Gene Symbol: nrl
Description: neural retina leucine zipper
Alias: zgc:136315, neural retina-specific leucine zipper protein, leucine zipper transcription factor
Nelson S, Frey R, Wardwell S, Stenkamp D. The developmental sequence of gene expression within the rod photoreceptor lineage in embryonic zebrafish. Dev Dyn. 2008;237:2903-17 pubmed publisher
..Postmitotic, maturing rods also expressed nrl, rod opsin, and rod transducin/gnat1...
Hao H, Veleri S, Sun B, Kim D, Keeley P, Kim J, et al
. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Hum Mol Genet. 2014;23:4260-71 pubmed publisher
The Maf-family leucine zipper transcription factor NRL is essential for rod photoreceptor development and functional maintenance in the mammalian retina...
Coolen M, Sii Felice K, Bronchain O, Mazabraud A, Bourrat F, R taux S, et al
. Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans. Dev Genes Evol. 2005;215:327-39 pubmed publisher
..analysis shows that, in osteichthyans, the large Maf family contains four orthology classes, MafA, MafB, c-Maf and Nrl, which have emerged in vertebrates prior to the split between actinopterygians and sarcopterygians...
Zhang Y, Yang Y, Trujillo C, Zhong W, Leung Y. The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination. PLoS ONE. 2012;7:e36145 pubmed publisher
..Since the expression of known TFs that can specify specific retinal cell type was also altered in Irx7-deficient retinas, thus the irx7 gene network is possibly a novel regulatory circuit for retinal development and lamination. ..
Meng F, Braasch I, Phillips J, Lin X, Titus T, Zhang C, et al
. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol. 2013;30:1527-43 pubmed publisher
..These results show that the independent evolution of retinal degeneration in cavefish can occur by different developmental genetic mechanisms. ..
Viringipurampeer I, Shan X, Gregory Evans K, Zhang J, Mohammadi Z, Gregory Evans C. Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell Death Differ. 2014;21:665-75 pubmed publisher
..As bystander cell death is an important feature of many retinal diseases, combinatorial approaches targeting different cell death pathways may evolve as an important general principle in treatment. ..
Gao M, Zhang S, Liu C, Qin Y, Archacki S, Jin L, et al
. Whole exome sequencing identifies a novel NRL mutation in a Chinese family with autosomal dominant retinitis pigmentosa. Mol Vis. 2016;22:234-42 pubmed
..The novel c.146 C>T mutation in NRL was found to be the only mutation that co-segregated with the disease in this pedigree...
Kim J, Yang H, Oel A, Brooks M, Jia L, Plachetzki D, et al
. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Dev Cell. 2016;37:520-32 pubmed publisher
..supports the hypothesis that, in mammals, the S-cone lineage was recruited via the Maf-family transcription factor NRL to augment rod photoreceptors...
Asaoka Y, Hata S, Namae M, Furutani Seiki M, Nishina H. The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE. 2014;9:e97365 pubmed publisher
..Our results suggest that Yap suppresses the differentiation of photoreceptor cells from retinal progenitor cells by repressing Rx1-mediated transactivation of photoreceptor cell genes during zebrafish retinogenesis. ..