Gene Symbol: npy
Description: neuropeptide Y
Alias: si:dkey-22m8.5, pro-neuropeptide Y
Species: zebrafish
Products:     npy

Top Publications

  1. Fredriksson R, Sjödin P, Larson E, Conlon J, Larhammar D. Cloning and characterization of a zebrafish Y2 receptor. Regul Pept. 2006;133:32-40 pubmed
    The NPY receptors belong to the superfamily of G-protein coupled receptors and in mammals this family has five members, named Y1, Y2, Y4, Y5, and Y6. In bony fish, four receptors have been identified, named Ya, Yb, Yc and Y7...
  2. Sundstrom G, Larsson T, Brenner S, Venkatesh B, Larhammar D. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Gen Comp Endocrinol. 2008;155:705-16 pubmed
    Despite sequence information from many vertebrates the evolution of the neuropeptide Y (NPY) family of peptides has been difficult to resolve, particularly among ray-finned fishes...
  3. Fällmar H, Sundstrom G, Lundell I, Mohell N, Larhammar D. Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties. Comp Biochem Physiol B Biochem Mol Biol. 2011;160:166-73 pubmed publisher
    ..The ancestral jawed vertebrate had 7 NPY receptors but the number varies between 4 and 7 in extant vertebrates...
  4. Piccinetti C, Migliarini B, Olivotto I, Coletti G, Amici A, Carnevali O. Appetite regulation: the central role of melatonin in Danio rerio. Horm Behav. 2010;58:780-5 pubmed publisher
    ..For the first time, in fact, melatonin control of food intake by the modulation of leptin, MC4R, ghrelin, NPY and CB1 gene expression was evaluated...
  5. Larsson T, Larson E, Fredriksson R, Conlon J, Larhammar D. Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. Peptides. 2006;27:1320-7 pubmed
    We report the cloning and pharmacological characterization of two neuropeptide Y (NPY) receptor subtypes, Y2 and Y7, in rainbow trout (Oncorhynchus mykiss)...
  6. Yokobori E, Azuma M, Nishiguchi R, Kang K, Kamijo M, Uchiyama M, et al. Neuropeptide Y stimulates food intake in the Zebrafish, Danio rerio. J Neuroendocrinol. 2012;24:766-73 pubmed publisher
    Neuropeptide Y (NPY) is a potent orexigenic neuropeptide implicated in feeding regulation in mammals. However, except for the case of the goldfish, the involvement of NPY in the feeding behaviour of teleost fish has not well been studied...
  7. Sundstrom G, Larsson T, Brenner S, Venkatesh B, Larhammar D. Ray-fin fish tetraploidization gave rise to pufferfish duplicates of NPY and PYY, but zebrafish NPY duplicate was lost. Ann N Y Acad Sci. 2005;1040:476-8 pubmed
    We have used sequence information and gene location to identify NPY family genes in the pufferfish, Takifugu rubripes (fugu), and zebrafish. Fugu has two copies of NPY, presumably resulting from the ray-fin fish tetraploidization...
  8. Bottaro M, Ferrando S, Ravera S, Vacchi M, Gallus L, Gambardella C, et al. First detection of neuropeptide Y (NPY)-like immunoreactivity in the lateral line: presence and distribution in the neuromasts of the Antarctic notothenioid fish Trematomus bernacchii. Neurosci Lett. 2009;458:37-42 pubmed publisher
    ..Neuropeptide Y (NPY) has a number of functions in vertebrate physiology and also plays important roles in different sensory systems...
  9. Lopes M, Sapio M, Leal R, Fricker L. Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. PLoS ONE. 2016;11:e0152905 pubmed publisher
    ..Knockdown of cpa6 mRNA also reduced the levels of mRNAs encoding neuropeptide precursors (bdnf, npy, chga, pcsk1nl, tac1, nts, edn1), a neuropeptide processing enzyme (cpe), transcription factor (c-fos), and ..

