Gene Symbol: nr1d2b
Description: nuclear receptor subfamily 1, group D, member 2b
Alias: reverbb, reverbb2, zgc:92019, nuclear receptor subfamily 1 group D member 2, NR1D2-B, Rev-Erb beta 2, rev erb beta 2, rev-erb-beta
Robinson Rechavi M, Marchand O, Escriva H, Bardet P, Zelus D, Hughes S, et al
. Euteleost fish genomes are characterized by expansion of gene families. Genome Res. 2001;11:781-8 pubmed publisher
..Redundancy appears to be the rule in fish developmental genetics. Finally, our results imply that the outcome of genome projects cannot be extrapolated easily between fish species...
Laranjeiro R, Tamai T, Peyric E, Krusche P, Ott S, Whitmore D. Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing. Proc Natl Acad Sci U S A. 2013;110:6835-40 pubmed publisher
..Such differences provide a unique mechanism whereby S phase is set to different times of day in a tissue-specific manner, depending on the balance of these two inhibitors...
Zhao Y, Zhang K, Fent K. Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones. Environ Pollut. 2018;232:422-429 pubmed publisher
..Our results suggest that steroid hormones can modulate the circadian molecular network in zebrafish and provide novel insights into their mode of actions and potential environmental risks. ..
Amaral I, Johnston I. Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2012;302:R193-206 pubmed publisher
..The role of circadian clocks in regulating muscle maintenance and growth are discussed. ..
Krasowski M, Yasuda K, Hagey L, Schuetz E. Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept. 2005;3:2 pubmed
..NR genes generally show strong sequence conservation and little evidence for positive selection. The main exceptions are PXR and CAR, genes that may have adapted to cross-species differences in toxic compound exposure. ..
Kakizawa T, Nishio S, Triqueneaux G, Bertrand S, Rambaud J, Laudet V. Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha. J Mol Endocrinol. 2007;38:555-68 pubmed
..Together, these data suggest that ZfP1 is orthologous to the mammalian P1 promoter, whereas zebrafish ZfP2 has no mammalian ortholog and does not function like ZfP1 to control Rev-erbalpha expression. ..
Gavriouchkina D, Fischer S, Ivacevic T, Stolte J, Benes V, Dekens M. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS ONE. 2010;5:e12542 pubmed publisher
..These data leads us to propose their involvement in light-induced UV tolerance in the zebrafish embryo. ..
Zucchi S, Castiglioni S, Fent K. Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio). Environ Sci Technol. 2013;47:12548-56 pubmed publisher
..5 and 306 ng/L, respectively. Genes related to circadian rhythm (nr1d2b, per1b), cell cycle and reproduction (cdc20, ccnb1) were down-regulated...
Zucchi S, Mirbahai L, Castiglioni S, Fent K. Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:3523-31 pubmed publisher
..Effects of DRS and P4 were additive for most of the investigated parameters and occurred at environmentally relevant concentrations. They may translate to adverse reproductive effects in fish. ..