neurosci. 2004;24:8428-35 pubmed
    ..Together, these data support the hypothesis that Sema3D may act as a repellent through receptors containing Npn-1A and as an attractant via receptors containing Npn-1A and Npn-2B. ..
  7. Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, et al. Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell. 2015;32:181-90 pubmed publisher
    ..Our work reveals a β1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by CCM proteins. This regulation prevents angiogenic overgrowth and ensures the quiescence of endothelial cells. ..
  8. Liu Y, Berndt J, Su F, Tawarayama H, Shoji W, Kuwada J, et al. Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. J Neurosci. 2004;24:310-8 pubmed
    ..These results suggest that Sema3D in the ventral tectum normally acts to inhibit ventral RGCs from extending into ventral tectum, ensuring their correct innervation of dorsal tectum. ..