More Information


  1. Chen H, Huang H, Chen X, Deng S, Zhu C, Huang H, et al. Structural and functional characterization of neuromedin S in the teleost fish, zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2016;191:76-83 pubmed publisher
    ..of zebrafish NMSRP by intraperitoneal injection significantly promoted the expression of neuropeptide Y (NPY) and orexin, suggesting an orexigenic role for NMSRP in zebrafish...
  2. Wong R, Oxendine S, Godwin J. Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment. BMC Genomics. 2013;14:348 pubmed publisher
    ..This study provides data that could help identify common molecular mechanisms of fluoxetine action across animal taxa. ..
  3. Zheng B, Li S, Liu Y, Li Y, Chen H, Tang H, et al. Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study. Sci Rep. 2017;7:14643 pubmed publisher
    ..However, the hyperphagia did not lead to a higher growth rate or body fat percentage. Taken together, our study suggests that SPX1 may serve as a satiety signal molecular by suppressing the AgRP1 in the brain. ..
  4. Mathieu M, Trombino S, Argenton F, Larhammar D, Vallarino M. Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish. Ann N Y Acad Sci. 2005;1040:399-401 pubmed
    ..These results show that zYb and zYc receptors are expressed during ontogeny, suggesting a role for neuropeptide Y (NPY) and/or peptide YY (PYY) in organogenesis.
  5. Falcinelli S, Rodiles A, Hatef A, Picchietti S, Cossignani L, Merrifield D, et al. Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. Sci Rep. 2017;7:5512 pubmed publisher
  6. Liu Y, Tang H, Xie R, Li S, Liu X, Lin H, et al. Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish. Endocrinology. 2017;158:604-611 pubmed publisher
    ..fsh?) and luteinizing hormone beta (lh?) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, ..
  7. Ubuka T, Tsutsui K. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Gen Comp Endocrinol. 2014;209:148-61 pubmed publisher
  8. Filby A, Paull G, Bartlett E, Van Look K, Tyler C. Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav. 2010;101:576-87 pubmed publisher
    ..The wide-ranging physiological differences seen between dominant and subordinate zebrafish as a consequence of their social status suggest negative health impacts for subordinates after prolonged durations in those hierarchies. ..
  9. Dalmolin C, Almeida D, Figueiredo M, Marins L. Food intake and appetite control in a GH-transgenic zebrafish. Fish Physiol Biochem. 2015;41:1131-41 pubmed publisher
    ..peptides related to food intake: the anorexigenic proopiomelanocortin (pomc) and the orexigenic neuropeptide Y (npy)...
  10. Sundstrom G, Larsson T, Xu B, Heldin J, Larhammar D. Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b. Front Neurosci. 2013;7:29 pubmed publisher
    The neuropeptide Y (NPY) system influences numerous physiological functions including feeding behavior, endocrine regulation, and cardiovascular regulation. In jawed vertebrates it consists of 3-4 peptides and 4-7 receptors...
  11. Forner Piquer I, Maradonna F, Gioacchini G, Santangeli S, Allarà M, Piscitelli F, et al. Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. Endocrinology. 2017;158:3462-3476 pubmed publisher
    ..These findings suggest that replacement of DEHP with DiNP should be considered with caution because of observed adverse DiNP effects on aquatic organisms. ..
  12. Kundap U, Kumari Y, Othman I, Shaikh M. Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach. Front Pharmacol. 2017;8:515 pubmed publisher
    ..Therefore, combination of behavioral, neurochemical and genenetic information, makes this model a useful tool for future research and discovery of newer and safer AEDs. ..
  13. Mechaly A, Richardson E, Rinkwitz S. Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin. Gen Comp Endocrinol. 2017;246:233-240 pubmed publisher
    ..This is in line with a previously demonstrated anorexigenic function of serotonin. Our results suggest that obesity-associated ETV5 has a food intake stimulating function and that this function is modulated through serotonin. ..
  14. Mazumdar M, Sakharkar A, Singru P, Subhedar N. Reproduction phase-related variations in neuropeptide Y immunoreactivity in the olfactory system, forebrain, and pituitary of the female catfish, Clarias batrachus (Linn.). J Comp Neurol. 2007;504:450-69 pubmed
    The aim of this study was to determine whether neuropeptide Y (NPY) immunoreactivity in the cells and fibers in the forebrain and pituitary of Clarias batrachus is linked to the annual reproductive cycle...
  15. Cortés R, Teles M, Oliveira M, Fierro Castro C, Tort L, Cerdá Reverter J. Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish. Fish Physiol Biochem. 2018;44:257-272 pubmed publisher
    ..All three orexigenic peptides examined, i.e., neuropeptide y (npy), agouti-related protein (agrp), and ghrelin, increased their central expression level suggesting that these ..
  16. Falcinelli S, Rodiles A, Unniappan S, Picchietti S, Gioacchini G, Merrifield D, et al. Probiotic treatment reduces appetite and glucose level in the zebrafish model. Sci Rep. 2016;6:18061 pubmed publisher
    ..rhamnosus in the treatment of impaired glucose tolerance and food intake disorders by gut microbiota manipulation. ..
  17. Chen S, Oikonomou G, Chiu C, Niles B, Liu J, Lee D, et al. A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly. Nucleic Acids Res. 2013;41:2769-78 pubmed publisher
    ..The higher mutation rates and ability to target essentially any sequence make TALENs the superior technology for targeted mutagenesis in zebrafish, and likely other animal models. ..
  18. Davis D, Doerr H, Grzelak A, Busi S, Jasarević E, Ericsson A, et al. Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish. Sci Rep. 2016;6:33726 pubmed publisher
    ..These results underscore the influence commensal microbes have on physiological function in the host, and demonstrate bidirectional communication between the GM and the host. ..
  19. Wirbisky S, Sepúlveda M, Weber G, Jannasch A, Horzmann K, Freeman J. Embryonic Atrazine Exposure Elicits Alterations in Genes Associated with Neuroendocrine Function in Adult Male Zebrafish. Toxicol Sci. 2016;153:149-64 pubmed publisher
    ..Overall, this data indicate future studies should focus on additional neuroendocrine endpoints to determine potential functional impairments. ..
  20. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS ONE. 2012;7:e52549 pubmed publisher
    ..In conclusion, we have developed an assay that uses zebrafish, which can be applied to high-throughput screening and target gene discovery for appetite suppressants and enhancers. ..
  21. Martella A, Silvestri C, Maradonna F, Gioacchini G, Allarà M, Radaelli G, et al. Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. Endocrinology. 2016;157:1751-63 pubmed publisher
    ..We conclude that BPA is able to produce hepatosteatosis in zebrafish and human hepatocytes by up-regulating the endocannabinoid system. ..
  22. Kopp R, Billecke N, Legradi J, den Broeder M, Parekh S, Legler J. Bringing obesity to light: Rev-erbα, a central player in light-induced adipogenesis in the zebrafish?. Int J Obes (Lond). 2016;40:824-32 pubmed publisher
    ..As the pparβδ promoter includes three Rev-erbα binding sites, we hypothesize that pparβδ may be a direct target that ultimately activates Pparγ. ..
  23. Zhang Y, Li S, Liu Y, Lu D, Chen H, Huang X, et al. Structural diversity of the GnIH/GnIH receptor system in teleost: its involvement in early development and the negative control of LH release. Peptides. 2010;31:1034-43 pubmed publisher
    ..These results provided the first evidence that gnih plays an important role in the negative regulation of LH release in teleost. ..
  24. Lovett Barron M, Andalman A, Allen W, Vesuna S, Kauvar I, Burns V, et al. Ancestral Circuits for the Coordinated Modulation of Brain State. Cell. 2017;171:1411-1423.e17 pubmed publisher
    ..These experiments establish a method for unbiased discovery of cellular elements underlying behavior and reveal an evolutionarily conserved set of diverse neuromodulatory systems that collectively govern internal state. ..